Martínez-Arribas B, Díaz-González R, Weaver J, Walden M, Mackenzie C, Dounay AB, Ramos MC, Genilloud O, Ruiz-Pérez LM, Mottinelli M, Ferrins L, González-Pacanowska D. Identification of 1,2-dihydroquinazolin-2-ones kinase inhibitors as anti-coronavirus agents. Antiviral Res. 2026 Sep 15:106534. doi: 10.1016/j.antiviral.2026.106534 Abstract
Guerra-Mateo D, González-Menéndez V, Gené J, Crous PW, Bensch K, Genilloud O, Cano-Lira JF. Novel insights into the phylogenetic and metabolic diversity of preussia-like fungi. Stud Mycol. 2026 May 20;114:437-486. doi: 10.3114/sim.2026.114.03 Abstract
Melong R, Tchamgoue J, Tsamo AT, Dzoyem JP, Annang FB, Gelbcke M, Meyer F, Wabo Fotso Kapche GD, Reyes F, Kouam SF. Mass spectrometry-guided isolation of paecilamide, A new hybrid alkylated pyridine amide alkaloid from Paecilomyces dactylethromorphus CECA 108. Phytochem. Lett. Volume 76,2026, 104253, ISSN 1874-3900 doi: 10.1016/j.phytol.2026.104253 Abstract
Rubini D, Parra-López M, Holzerland J, Rodríguez-Martínez A, Martina MG, Valenti ME, Ramos MC, Castillo F, Harty RN, Lanko K, Bauer L, Pérez-Sanchez H, Diederich S, Luque I, Radi M. Discovery of a novel class of broad-spectrum antivirals targeting the UEV domain of TSG101 in the host ESCRT pathway. Eur J Med Chem. 2026 Jul 17;318:119162. doi: 10.1016/j.ejmech.2026.119162 Abstract
Pecin G, Gonzalez-Menendez V, Martin J, Annang F, Mackenzie TA, Reyes F, Genilloud O. Discovery of spectabilide A, a new cytotoxic cyclic lipodepsipeptide from Trichothecium spectabile comb. nov. (Ascomycota, Sordariomycetes) revealed by OSMAC-guided metabolomics. IMA Fungus 17: e192814. https://doi.org/10.3897/imafungus.17.192814 Abstract
Baek KH, Lee H, Byun S, Genilloud O, Ioset JR, Shum D, No JH. In vitro profiling of Trypanosoma cruzi inhibitors identified from High throughput Screening and application to parasite painting. Int J Parasitol Drugs Drug Resist. 2026 May 14:31:100651. doi: 10.1016/j.ijpddr.2026.100651 Abstract
Desai R, Preet G, Astakala RV, Romero-Otero A, Sanchez P, Mackenzie TA, Larsen TO, Ebel R, Jaspars M. An Exploratory LC-HRMS Metabolomics Study of Culture Medium-Dependent Metabolic Variation and Bioactivity in Ten Fungal StrainsInt. J Mol Sci. 2026 Apr 27;27(9):3866. doi: 10.3390/ijms27093866 Abstract
Karyofyllidou G, Serrano R, González-Menéndez V, Martín J, Mackenzie TA, Ramos MC, Ortega-Vidal J, Thomas OP, Tormo JR, Genilloud O, Reyes F. Sulphopreussomerins: Sulfur-Containing Preussomerins Isolated from the Marine-Derived Fungus Pyrenochaetopsis indica. J Nat Prod. 2026 May 15. doi: 10.1021/acs.jnatprod.6c00324 Abstract
Larnder AH, Murphy RA, Srour B, Déchamp N, Galan P, Hercberg S, Bourhis L, Díaz C, Genilloud O, Touvier M, Deschasaux-Tanguy M. Plasma metabolites, dietary intakes, and breast cancer incidence: a prospective case-cohort study in NutriNet-Santé. Am J Clin Nutr. 2026 May 9:101342. doi: 10.1016/j.ajcnut.2026.101342 Abstract
Becerril A, Pérez-Victoria I, Martín J, Salas JA, Reyes F, Méndez C. Parallel Pathways and Alternative Macrocyclizations in the Biosynthesis of Largimycins by Cytochrome P450 Minus Mutants of Streptomyces argillaceus. J Nat Prod. 2026 May 7. doi: 10.1021/acs.jnatprod.6c00240 Abstract
Tocino-Márquez I, Zehl M, Batajic J, Séneca J, Pjevac P, Murillo-Alba J, Martín J, Sekurova ON, Zotchev SB. Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments. Front Microbiol. 2026 Apr 20;17:1793713. doi: 10.3389/fmicb.2026.1793713 Abstract
Bernabeu-Sanchis A, Mackenzie TA, Ramos MC, García A, Villarroel-Vicente C, Vila L, Tormo JR, Cortes D, Cabedo N. Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines. ChemMedChem. 2026 Jan; 21(2):e202500904. Abstract
Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Martín J, Tormo JR, Cho A, Byun SY, Shum D, Ioset JR, Reyes F, Genilloud O. Kronopolitides A-F, a Family of 36-Membered Polyol Macrolides with Antiparasitic Activity against Chagas Disease. J Nat Prod. 2026 Jan 23;89(1):170-188. Abstract
Duncan H, Domingo-Contreras E, Athanasiou S, Fernandez-Godino R, Castillo F, Camacho A. Affinity-based selection of anti-Feline Leukaemia Virus p27 monoclonal antibodies for efficient lateral flow assay development. Anal Biochem. 2026 Feb;709:116013. Abstract
Rodríguez-Pérez C, Vázquez-Aguilar A, Rangel Huerta OD, Sánchez-Rodríguez E, Gil Á, Díaz C, Vargas F, Mesa MD. New insights into the plasma and urinary metabolomic signatures of spontaneously hypertensive rats. PLoS One. 2026 Apr 3;21(4):e0344682. doi: 10.1371/journal.pone.0344682 Abstract
Machushynets NV, Elsayed SS, Du C, Lysenko V, de la Cruz M, Sanchez P, Genilloud O, Martin NI, Liles MR, van Wezel GP. Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated Paenibacillus species. mSystems. 2026 Mar 24;11(3):e0149625. doi: 10.1128/msystems.01496-25 Abstract
Jennings L K, Kaur N, Ramos MC, de la Cruz M, Reddy MM, Reyes F, Thomas OP. Ascidiolides, nitrogenous phthalides from the solitary ascidian Ascidia virginea from the Northeastern Atlantic, and structural revision of the closely related ascidines. Organic & Biomolecular Chemistry. 1477-0520. Abstract
Castillo F, Mackenzie TS, Domingo E, Iañez I, Robers MB, Wilkinson J, Kay-Tsumagari E, O’Brien M, Genilloud O, Fernandez-Godino R, Ramos MC. Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays. SLAS Discovery. Volume 35, 2025, Abstract
Fernández-Pastor I, González-Menéndez V, González I, Sanchez P, Serrano R, Mackenzie TA, Oves-Costales D, Casares Porcel M,Genilloud O, Reyes F. Glycinocins E–H, Antimicrobial Lipopeptides Produced by a Streptomyces Strain. Journal of Natural Products. 2025/08/22. Abstract
Serrano R, González-Menéndez V, Pérez-Victoria I, Sánchez I, Toro C, Mackenzie TA, Martín J, Tormo JR, Genilloud O. Leaf litter associated fungi from South Africa to control fungal plant pathogens. Scientific Reports, 15, 30219 (2025). Abstract
Azpiazu-Muniozguren M, Valgañón-Pérez E, García-Martínez M, Rodriguez-Paniagua A, Clark H P, Justicia C, Martín J, de la Cruz M, Reyes F, Laorden L, Martinez-Malaxetxebarria I, Martinez-Ballesteros I. Isolation of Halophilic and Halotolerant Bacterial Strains, Screening for Bioactive Compounds and Characterisation of Metabolites Produced by Pseudoalteromonas sp. ASV78. Environmental Microbiology Reports, 17, no. 4: e70159. Abstract
Annang FB, Pérez-Moreno G, Bosch-Navarrete C, González-Menéndez V, Martín J, Pérez-Bonilla M, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. Bovistols E and F, New bis-Sesquiterpenes Isolated From Psathyrella microrhiza CF-117891. Chemistry & Biodiversity. e00538. Abstract
Ortiz-López FJ, Oves-Costales D, Murillo-Alba J, Martín J, Díaz C, de la Cruz M, Jørgensen TS, Reyes F, Weber T, Genilloud O. Dracomicins, Hybrid Oligosaccharide–Nonribosomal Peptide Antibiotics from Amycolatopsis Species. Organic Letters, 2025, ASAP (June 3). Abstract
Ruiz-Jiménez AL, Heredia G, Peraza-Jiménez K, Felicia A, Vicente F,de la Cruz M, de Pedro N, Martín J, Reyes F, Gamboa-Angulo M. Beltraniella portoricensis strain MRH42, a saprophytic fungus from Mexico, produces antimicrobial and cytotoxic hymenopsins. Letters in Applied Microbiology. Volume 78, Issue 3, March 2025, ovaf023. Abstract
