I Scientists Congress of Health Technology Park of Granada (PTS)

The first Scientists Congress organized by the Health Technology Park of Granada (PTS) brings together all the research centers and aims to share the different research programs performed in the laboratories. Fundación MEDINA, the Centro de Investigación Biomédica, Genyo, the Instituto de Parasitología y Biomedicina López Neyra and the IMUDS will present the important research work developed by the different centers thar has not been broadly disseminated within the local community until now. Dr. Olga Genilloud, scientific director of MEDINA, will present the center on Thursday 14th in a plenary session focused on hosting the different institutions of the PTS. Later, she will moderate the symposium about the discovery and development of new drugs. The same day, MEDINA’s invited guest, Prof. César Nombela, will give a plenary talk on "The microbial dimension of our genomic individuality: a new perspective for therapy." All MEDINA’s researchers will also present their works in the congress and more specifically during the sessions on Oncology, Public health, Development of new drugs, Immunology and infections and Health technology as a total of 4 oral communications and 16 posters.

ORAL PRESENTATIONS

DEVELOPMENT OF NEW DRUGS

High Throughput Screening (HTS) of a collection of microbial extracts as source of new antiplasmodial natural products. Annang F, Pérez-Moreno G, El Aouad N, Pérez-Victoria I, Martín J, Crespo G, Domingo E, Cantizani J, Sánchez-Carrasco P, González I, González-Menéndez V, Tormo JR, Ruiz-Pérez LM, González-Pacanowska D, Vicente F, Genilloud O, Reyes F.

Discovery of MDN-0207, a novel glycosylated lanthipeptide with unusual cell wall mode of action. Ortiz-López FJ, Carretero-Molina D, Martín J, De la Cruz M, Sánchez M, Díaz C, González I, Morosini MI, Vicente F, Reyes F, Deisinger J, Müller A, Schneider T, Genilloud O.

HEALTH TECHNOLOGY

Fundación MEDINA natural products libraries and follow-up services for Drug Discovery and Biotechnology. Tormo JR, Vicente F, Reyes F and Genilloud O.

Preclinical Safety Analytical Platform at Fundación MEDINA. Díaz C, Pérez del Palacio J, Mena P, De la Cruz M, Cautain B, Ramos C, Reyes F, Genilloud O, Vicente F.

POSTERS

ONCOLOGY

Potential biomarkers of pancreatic ductal adenocarcinoma using an untargeted LC-HRMS-based metabolomics. Martín A, Franco D, Díaz C, Jiménez C, Prados J, Melguizo C, Genilloud O, Vicente F, Caba O, González E, González B, Martínez Galán J, Pérez del Palacio J.

PUBLIC HEALTH

Drug discovery in tropical diseases: Microbial extracts collections as a ready source of new potent antiparasitic natural compounds. Annang F, Pérez-Moreno G, Pérez-Victoria I, Martín J, Bosch-Navarrete C, Ruiz-Pérez L, Genilloud O, Reyes F, Vicente F, González-Pacanowska D.

DEVELPMENT OF NEW DRUGS

New analogues of nosokomycin and polycyclic xanthones with antibacterial properties from MEDINA´s actinomycetes collection. Carretero-Molina D, Ortiz-López FJ, Díaz C, De la Cruz M, González I, Reyes F, Vicente F, Genilloud O.

Fundación MEDINA an official partner site of EU-OPENSCREEN. Vicente F, Reyes F, Genilloud O.

Multicelular tumor spheroids (MCTS) – A powerful tool in drug discovery screening process. Franciskovic M, Ramos C, Genilloud O and Vicente F.

Antimicrobial activities of actinomycetes isolated from Sonchus crassifolius and Limonium collected from south-eastern Spain (Granada). González I, Ruiz S, Estévez MM, Sánchez I, Melguizo MA, Sánchez P, De la Cruz M, Díaz C, Tormo J, Genilloud O.

Scale up fermentation of Streptomyces hygroscopicus in submerged bioreactor - a potential source of bioactive compounds with skin-whitening activity. Georgousaki K, Tsafantakis N, Oves-Costales D, González I, Genilloud O, Cautain B, Lambert C, Fokialakis N.

Krisynomycin and Krisynomycins B and C as Imipenem Potentiators Against Methicillin-resistant Staphylococcus aureus (MRSA) Produced by Streptomyces sp. Pérez-Bonilla M, González I, de la Cruz M, Martín J, Vicente F, Genilloud O, Reyes F.

High Content Bioimaging platform at MEDINA. Ramos C, Cautain B, Genilloud O and Vicente F.

Development of an assay for searching new antibiotics from microbial natural products against Neisseria gonorrhoeae. Sánchez P, Melguizo A, Romero C, Martín J, Genilloud O, Vicente F, de la Cruz M.

Genome mining of the lichen-isolated strain Amycolatopsis pretoriensis CA-128772. Sánchez-Hidalgo M, Díaz-Muñoz C, González I, Tormo JR, Martín J, Genilloud O.

Natural Products as new sources of nuclear translocation inhibitors using High Content Bio-Imaging. Mackenzie TA, Cautain B, González Menéndez V, Link W, Vicente F, Genilloud O.

Fungal grass endophytes as biocontrol agents against fungal phytopathogens. Gonzalez-Menéndez V, Serrano Bacallao R, Martin J, Tormo JR and Genilloud O.

Fundación MEDINA’s natural products collection for anti-tuberculosis drug Discovery. de la Cruz M, Lacret R, Oves D, Sánchez P, Melguizo A, Rodríguez L, Tormo JR, Moreno C, Muñoz F, Vicente F, Genilloud O, Reyes F.

IMMUNOLOGY AND INFECTIOUS DISEASES

Gut Microbiota Profiling: A Metabolomics-Metagenomics Based Approach to Identify and Isolate Compounds Affecting Human Health. Pérez del Palacio J, Díaz C, De la Cruz M, Martín A, Gonzalez I, Sánchez M, Vicente F, Reyes F, Genilloud O.

HEALTH TECHNOLOGY

Identification and in silico analysis of a BGC encoding the biosynthesis of three new 36-membered bioactive macrolactones. Oves-Costales D, Sánchez-Hidalgo M, Pérez-Victoria I, Lacret R, Reyes F, Genilloud O.