Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior, Neuropharmacology

MEDINA has participated in the paper about ki16425 modulation of the effects of ethanol on the brain and behavior, published in Neuropharmacology. This is a broad and complete paper at the technical and experimental level, including numerous data and procedures, part of the research line on LPA and alcoholism led by Drs. Fernando Rodríguez de Fonseca and Estela Castilla-Ortega at the IBIMA (Instituto de Investigación Biomédica de Málaga). The results of this study suggest that antagonists of the receptor LPA1/3 could represent a new family of drugs for the treatment and prevention of disorders produced by the excessive consumption of alcoholic drinks. MEDINA has participated in this work through its bioanalysis platform, estimating the ki164525 antagonist quantities present in the brain and plasma of the murine models employed in the study.

Dr Jose Pérez del Palacio and Caridad Diaz lead the bioanalisis platform at MEDINA, actively involved in this and other numerous projects for the quantification of durg candidates and other biologically relevant molecules present in biological matrices.