Vitorino IR, Santos JDN, Crespo G, Pérez-Victoria I, Martín J, Rodriguez L, Ramos MC, Martins TP, Leão PN, Vicente F, Vasconcelos V, Lage OM, Reyes F. Alichondrichlorin, a Novel Chlorohydrin-Containing Natural Product With Tumoral Cytotoxic Activity Isolated From the Planctomycetota Bacterium Alienimonas chondri LzC2T. Microbial Biotechnology. Volume18, Issue2, February 2025. e70076 Abstract
Tenorio CM, Nerea M. Molina, Castilla JA, Rodríguez-Guirado S, Méndez R, Fernández-Godino R, Altmäe S, Díaz C. Refining the seminal biomarker detection: metabolome profiles before and after the liquefaction procedure. Reproductive BioMedicine Online, 2025, 104856, Abstract
Wolff C, Neuenschwander M, Beese CJ,Sitani D, Ramos MC, Srovnalova A, Varela MJ, Polishchuk P, Skopelitou KE, Skuta C, Stechmann B, Brea J, ClausenMH, Dzubak P, Fernández-Godino R, Genilloud O, Hajduch M, Loza MI, Lehmann M , von Kries JP, Sun H, Schmied C. Morphological profiling data resource enables prediction of chemical compound properties. Iscience Open Access, Volume 28, Issue 5112445May 16, 2025. Abstract
Rodríguez-Martínez A, Giraldo-Ruiz L, Ramos MC, Luque I, Ribeiro D, Postigo-Corrales F, Alburquerque-González B, Montoro-García S, Arroyo-Rodríguez AB, Conesa-Zamora P, Hurtado AM, Luengo-Gil G, Pérez-Sánchez H. Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer. Scientific Reports, 15, 14906 (2025). Abstract
Carretero-Ledesma M, Li J, Martín-Escolano J, Herrera-Espejo S, Xu J, Chen H, Díaz-Navarro C, Pachón J, Sánchez-Céspedes J, Zhou J, Pachón-Ibáñez ME. Salicylamide derivative JMX0312 protects immunosuppressed Syrian hamsters against adenovirus lethal challenge. Antiviral Research,Volume 238,2025, 106155. Abstract
Gadiya Y, Genilloud O, Bilitewski U, Brönstrup M, von Berlin L, Attwood M, Gribbon P, Zaliani A. Predicting Antimicrobial Class Specificity of Small Molecules Using Machine Learning. Journal of Chemical Information and Modeling. 2025 Mar 10;65(5):2416-2431. Abstract
Armento A, Sonntag I, Almansa-Garcia AC, Sen M, Bolz S, Arango-Gonzalez B, Kilger E, Sharma R, Bharti K, Fernandez-Godino R, de la Cerda B, Clark SJ, Ueffing M. The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells. Frontiers in Immunology. 16:1527018. doi: Abstract
Camacho J, Armstrong MS, García-Martínez L, Díaz C, Gómez-Llorente C. Single-cell spatial (scs) omics: Recent developments in data analysis. TrAC Trends in Analytical Chemistry, Volume 183, 2025, 118109. Abstract
Aguirrebengoa M, Moreno B, GuiradoN. Microbe-mediated organic fertilization increases insect predator attraction upon fruit damage in olive trees. Soil Ecology Letters. 7, 240281 (2025). Abstract
Pérez-Victoria I, El Aouad N, González-Menéndez V, de La Cruz, M, Fernández L, Martín J, Tormo JR, Genta-Jouve G, Thomas OP,Vicente F, Bills GF, Genilloud O, Reyes F. MDN-0057 to MDN-0060, a Family of Broad-Spectrum Antibiotics against Gram-Negative Pathogens Produced by Ophiosphaerella korrae. Journal of Natural Products, 2025. Abstract
Bagán A, López-Ruiz A, Abás S, Ruiz-Cantero MC, Vasilopoulou F, Taboada-Jara T, Griñán-Ferré C, Pallàs M, Muguruza C, Diez-Alarcia R, Callado LF, Entrena JM, Cobos EJ, Pérez B, Morales-García JA, Molins E, De Jonghe S, Daelemans D, Brea J, Val C, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Díaz C, Fernández-Godino R, Genilloud O, Beljkaš M, Oljačić S, Nikolic K, Escolano C. Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2 H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties. Journal of Medicinal Chemistry. 2025 Feb 13;68(3):2551-2573. Abstract
Georgousaki K, Tsafantakis N, González I, Martin J, Mackenzie TA, Gumeni S, Trougakos IP, Reyes F, Genilloud O, Fokialakis N. Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete Actinomycetospora sp. CA-287887. Separations. 2025, 12, 57. Abstract
Montero F, Parra-López M, Rodríguez-Martínez A, Murciano-Calles J, Buzon P, Han Z, Lin LY, Ramos MC, Ruiz-Sanz J, Martinez JC, Radi M, Moog C, Diederich S, Harty RN, Pérez-Sánchez H, Vicente F, Castillo F, Luque I. Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals. Protein Science. 2025 Jan;34(1):e70005. Abstract
Vicente F, Reyes F, Genilloud O. Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides. Natural Product Reports, 2024, Advance Article. org/10.1039/D4NP00044G Abstract
Prado-Alonso L, Ye S, Pérez-Victoria I, Montero I, Riesco P, Ortiz-López FJ, Martín J, Olano C, Reyes F, Méndez C. Genome Mining for Diazo-Synthesis-Related Genes in Streptomyces sp. CS057 Unveiled the Cryptic Biosynthetic Gene Cluster crx for the Novel 3,4-AHBA-Derived Compound Crexazone 2. Biomolecules. 2024; 14(9):1084. https://doi.org/10.3390/biom14091084 Abstract
Ortiz-López FJ, Oves-Costales D, Guerrero Garzón JF, Gren T, Baggesgaard Sterndorff E, Jiang X, Sparholt Jo̷rgensen T, Blin K, Fernández-Pastor I, Tormo JR, Martín J, Sánchez P, de la Cruz Moreno M, Reyes F, Genilloud O, Weber T. Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species Journal of Natural Products, 2024, 87, 2515-2522. DOI: 10.1021/acs.jnatprod.4c00633 Abstract
Jover I, Ramos M., Escámez MJ, Lozoya E, Tormo JR, de Prado-Verdún D, Mencía A, Pont M, Puig C, Larraufie MH, Gutiérrez-Caballero C, Reyes F, Trincado JL, García-González V, Cerrato R, Andrés M, Crespo M, Vicente F, Godessart N, Genilloud O, Larcher F, Nueda A. Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa. Scientific Reports 14, 18969 (2024). https://doi.org/10.1038/s41598-024-67398-8 Abstract
Pérez-Victoria I. Natural Products Dereplication: Databases and Analytical Methods. Progress in the Chemistry of Organic Natural Products, vol 124. Springer Nature, Cham. https://doi.org/10.1007/978-3-031-59567-7_1 Abstract
Fernández-Pastor I, González-Menéndez V, González I, Serrano R, Mackenzie TA, Benítez G, Casares-Porcel M, Genilloud O, Reyes F. Escuzarmycins A–D, Potent Biofungicides to Control Septoria tritici Blotch. Journal of Agricultural and Food Chemistry 2024 72 (27), 15256-15264. DOI: 10.1021/acs.jafc.4c01303 Abstract
Palma-Morales M, Daniel Rangel-Huerta O, Díaz C, Castilla-Ortega E, Rodríguez-Pérez C. Integration of network-based approaches for assessing variations in metabolic profiles of alkalized and non-alkalized commercial cocoa powders. Food Chemistry: X, 2024, 101651, ISSN 2590-1575, https://doi.org/10.1016/j.fochx.2024.101651 Abstract
Ramos MC, Crespo-Sueiro G, de Pedro N, Griñán-Lisón C, Díaz C, Pérez-Victoria I, González-Menéndez V, Castillo F, Pérez del Palacio J, Tormo JR, Choquesillo-Lazarte D, Marchal JA, Vicente F, Fernández-Godino R, Genilloud O, Reyes F. Onychocolone A produced by the fungus Onychocola targets cancer stem cells and stops pancreatic cancer progression by inhibiting MEK2-dependent cell signaling. Biomedicine & Pharmacotherapy, Volume 177, 2024, 117018, https://doi.org/10.1016/j.biopha.2024.117018. Abstract
Girao M, Murillo-Alba J, Martín J, Pérez-Victoria I, Leite RB, Urbatzka R, Leao PN, Carvalho MF, Reyes F. Cellulamides: a new Family of Marine-sourced Linear Peptides from the Underexplored Cellulosimicrobium Genus. Marine Drugs. 2024, 22, 268. https://doi.org/10.3390/md22060268 Abstract
Castillo F, Ramírez D, Ramos MC, Martinez-Arribas B, Domingo-Contreras E, Mackenzie TA, Peña-Varas C, Lindemann S, Montero F, Annang F, Vicente F, Genilloud O, González-Pacanowska D, Fernandez-Godino R. Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broadspectrum antivirals. Frontiers in Pharmacology. 15:1390705. doi: 10.3389/fphar.2024.1390705 Abstract
Mackenzie TA, Tormo JR, Cautain B, Martínez G, Sánchez I, Genilloud O, Vicente F, Ramos MC. Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products. SLAS Technology. 2024 Jun;29(3):100111. doi: 10.1016/j.slast.2023.10.003. Abstract
Olmedo CG, Beltrán LD, García VM, Ferrer JLP, Jiménez AC, Cubero RU, del Palacio JP, Díaz C, Vicente F, Rovira PS. Assessment of Untargeted Metabolomics by Hydrophilic Interaction Liquid Chromatography−Mass Spectrometry to Define Breast Cancer Liquid Biopsy-Based Biomarkers in Plasma Samples. International Journal of Molecular Sciences. 2024; 25(10):5098. https://doi.org/10.3390/ijms25105098 Abstract
Álvarez-León F, Rosado-Aguilar JA, Gamboa-Angulo M, Flota-Burgos GJ, Martin J, Reyes F. Anthelmintic activity and chemical profile of native plant extracts from the Yucatan Peninsula against Toxocara canis. Acta Tropica. 2024 Jul;255:107214. doi: 10.1016/j.actatropica.2024.107214 Abstract
Virués-Segovia JR, Pinedo C, Zorrilla D, Sánchez-Márquez J, Sánchez P, Ramos MC, de la Cruz M, Aleu J and Durán-Patrón R. Discovery of new eremophilanes from the marine-derived fungus Emericellopsis maritima BC17 by culture conditions changes: evaluation of cytotoxic and antimicrobial activities. Frontiers in Marine Science. 11:1386175. doi: 10.3389/fmars.2024.1386175 Abstract
Jennings LK, Kaur N, Ramos MC, Reyes F, Reddy MM, Thomas OP. Highly Concentrated Linear Guanidine Amides from the Marine Sipunculid Phascolosoma granulatum. Journal of Natural Products. 2024. DOI: 10.1021/acs.jnatprod.3c01186 Abstract
Esquivel-Chi MC, Ruiz-Sánchez E, Ballina-Gómez H, Martín J, Reyes F, Carnevali G, Tapia-Muñoz JL, Gamboa-Angulo M. Repellent screening of ethanol extracts from plants of the Yucatan Peninsula against Bemisia tabaci (Gennadius, 1889) and chemical profile of Malpighia glabra L. leaves. Journal of Plant Diseases and Protection 131, 811–821 (2024). https://doi.org/10.1007/s41348-024-00901-5 Abstract
Domingo-Contreras E, Tormo JR, González V, Mackenzie TA, Martín-Serrano J, Magiera-Mularz K, Kitel R, Reyes F, Genilloud O, Fernández R, Ramos MC, Castillo F. Discovery of bioactive natural products of microbial origin as inhibitors of the PD-1/PD-L1 protein-protein interaction. International Journal of Biological Macromolecules, Volume 264, Part 1, 2024, 130458. https://doi.org/10.1016/j.ijbiomac.2024.130458. Abstract
García-Gutiérrez C, Pérez-Victoria I, Montero I, Fernández-De la Hoz J, Malmierca MG, Martín J, Salas JA, Olano C, Reyes F, Méndez C. Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller Streptomyces CS113. International Journal of Molecular Sciences. 2024; 25(4):2347. https://doi.org/10.3390/ijms25042347 Abstract
Fernández-Pastor I, Ortiz-López FJ, Oves-Costales D, Martín J, Sánchez P, Melguizo Á, Reyes F, Weber T, Genilloud O. Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca2+-Binding Motif. Organic Letters. 2024 Feb 23;26(7):1343-1347. doi: 10.1021/acs.orglett.3c04195. Abstract
Vitorino IR, Pinto E, Martín J, Mackenzie TA, Ramos MC, Sánchez P, de la Cruz M, Vicente F, Vasconcelos V, Reyes F, Lage OM. Uncovering the biotechnological capacity of marine and brackish water Planctomycetota. Antonie Van Leeuwenhoek. 2024 Jan 23;117(1):26. doi: 10.1007/s10482-023-01923-z. Abstract
Mackenzie TA, Reyes F, Martínez M, González-Menéndez V, Sánchez I, Genilloud O, Tormo JR, Ramos MC. Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells. 2024; 29(2):425. https://doi.org/10.3390/molecules29020425 Abstract
Cabello-Donayre M, Cabello-Donayre I, Guerra D, Orrego LM, Morales JC, Cautain B, Vicente F, Pérez-Victoria JM. A yeast-based high-throughput screen identifies inhibitors of trypanosomatid HRG heme transporters with potent leishmanicidal and trypanocidal activity. International Journal of Antimicrobial Agents. 2024 Mar;63(3):107092. doi: 10.1016/j.ijantimicag.2024.107092. Abstract
González-Olmedo C, García-Verdejo FJ, Reguera-Teba A, Rosa-Garrido C, López-López JA, Díaz-Beltrán L, García PM, Luque-Caro N, Gálvez-Montosa F, Ortega-Granados AL, Ruiz-Sanjuan M, Cózar-Ibáñez A, Sainz J, Marchal JA, Camacho J, Del Palacio JP, Fernández-Godino R, Díaz C, Sánchez-Rovira P. Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis. Clinical and Translational Medicine. 2024 Jan;14(1):e1541. doi: 10.1002/ctm2.1541. Abstract
Dos Santos JDN, Pinto E, Martín J, Vicente F, Reyes F, Lage OM. Unveiling the bioactive potential of Actinomycetota from the Tagus River estuary. International Microbiology. 2024 Jan 18. doi: 10.1007/s10123-024-00483-0. Abstract
Kouam AF, Mabou FD, Fu L, Koagne RR, LI Y, Owona Ba, Zeuko’o EM, FEPA AGK, Galani BRT, Reyes F, Njayou FN, Moundipa PF, Gao GF. Insights into the inhibition mechanisms of MERS-CoV and SARS-CoV2 papain-like proteases by inhibitors from Crinum distichum: In vitro and in silico analysis. South African Journal of Botany. 2024, 165, 290-306. https://doi.org/10.1016/j.sajb.2024.01.004 Abstract
Peña-Martín J, García-Ortega MB, Palacios-Ferrer JL, Díaz C, Ángel García M, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias Santiago S, Vicente F, Del Val C, Pérez Del Palacio J, Marchal JA. Identification of novel biomarkers for early diagnosis of malignant melanoma by untargeted LC-HRMS-based metabolomics: a pilot study. British Journal of Dermatology. 2024 Jan 12:ljae013. doi: 1093/bjd/ljae013. Abstract
Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Oves-Costales D, Martín J, Murillo-Alba J, Tormo JR, Cho A, Byun SY, No JH, Shum D, Ioset JR, Genilloud O, Reyes F. Madurastatins with Imidazolidinone Rings: Natural Products or Side-Reaction Products from Extraction Solvents? International Journal of Molecular Sciences. 2024, 25(1):301. doi: 10.3390/ijms25010301. Abstract
Santos JDND, Klimek D, Calusinska M, Lobo-da-Cunha A, Catita J, Gonçalves H, González I, Lage OM. Microbacterium memoriense nov., a member of the Actinomycetota from marine beach sediment of the north coast of Portugal. International Journal of Systematic and Evolutionary Microbiology. 2024 Jan;74(1). doi: 10.1099/ijsem.0.006230. Abstract
Matias-Valiente L, Sanchez-Fernandez C, Rodriguez-Outeiriño L, Ramos MC, Díaz C, Crespo G, González-Menéndez V, Genilloud O, Reyes F, Montolio M, Hernandez-Torres F, Aranega AE. Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy. Biomedicine & Pharmacotherapy. Volume 170, January 2024, 116056. doi: 10.1016/j.biopha.2023.116056. Abstract
Resa S, González M, Reyes F, Pérez-Victoria I. Revision of the full stereochemistry of telomycin. Organic Chemistry Frontiers, 2024, 11, 306-314. https://doi.org/10.1039/D3QO01411H Abstract
Martínez-Arribas B, Annang F, Díaz-González R, Pérez-Moreno G, Martín J, Mackenzie TA, Castillo F, Reyes F, Genilloud O, Ruiz-Pérez LM, Vicente F, Ramos MC, González-Pacanowska D. Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity. Microbiology Spectrum. 2024 Jan 11;12(1):e0167923. doi: 10.1128/spectrum.01679-23. Abstract
O’Brien S, Lacret R, Reddy MM, Jennings LK, Sánchez P, Reyes F, Mungkaje A, Calabro K, Thomas OP. Additional Sarasinosides from the Marine Sponge Melophlus sarasinorum Collected from the Bismarck Sea. Journal of Natural Products, 2023, https://doi.org/10.1021/acs.jnatprod.3c01045 Abstract
Martínez-Arribas B, Annang F, Díaz-González R, Pérez-Moreno G, Martín J, Mackenzie TA, Castillo F, Reyes F, Genilloud O, Ruiz-Pérez LM, Vicente F, Ramos MC, González-Pacanowska D. Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity. Microbiology Spectrum. DOI: https://doi.org/10.1128/spectrum.01679-23 Abstract
Resa S, González M, Reyes F, Pérez-Victoria I. Revision of the full stereochemistry of telomycin. Organic Chemistry Frontiers, 2023, https://doi.org/10.1039/D3QO01411H Abstract
Matilla MA, Evans TJ, Martín J, Udaondo Z, Lomas-Martínez C, Rico-Jiménez M, Reyes F, Salmond GPC. Herbicolin A production and its modulation by quorum sensing in a Pantoea agglomerans rhizobacterium bioactive against a broad spectrum of plant-pathogenic fungi. Microbial Biotechnology. 2023; 16:c 1690-1700. https://ami-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.14193 Abstract
Santamaría RI, Martínez-Carrasco A, Tormo JR, Martín J, Genilloud O, Reyes F, Díaz M. Interactions of Different Streptomyces Species and Myxococcus xanthus Affect Myxococcus Development and Induce the Production of DK-Xanthenes. International Journal of Molecular Sciences. 2023; 24(21):15659. https://doi.org/10.3390/ijms242115659 Abstract
Thomas A. Mackenzie, José R. Tormo, Bastien Cautain, Germán Martínez, Isabel Sánchez, Olga Genilloud, Francisca Vicente, Maria C. Ramos. Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products. SLAS Technology, 2023, ISSN 2472-6303, https://doi.org/10.1016/j.slast.2023.10.003 Abstract
Fernández-Pastor I, González-Menéndez V, Martínez Andrade K, Serrano R, Mackenzie TA, Benítez G, Casares-Porcel M, Genilloud O, Reyes F. Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides. Journal of Fungi. 2023; 9(9):887. https://doi.org/10.3390/jof9090887 Abstract
Bagán A, Rodriguez-Arévalo S, Taboada-Jara T, Griñán-Ferré C, Pallàs M, Brocos-Mosquera I, Callado LF, Morales-García JA, Pérez B, Diaz C. Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease. Pharmaceutics. 2023; 15(10):2381. https://doi.org/10.3390/pharmaceutics15102381 Abstract
Serrano R, González-Menéndez V, Tormo JR, Genilloud O. Development and Validation of a HTS Platform for the Discovery of New Antifungal Agents against Four Relevant Fungal Phytopathogens. Journal of Fungi. 2023; 9(9):883. https://doi.org/10.3390/jof9090883 Abstract
Kokkini M, Oves-Costales D, Sánchez P, Melguizo Á, Mackenzie TA, Pérez-Bonilla M, Martín J, Giusti A, de Witte P, Vicente F, Genilloud O, Reyes F. New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains. Marine Drugs. 2023 Aug 7;21(8):443. doi:10.3390/md21080443. Abstract
Huang W, Rodrigues J, Bilgo E, Tormo JR, Challenger JD, De Cozar-Gallardo C, Pérez-Victoria I, Reyes F, Castañeda-Casado P, Gnambani EJ, Hien DFS, Konkobo M, Urones B, Coppens I, Mendoza-Losana A, Ballell L, Diabate A, Churcher TS, Jacobs-Lorena M. Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes. Science. 2023 Aug 4;381(6657):533-540. doi: 10.1126/science.adf8141. Abstract
Rodríguez-Ruiz M, Ramos MC, Campos MJ, Díaz-Sánchez I, Cautain B, Mackenzie TA, Vicente F, Corpas FJ, Palma JM. Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles. Antioxidants. 2023; 12(7):1461. https://doi.org/10.3390/antiox12071461 Abstract
Palma JM, Pérez del Palacio J, Rodríguez-Ruiz M, González-Gordo S, Caridad Díaz C, Ramos MC, Cautain B, Vicente F, Corpas FJ (2023). Nitric Oxide in Health and Disease. Therapeutic Applications in Cancer and Inflammatory Disorders (Morbidelli L, Bonavida B, Muntané J, eds.) pp. 193-210, Chapter 8 – Pepper fruit, as a nutraceutical food, shows antiproliferative activity against tumor cells and it is potentiatied by nitric oxide (NO). Academic Press-Elsevier. https://doi.org/10.1016/B978-0-443-13342-8.00012-0 Abstract
Ye S, Molloy B, Pérez-Victoria I, Montero I, Braña AF, Olano C, Arca S, Martín J, Reyes F, Salas JA, Méndez C. Uncovering the Cryptic Gene Cluster ahb for 3-amino-4-hydroxybenzoate Derived Ahbamycins, by Searching SARP Regulator Encoding Genes in the Streptomyces argillaceus Genome. International Journal of Molecular Sciences. 2023 May 3;24(9):8197. doi: 10.3390/ijms24098197. Abstract
Gaudêncio SP, Bayram E, Lukić Bilela L, Cueto M, Díaz-Marrero AR, Haznedaroglu BZ, Jimenez C, Mandalakis M, Pereira F, Reyes F, Tasdemir D. Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation. Marine Drugs. 2023 May 19;21(5):308. doi: 10.3390/md21050308. Abstract
Ortiz-López F J, Oves-Costales D, Carretero-Molina D, Martín J, Díaz C, de la Cruz M, Román-Hurtado F, Álvarez-Arévalo M, Jørgensen T, Reyes F, Weber T, Genilloud O. Crossiellidines A–F, Unprecedented Pyrazine-Alkylguanidine Metabolites with Broad-Spectrum Antibacterial Activity from Crossiella sp. Organic Letters. 2023, May 10. https://doi.org/10.1021/acs.orglett.3c01088 Abstract
Molina-Tijeras JA, Ruiz-Malagón AJ, Hidalgo-García L, Diez-Echave P, Rodríguez-Sojo MJ, Cádiz-Gurrea MdlL, Segura-Carretero A, del Palacio JP, González-Tejero MR, Rodríguez-Cabezas ME, Gálvez J, Rodríguez-Nogales A, Vezza T, Algieri F. The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice. Antioxidants. 2023; 12(4):832. https://doi.org/10.3390/antiox12040832 Abstract
Deisinger JP, Arts M, Kotsogianni I, Puls JS, Grein F, Ortiz-López FJ, Martin NI , Müller A, Genilloud O, Schneider T. Dual targeting of the class V lanthipeptide antibiotic cacaoidin. iScience. 2023 Mar 11;26(4):106394. doi: 10.1016/j.isci.2023.106394. Abstract
Durcik M, Cotman A E, Toplak Z, Možina S, Skok Ž, Szili P E, Czikkely M, Maharramov E, Vu TH, Piras M V, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo L A, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol S V, Jin Z, Vicente F, Ramos M C, Mundy J E A, Maxwell A, Stevenson C A M, D M Lawson, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen G V, Sterk G J, Kikelj D, Pal C, Tomašič T, Mašič L P. New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus. Journal of Medicinal Chemistry. 2023 66 (6), 3968-3994 DOI: 10.1021/acs.jmedchem.2c01905 Abstract
Acebedo-Martínez FJ, Alarcón-Payer C, Verdugo-Escamilla C, Martín J, Frontera A, Domínguez-Martín A, Gómez-Morales J, Choquesillo-Lazarte D. Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals. Pharmaceuticals. 2023; 16(3):370. https://doi.org/10.3390/ph16030370 Abstract
Annang FB, Pérez-Moreno G, Bosch-Navarrete C, González-Menéndez V, Martín J, Mackenzie TA, Ramos MC, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171. Pharmaceutics. 2023; 15(2):492. https://doi.org/10.3390/pharmaceutics15020492 Abstract
Sánchez-Hidalgo M, García MJ, González I, Oves-Costales D, Genilloud O. Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters. Microorganisms. 2023; 11(2):265. https://doi.org/10.3390/microorganisms11020265 Abstract
Díaz C, González-Olmedo C. Untargeted Metabolomics by Liquid Chromatography-Mass Spectrometry in Biomedical Research. Methods in Molecular Biology. 2023;2571:57-69. doi: 10.1007/978-1-0716-2699-3_6. Abstract
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D. Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa. Journal of Medicinal Chemistry. 2023 Jan 12. doi: 10.1021/acs.jmedchem.2c01597 Abstract
Gattoni G, de la Haba RR, Martín J, Reyes F, Sánchez-Porro C, Feola A, Zuchegna C, Guerrero-Flores S, Varcamonti M, Ricca E, Selem-Mojica N, Ventosa A and Corral P. Genomic study and lipidomic bioassay of Leeuwenhoekiella parthenopeia: A novel rare biosphere marine bacterium that inhibits tumor cell viability. Frontiers in Microbiology. 13:1090197. doi: 10.3389/fmicb.2022.1090197 Abstract
Oves-Costales D, Gren T, Baggesgaard Sterndorff E, Martín J, Ortiz-López FJ, Jørgensen TS, Jiang X, Román-Hurtado F, Reyes F, Genilloud O, Weber T. Identification and heterologous expression of the globomycin biosynthetic gene cluster. Synthetic and Systems Biotechnology. Volume 8, Issue 2, 2023, Pages 206-212. https://doi.org/10.1016/j.synbio.2023.02.001. Abstract
Diyaolu OA, Preet G, Fagbemi AA, Annang F, Pérez-Moreno G, Bosch-Navarrete C, Adebisi OO, Oluwabusola ET, Milne BF, Jaspars M, Ebel R. Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria. Antibiotics (Basel). 2023 Jan 6;12(1):109. doi: 10.3390/antibiotics12010109 Abstract
dos Santos JDN, João SA, Martín J, Vicente F, Reyes F, Lage OM. iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments. Microorganisms. 2022; 10(7):1471. https://doi.org/10.3390/microorganisms10071471 Abstract
Jimenez L, Amenabar C, Mayoral-Varo V, Mackenzie TA, Ramos MC, Silva A, Calissi G, Grenho I, Blanco-Aparicio C, Pastor J, Megías D, Ferreira BI, Link W. mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity. Molecules. 2022; 27(17):5414. https://doi.org/10.3390/molecules27175414 Abstract
Rodríguez-Ruiz M, Ramos C, Campos MJ, Vicente F, Corpas FJ, Palma JM. Crude extracts from pepper fruits show anti-proliferative activity against tumor cells altering their catalase and glucose-6-phosphate dehydrogenase profile. Free Radical Biology and Medicine, 2022, Vol 189, Supplement 1, 40-41. https://doi.org/10.1016/j.freeradbiomed.2022.06.172 Abstract
Rodríguez-Ruiz M, Pérez de Palacio J, González-Gordo S, Díaz C, Ramos C, Vicente F, Palma JM, Corpas FJ. Compounds from sweet pepper (Capsicum annuum l.) fruits with potential therapeutic uses are boosted by nitric nitric oxide (NO). Free Radical Biology and Medicine, 2022, Vol 189, Supplement 1, 41, https://doi.org/10.1016/j.freeradbiomed.2022.06.173 Abstract
Virués-Segovia JR, Reyes F, Ruíz S, Martín J, Fernández-Pastor I, Justicia C, de la Cruz M, Díaz C, Mackenzie TA, Genilloud O, González I, Tormo JR. Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens. Molecules. 2022; 27(19):6355. https://doi.org/10.3390/molecules27196355 Abstract
Riccio G, Martinez KA, Martín J, Reyes F, D’Ambra I, Lauritano C. Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds. Marine Drugs. 2022 May 25;20(6):350. doi: 10.3390/md20060350. Abstract
Nielsen JB, Gren T, Mohite OS, Jørgensen TS, Klitgaard AK, Mourched AS, Blin K, Oves-Costales D, Genilloud O, Larsen TO, Tanner D, Weber T, Gotfredsen CH, Charusanti P. Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp. ACS Chemical Biology. 2022 Sep 16;17(9):2411-2417. doi: 10.1021/acschembio.2c00480. Abstract
Liang H, Lopez IJ, Sánchez-Hidalgo M, Genilloud O, van der Donk WA. Mechanistic Studies on Dehydration in Class V Lanthipeptides. ACS Chemical Biology. 2022 Sep 16;17(9):2519-2527. doi: 10.1021/acschembio.2c00458 Abstract
Díaz C, González-Olmedo C. Untargeted Metabolomics by Liquid Chromatography-Mass Spectrometry in Biomedical Research. Methods in Molecular Biology. 2023;2571:57-69. doi: 10.1007/978-1-0716-2699-3_6 Abstract
Pérez-Victoria I, Crespo G, Reyes F. Expanding the utility of Marfey’s analysis by using HPLC-SPE-NMR to determine the Cβ configuration of threonine and isoleucine residues in natural peptides. Analytical and Bioanalytical Chemistry. 2022 Nov;414(28):8063-8070. doi: 10.1007/s00216-022-04339-2 Abstract
Navarro JA, Díaz C, Decara J, Medina-Vera D, Lopez-Gambero AJ, Suarez J, Pavón FJ, Serrano A, Vargas A, Gavito AL, Porras-Perales O, Aranda J, Vicente F, Sanjuan C, Baixeras E, Fonseca FR. Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers. Nutrients. 2022 Oct 1;14(19):4094. doi: 10.3390/nu14194094 Abstract
Ye S, Ballin G, Pérez-Victoria I, Braña AF, Martín J, Reyes F, Salas JA, Méndez C. Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus. Applied Microbiology International. 2022 Nov 8. doi: 10.1111/1751-7915.14167 Abstract
Sarmiento-Vizcaíno A, Martín J, Ortiz-López FJ, Reyes F, García LA, Blanco G. Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin. Frontiers in Chemistry. 2022 Nov 3;10:948795. doi: 10.3389/fchem.2022.948795 Abstract
Vitorino IR, Lobo-da-Cunha A, Vasconcelos V, Vicente F, Lage OM. Isolation, diversity and antimicrobial activity of planctomycetes from the Tejo river estuary (Portugal). FEMS Microbiology Ecology, fiac066, https://doi.org/10.1093/femsec/fiac066. Abstract
Ortiz-Gonzalez M, Pérez-Victoria I, Ramirez-Macias I, De Pedro N, Linde-Rodriguez A, González-Menéndez V, Sanchez-Martin V, Martín J, Soriano-Lerma A, Genilloud O, Perez-Carrasco V, Vicente F, Maceira J, Rodrígues-Poveda CA, Navarro-Marí JM, Reyes F, Soriano M, Garcia-Salcedo JA. Curvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcription. International Journal of Molecular Sciences. 2022; 23(11):6107. https://doi.org/10.3390/ijms23116107 Abstract
Santamaría R I, Martínez-Carrasco A, Martín J, Tormo J R, Pérez-Victoria I, González I, Genilloud O, Reyes F, Díaz M. Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp. Antibiotics. 2022, 11(5), 672; https://doi.org/10.3390/antibiotics11050672 Abstract
Bagán A, Morales-García JA, Griñán-Ferré C, Díaz C, Pérez del Palacio J, Ramos MC, Vicente F, Pérez B, Brea J, Loza MI, Pallàs M, Escolano C. Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06. International Journal of Molecular Sciences. 2022; 23(10):5408. https://doi.org/10.3390/ijms23105408 Abstract
Riccio G, Martinez KA, Ianora A, Lauritano C. De Novo Transcriptome of the Flagellate Isochrysis galbana Identifies Genes Involved in the Metabolism of Antiproliferative Metabolites. Biology. 2022; 11(5):771. https://doi.org/10.3390/biology11050771 Abstract
Reyes F, Bills GF, Durán-Patrón R. Editorial: Strategies for the Discovery of Fungal Natural Products. Frontiers in Microbiology. 2022, Vol. 13. DOI=10.3389/fmicb.2022.897756. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus. Natural Product Research. 2022 Apr;36(8):2043-2048. doi:10.1080/14786419.2020.1844699. Abstract
Slemc L, Jakše J, Filisetti A, Baranasic D, Rodríguez-García A, Del Carratore F, Marino SM, Zucko J, Starcevic A, Šala M, Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Reyes F, Genilloud O, Springthorpe V, Goranovič D, Kosec G, Thomas GH, Lucrezia D, Petković H, Tome M. Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing. Microbiology Spectrum. 2022 Apr 4:e0243421. doi: 10.1128/spectrum.02434-21. Abstract
Machushynets N, Elsayed S, Du C, Siegler M, de la Cruz M, Genilloud O, Hankemeier T, van Wezel G. Discovery of actinomycin L, a new member of the actinomycin family of antibiotics. Scientific Reports, (2022), 2813, 12(1). https://doi.org/10.1038/s41598-022-06736-0 Abstract
Martinez JC, Castillo F, Ruiz-Sanz J, Murciano-Calles J, Camara-Artigas A, Luque I. Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families. Advances in Protein Chemistry and Structural Biology. ELSEVIER. 2022 Jan 10. https://doi.org/10.1016/bs.apcsb.2021.12.002. Abstract
Prado-Alonso L, Pérez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147. Applied and Environmental Microbiology, 2022;88:e01839-21 https://journals.asm.org/doi/10.1128/AEM.01839-21 Abstract
Carretero-Molina D, Ortiz-López FJ, Gren T, Oves-Costales D, Martín J, Román-Hurtado F, Jørgensen TS, de la Cruz M, Díaz C, Vicente F, Blin K, Reyes F, Weber T, Genilloud O. Discovery of gargantulides B and C, new 52-membered macrolactones from Amycolatopsis sp. Complete absolute stereochemistry of the gargantulide family. Organic Chemistry Frontiers 2022; 9:462-70. https://doi.org/10.1039/D1QO01480C Abstract
Martínez KA, Saide A, Crespo G, Martín J, Romano G, Reyes F, Lauritano C, Iannora A. Promising Antiproliferative Compound from the Green Microalga Dunaliella tertiolecta Against Human Cancer Cells. Frontiers in Marine Science 2022; 9:778108. https://doi.org/10.3389/fmars.2022.778108 Abstract
Gimranov E, Santos JDN, Vitorino I, Martín J, Reyes F, Moura L, Tavares F, Santos C, Mariz-Ponte N, Lage OM. Marine bacterial activity against phytopathogenic Pseudomonas show high efficiency of Planctomycetes extracts. European Journal of Plant Pathology 2022; 162:843-54. https://doi.org/10.1007/s10658-021-02441-2 Abstract
Díaz C, González-Olmedo C, Díaz-Beltrán L, Camacho J, Mena García P, Martín-Blázquez A, Fernández-Navarro M, Ortega-Granados AL, Gálvez-Montosa F, Marchal JA, Vicente F, Pérez Del Palacio J, Sánchez-Rovira P. Predicting Dynamic response to neoadjuvant chemotherapy in breast cancer: a novel metabolomics approach. Molecular Oncology. 2022 Mar 26. doi: 10.1002/1878-0261.13216. Abstract
Ganesan A, Aldholmi M, Ahmad R, Carretero-Molina D, Pérez-Victoria I, Martín J, Reyes F, Genilloud O, Gourbeyre L, Gefflaut T, Carlsson H, Maklakov A, Field RA, O’Neill E, Wilkinson B, O’Connell M. Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis. Angewandte Chemie International Edition. 2022 Mar 24. doi: 10.1002/anie.202203175. Abstract
Schnegotzki R, Wiebach V, Sánchez-Hidalgo M, Tietzmann M, Zur Bonsen AB, Genilloud O, Süssmuth RD. Total Synthesis and Biosynthesis of Cyclodepsipeptide Cochinmicin I. Organic Letters. 2022 Mar 21. doi: 10.1021/acs.orglett.2c00525. Abstract
Pérez I, Campos-Pardos E, Díaz C, Uranga S, Sayes F, Vicente F, Aguiló N, Brosch R, Martín C, Gonzalo-Asensi J. The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy. Molecular Therapy: Nucleic Acids. 2022, Vol. 27 1235 – 1248. DOI: https://doi.org/10.1016/j.omtn.2022.02.011 Abstract
Castillo F, Corbi-Verge C, Murciano-Calles J, Candel A m, Han Z, Iglesias-Bexiga M, Ruiz-Sanz J, Kim P M, Harty R n, Martinez J C, Luque I. Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals. International Journal of Biological Macromolecules, 2022. Volume 207, 15 May 2022, Pages 308-323. DOI: https://doi.org/10.1016/j.ijbiomac.2022.03.010. Abstract
Georgousaki K, González-Menéndez V, Tormo JR, Tsafantakis N, Mackenzie TA,
Martín J, Gumeni S, Trougakos IP, Reyes F, Fokialakis N, Genilloud O. Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants. Scientifc Reports. 2022 Jan 31;12(1):1649. doi: 10.1038/s41598-022-05448-9. Abstract
Moo-Koh FA, Cristóbal-Alejo J, Andrés MF, Martín J, Reyes F, Tun-Suárez JM, Gamboa-Angulo M. In Vitro Assessment of Organic and Residual Fractions of Nematicidal Culture Filtrates from Thirteen Tropical Trichoderma Strains and Metabolic Profiles of Most-Active. Journal of Fungi (Basel). 2022 Jan 15;8(1):82. doi: 10.3390/jof8010082. Abstract
Wang X, Serrano R, González-Menéndez V, Mackenzie TA, Ramos MC, Frisvad JC, Larsen TO. A Molecular Networking Based Discovery of Diketopiperazine Heterodimers and Aspergillicins from Aspergillus caelatus. Journal of Natural Products. 2022 Jan 28;85(1):25-33. doi: 10.1021/acs.jnatprod.1c00526. Abstract
Miguel-Gordo M, Reddy MM, Sánchez P, Buckley JJ, Mackenzie TA, Jennings LK, Reyes F, Calabro K, Thomas OP. Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands. Organic & Biomolecular Chemistry. 2022 Jan 12. doi: 10.1039/d1ob02297k. Abstract
Parra-Millán R, Jiménez-Mejías ME, Ayerbe-Algaba R, Domínguez-Herrera J, Díaz C, Pérez Del Palacio J, Pachón J, Smani Y. Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy. Enfermedades infecciosas y microbiologia clinica (English ed.). 2022 Jan;40(1):14-21. doi: 10.1016/j.eimce.2020.06.019. Abstract
Álvarez-Caballero JM, Cuca-Suárez LE, Coy-Barrera E, Carrasco-Pancorbo A, Olmo-García L, Martin J, Cruz M, Peŕez-Victoria I, Reyes F. Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea. American Chemical Society Omega. 2021 Nov 23;6(48):32631-32636. doi: 10.1021/acsomega.1c04255. Abstract
Annang F, Pérez-Moreno G, Díaz C, González-Menéndez V, de Pedro Montejo N, Del Palacio JP, Sánchez P, Tanghe S, Rodriguez A, Pérez-Victoria I, Cantizani J, Ruiz-Pérez LM, Genilloud O, Reyes F, Vicente F, González-Pacanowska D. Preclinical evaluation of strasseriolides A-D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251. Malar J. 2021 Dec 5;20(1):457. doi: 10.1186/s12936-021-03993-8. Abstract
Sarmiento-Vizcaíno A, Martín J, Reyes F, García LA, Blanco G. Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain. Front Microbiol. 2021, 12:773095. Abstract
Beck C, Gren T, Ortiz-López FJ, Jørgensen T S, Carretero-Molina D, Martín Serrano J, Tormo JR, Oves-Costales D, Kontou E E, Mohite OS, Mingyar E, Stegmann E, Genilloud O, Weber T. Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods. Molecules 2021, 26, 6580. Abstract
Vitorino I, Santos JDN, Godinho O, Vicente F, Vasconcelos V, Lage OM. Novel and Conventional Isolation Techniques to Obtain Planctomycetes from Marine Environments. Microorganisms. 2021 Oct 1;9(10):2078. doi: 10.3390/microorganisms9102078. Abstract
Prado-Alonso L, Pérez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Colibrimycins, novel halogenated hybrid PKS-NRPS compounds produced by Streptomyces sp. CS147. Appl Environ Microbiol. 2021 Oct 20:AEM0183921. doi: 10.1128/AEM.01839-21. Abstract
Oluwabusola ET, Adebisi OO, Reyes F, Acquah KS, De La Cruz M, Mweetwa LL, Rajakulendran JE, Warner DF, Hai D, Ebel R, Jaspars M. Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B. Beilstein J Org Chem. 2021 Sep 13;17:2390-2398.
doi: 10.3762/bjoc.17.156. Abstract
Díaz C, Jiménez-Luna C, Diéguez-Castillo C, Martín A, Prados J, Martín-Ruíz JL, Genilloud O, Vicente F, Pérez Del Palacio J, Caba O. Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis. Medicina (Kaunas). 2021 Aug 26;57(9):876. doi: 10.3390/medicina57090876. Abstract
Jørgensen TS, Gren T, Oves-Costales D, Ortiz-López FJ, Carretero-Molina D, González I, Blin K, Genilloud O, Weber T. Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a 35-Module Type I Polyketide Synthase. Microbiol Resour Announc. 2021 Sep 23;10(38):e0080521. doi: 10.1128/MRA.00805-21. Abstract
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Towards the sustainable discovery and development of new antibiotics. Nat Rev Chem. 2021 Aug 19:1-24. doi: 10.1038/s41570-021-00313-1. Abstract
Jørgensen TS, Gren T, Kontou EE, González I, Román-Hurtado F, Oves-Costales D, Thomsen E, Charusanti P, Genilloud O, Weber T. Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp. Strain CA-103260. Microbiol Resour Announc. 2021 Jul 29;10(30):e0049921. doi: 10.1128/MRA.00499-21. Abstract
Kontou EE, Gren T, Ortiz-López FJ, Thomsen E, Oves-Costales D, Díaz C, de la Cruz M, Jiang X, Jørgensen TS, Blin K, Charusanti P, Reyes F, Genilloud O, Weber T. Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260. ACS Chem Biol. 16(8):1456-1468. doi:10.1021/acschembio.1c00318. Abstract
Juhasz B, Pech-Puch D, Tabudravu JN, Cautain B, Reyes F, Jiménez C, Kyeremeh K, Jaspars M. Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV-Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1 T. Mar Drugs. 2021 Jun 3;19(6):325. doi: 10.3390/md19060325. Abstract
Del Carratore F, Iorio M, Pérez-Bonilla M, Schmidt K, Pérez-Redondo R, Sosio M, Macdonald SJ, Gyulev IS, Tsigkinopoulou A, Thomas GH, Genilloud O, Rodríguez-García A, Donadio S, Breitling R, Takano E. Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A. mSystems. 6(3):e0034121. doi: 10.1128/mSystems.00341-21. Abstract
Serrano R, González-Menéndez V, Martínez G, Toro C, Martín J, Genilloud O, Tormo R. Metabolomic Analysis of The Chemical Diversity of South Africa Leaf Litter Fungal Species Using an Epigenetic Culture-Based Approach. Molecules. 2021; 26(14):4262. https://doi.org/10.3390/molecules26144262 Abstract
Beck C, Gren T, Jørgensen TS, González I, Román-Hurtado F, Oves-Costales D, Genilloud O, Weber T. Complete Genome Sequence of Streptomyces sp. Strain CA-256286. Microbiol Resour Announc. 2021 Jun 3;10(22):e0029021. doi:10.1128/MRA.00290-21. Abstract
Breitling R, Avbelj M, Bilyk O, Carratore FD, Filisetti A, Hanko EKR, Iorio M, Redondo RP, Reyes F, Rudden M, Severi E, Slemc L, Schmidt K, Whittall DR, Donadio S, García AR, Genilloud O, Kosec G, De Lucrezia D, Petković H, Thomas G,Takano E. Synthetic biology approaches to actinomycete strain improvement. FEMS Microbiol Lett. 2021 Jun 11;368(10): fnab060. doi: 10.1093/femsle/fnab060. Abstract
Navarro-Marchal SA, Griñán-Lisón C, Entrena JM, Ruiz-Alcalá G, Tristán-Manzano M, Martin F, Pérez-Victoria I, Peula-García JM, Marchal JA. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 2021 Apr 12;22(4):1374-1388. doi:10.1021/acs.biomac.0c01546. Abstract
Guevara L, Domínguez-Anaya MÁ, Ortigosa A, González-Gordo S, Díaz C, Vicente F, Corpas FJ, Pérez Del Palacio J, Palma JM. Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO). Int J Mol Sci. 2021 Apr 25;22(9):4476. doi: 10.3390/ijms22094476. Abstract
Guo Y, Ding L, Ghidinelli S, Gotfredsen CH, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Coriani S, Larsen RW, Frisvad JC, Larsen TO. Taxonomy Driven Discovery of Polyketides from Aspergillus californicus. J Nat Prod. 2021 Apr 23;84(4):979-985. doi: 10.1021/acs.jnatprod.0c00866. Abstract
Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López F J, Genilloud O. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs. Antibiotics, (2021), 403, 10(4) doi: 10.1101/2020.05.20.105809. Abstract
Cebrero-Cangueiro T, Labrador-Herrera G, Pascual Á, Díaz C, Rodríguez-Baño J, Pachón J, del Palacio JP, Pachón-Ibáñez ME and Conejo MC . Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains. Front. Med. 8:615540. doi: 10.3389/fmed.2021.615540. Abstract
Carretero-Molina D, Ortiz-López FJ, Martín J, González I, Sánchez-Hidalgo M, Román-Hurtado F, Díaz C, de la Cruz M, Genilloud O, Reyes F. Pentaminomycins F and G, Nonribosomal Peptides Containing 2-Pyridylalanine. J Nat Prod. 2021 , 84, 4, 1127-1134. doi: 10.1021/acs.jnatprod.0c01199. Epub ahead of print. Abstract
Herath KB, Previs SF, Roddy TP, Attygalle AB, González I, Genilloud O, Singh SB. Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry. J Nat Prod. 2021 Mar 26;84(3):814-823. doi: 10.1021/acs.jnatprod.0c01190. Abstract
Navarro-Marchal SA, Griñán-Lisón C, Entrena JM, Ruiz-Alcalá G, Tristán- Manzano M, Martin F, Pérez-Victoria I, Peula-García JM, Marchal JA. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 2021 Apr 12;22(4):1374-1388. doi: 10.1021/acs.biomac.0c01546. Abstract
Fernández-Pastor, I.; González-Menéndez, V.; Annang, F.; Toro, C.; Mackenzie, T.A.; Bosch-Navarrete, C.; Genilloud, O.; Reyes, F. Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae. Pharmaceuticals 2021, 14, 268. https://doi.org/10.3390/ph14030268, 14(3), 268; Abstract
Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, Gonzalez-Menendez V, Genilloud O, Trougakos IP, Fokialakis N, Ouazzani J. Elastase inhibitory activity of secondary metabolites from the fungus Virgaria nigra CF-231658. Nat Prod Res. 2021 Mar 11:1-4. doi: 10.1080/14786419.2021.1899175. Abstract
Rotter A, Barbier M, Bertoni F, Bones AM, Cancela ML, Carlsson J, Carvalho MF, Cegłowska M, Chirivella-Martorell J, Conk DM, Cueto M, Dailianis T, Deniz I, Díaz-Marrero AR, Drakulovic D, Dubnika A, Edwards C, Einarsson H, Erdoan A, Eroldoan OT, Ezra D, Fazi S, FitzGerald RJ, Gargan LM, Gaudêncio SP, Gligora UM, Ivosevic DeNardis N, Jónsdóttir R, Katarzytė M, Klun K, Kotta J, Ktari L, Ljubesic Z, Lukic Bilela L, Mandalakis M, Massa-Gallucci A, Matijosytė I, Mazur-Marzec H, Mehiri M, Nielsen Søren L, Novoveská L, Overlingė D, Perale G, Ramasamy P, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Röttinger E, Rudovica V, Sabotic J, Safarik I, Talve S, Tasdemir D, Theodotou Schneider X, Thomas OP, Toruńska-Sitarz A, Varese GC, Vasquez MI. The Essentials of Marine Biotechnology. Front. Mar. Sci., (2021), 158, 8. DOI:10.3389/fmars.2021.629629. Abstract
Silvestri A, Vicente F, Vicent MJ, Stechmann B, Fecke W. Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery. Drug Discov Today. (2021) 1369-1381, 26(6). doi: 10.1016/j.drudis.2021.02.024. Abstract
García-Padilla C, Lozano-Velasco E, López-Sánchez C, Garcia-Martínez V, Aranega A, Franco D. Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers. Noncoding RNA. 2021 Feb 17;7(1):13. doi: 10.3390/ncrna7010013. Abstract
Palacios-Ferrer JL, García-Ortega MB, Gallardo-Gómez M, García MÁ, Díaz C, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias-Santiago S, Amezcua V, Peinado H, Vicente F, Pérez Del Palacio J, Marchal JA. Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma.Mol Oncol. 2021 Feb;15(2):407-428. doi: 10.1002/1878-0261.12823. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. New naphthyl derivatives from Aspergillus californicus. J Antibiot. 74, 111–114 (2021). doi: 10.1038/s41429-020-00372-4. Abstract
Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP, van der Donk WA. New developments in RiPP discovery, enzymology and engineering. Nat. Prod. Rep., 2021,38, 130-239. doi: 10.1039/d0np00027b. Abstract
Gavriilidou, A.; Mackenzie, T.A.; Sánchez, P.; Tormo, J.R.; Ingham, C.; Smidt, H.; Sipkema, D. Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria. Mar. Drugs 2021, 19, 75. https://doi.org/10.3390/md19020075 Abstract
Subko K, Wang X, Nielsen FH, Isbrandt T, Gotfredsen CH, Ramos MC, Mackenzie T, Vicente F, Genilloud O, Frisvad JC, Larsen TO. Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility. Front Microbiol. 2021 Jan 15;11:618730. doi: 10.3389/fmicb.2020.618730. Abstract
Subko K, Kildgaard S, Vicente F, Reyes F, Genilloud O, Larsen TO. Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Stilbella fimetaria. Mar Drugs. 2021 Jan 20; 19(2), 46. doi: 10.3390/md19020046. Abstract
Díaz-Beltrán L, González-Olmedo C, Luque-Caro N, Díaz C, Martín-Blázquez A, Fernández-Navarro M, Ortega-Granados AL, Gálvez-Montosa F, Vicente F, Pérez Del Palacio J, Sánchez-Rovira P. Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer. Cancers (Basel). 2021 Jan 5;13(1):147. doi:10.3390/cancers13010147. Abstract
Pérez-Victoria I. Co-occurring congeners reveal the position of enantiomeric amino acids in nonribosomal peptides. Chembiochem. 2021 Jan 13. doi: 10.1002/cbic.202000805. Abstract
Méndez-Luna D, Morelos-Garnica LA, García-Vázquez JB, Bello M, Padilla-Martínez II, Fragoso-Vázquez MJ, Dueñas González A, De Pedro N, Gómez-Vidal JA,Mendoza-Figueroa HL, Correa-Basurto J. Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells. Pharmaceuticals (Basel). 2021 Jan 10;14(1):49. doi: 10.3390/ph14010049. Abstract
Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López FJ, Carretero-Molina D, Reyes F, Genilloud O. One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360. Microorganisms. 2021 Jan 8;9(1):135. doi: 10.3390/microorganisms9010135. Abstract
Elamine Y, Lyoussi B, Miguel MG, Anjos O, Estevinho L, Alaiz M, Girón-Calle J, Martín J, Vioque J. Physicochemical characteristics and antiproliferative and antioxidant activities of Moroccan Zantaz honey rich in methyl syringate. Food Chem. 2021 Mar 1;339:128098. doi: 10.1016/j.foodchem.2020.128098. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus. Nat Prod Res. 2020 Nov 9:1-6. doi: 10.1080/14786419.2020.1844699. Abstract
Jimenez-Luna C, Martin-Blazquez A, Dieguez-Castillo C, Diaz C, Martin-Ruiz JL, Genilloud O, Vicente F, Del Palacio JP, Prados J, Caba O. Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics. Metabolites. 2020 Oct 22;10(11):423. doi: 10.3390/metabo10110423. Abstract
Calabro K, Jennings LK, Lasserre P, Doohan R, Rodrigues D, Reyes F, Ramos C, Thomas OP. Nebulosins: Trisubstituted Thiolane Natural Products from the Northeastern Atlantic Annelid Eupolymnia nebulosa. J Org Chem. 2020, 85, 21, 14026–14041. Abstract
Jimenez-Luna C, Martin-Blazquez A, Dieguez-Castillo C, Diaz C, Martin-Ruiz JL, Genilloud O, Vicente F, Del Palacio JP, Prados J, Caba O. Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics. Metabolites. 2020 Oct 22;10(11):E423. Abstract
Cruz-Cerino P, Cristóbal-Alejo J, Ruiz-Carrera V, Carnevali G, Vera-Ku M, Martín J, Reyes F, Gamboa-Angulo M. Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense. Pathogens. 2020 Oct 10;9(10):E827. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. New naphthyl derivatives from Aspergillus californicus. J Antibiot 74, 111–114 (2021). Abstract
Pérez-Bonilla M, Oves-Costales D, González I, de la Cruz M, Martín J, Vicente F, Genilloud O, Reyes F. Krisynomycins, Imipenem Potentiators against Methicillin-Resistant Staphylococcus aureus, Produced by Streptomyces canus. J Nat Prod. 2020, 83,9,2597-2606. Abstract
Annang F, Pérez-Moreno G, González-Menéndez V, Lacret R, Pérez-Victoria I,Martín J, Cantizani J, de Pedro N, Choquesillo-Lazarte D, Ruiz-Pérez LM,González-Pacanowska D, Genilloud O, Vicente F, Reyes F. Strasseriolides A-D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251. Org Lett. 2020, 22, 17, 6709–6713. Abstract
Bekiesch P, Zehl M, Domingo-Contreras E, Martín J, Pérez-Victoria I, Reyes F, Kaplan A, Rückert C, Busche T, Kalinowski J, Zotchev SB. Viennamycins: Lipopeptides Produced by a Streptomyces sp. J. Nat. Prod. 2020, 83, 8, 2381–2389. Abstract
Diogo Santos J, Vitorino I, Reyes F, Vicente F, Lage O M. From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria. Antibiotics 2020, 9(8), 455; Abstract
Oluwabusola ET, Tabudravu JN, Al Maqbali KS, Annang F, Pérez-Moreno G, Reyes F, Jaspars M. Antiparasitic activity of bromotyrosine alkaloids and new analogues isolated from the Fijian marine Sponge Aplysinella rhax. Chem Biodivers. 2020 Jul 22. doi: 10.1002/cbdv.202000335. Abstract
Parra-Millán R, Jiménez-Mejías ME, Ayerbe-Algaba R, Domínguez-Herrera J, Díaz C, Pérez Del Palacio J, Pachón J, Smani Y. Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy. Enferm Infecc Microbiol Clin. 2020 Jul 13:S0213-005X(20)30233-0. Abstract
Sánchez-Hidalgo M, Pascual J, González I, Genilloud O. Draft Genome Sequenceand Biosynthetic Potential of the Newly Described Strain Longimicrobium terrae CB-286315. Microbiol Resour Announc. 2020 Jun 11;9(24):e00512-20.
Abstract
Tienaho J, Karonen M, Muilu-Mäkelä R, Kaseva J, de Pedro N, Vicente F,Genilloud O, Aapola U, Uusitalo H, Vuolteenaho K, Franzén R, Wähälä K, Karp M,Santala V, Sarjala T. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots. Planta Med. 2020 ; 86(13/14): 1009-1024. Abstract
Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López F J, Genilloud O. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs. bioRxiv. doi: 10.1101/2020.05.20.105809. Abstract
Ortiz-López FJ, Carretero-Molina D, Sánchez-Hidalgo M, Martín J, González I, Román-Hurtado F, De la Cruz M, García-Fernández S, Reyes F, Deisinger JP, Müller A, Schneider T & Genilloud O. Cacaoidin, First Member of the New Lanthidin RiPP Family. Angewandte Chemie International Edition 2020; doi.org/10.1002/anie.202005187 Abstract
Becerril A, Pérez-Victoria I, Ye S, Braña AF,Martín J, Reyes F, Salas JA, and Méndez C. Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family. ACS Chem. Biol. 2020, 15, 6, 1541–1553; Abstract
Corpas-López V, Tabraue-Chávez M, Sixto-López Y, Panadero-Fajardo S, Alves de Lima Franco F, Domínguez-Seglar JF, Morillas-Márquez F, Franco-Montalbán F, Díaz-Gavilán M, Correa-Basurto J, López-Viota J, López-Viota M, Pérez Del Palacio J, de la Cruz M, de Pedro N, Martín-Sánchez J, Gómez-Vidal JA. O-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity. J Med Chem. 2020 Jun 11;63(11):5734-5751.
Abstract
Crespo G, Pérez-Victoria I, Ortiz-López FJ, González-Menéndez V, De la Cruz M, Cautain B, Sánchez P, Vicente F, Genilloud O and Reyes F. Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens. Antibiotics 2020, 9(6), 278. Abstract
Cabello-Donayre M, Orrego LM, Herráez E, Vargas P, Martínez-García M, Campos-Salinas J, Pérez-Victoria I, Vicente B, Marín JJG, Pérez-Victoria JM. Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite. Cell. Mol. Life Sci., 77, pages1827–1845(2020). Abstract
Rotter A, Bacu A, Barbier M, Bertoni F, Bones A M, Cancela M L, Carlsson J, Carvalho M F, Cegłowska M, Dalay M C, Dailianis T, Deniz I, Drakulovic D, Dubnika A, Einarsson H, Erdoğan A, Eroldoğan O T, Ezra D, Fazi S,FitzGerald R J, Gargan L M, Gaudêncio S P, DeNardis N I, Joksimovic D, Kataržytė M, Kotta J, Mandalakis M, Matijošytė I, Mazur-Marzec H, Massa-Gallucci A, Mehiri M, Nielsen S L, Novoveská L, Overlingė D, Portman M E, Pyrc K, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Rudovica V, Sabotič J, Safarik I, Talve S, Tasdemir D, Schneider X T, Thomas OP, Toruńska-Sitarz A, Varese G C, Vasquez . A new network for the advancement of marine biotechnology in Europe and beyond. Front. Mar. Sci., 2020; 7:278. Abstract
Martín-Blázquez A, Jiménez-Luna C,Díaz C, Martínez-Galán J, Prados J, Vicente F, Melguizo C, Genilloud O, Pérez del Palacio J, Caba O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers, 2020, 12(4), 1002. Abstract
Berenguel Hernández A M., De la Cruz M, Alcázar-Fabra M, Prieto-Rodríguez A, Sánchez-Cuesta A, Martin J, Tormo J R, Rodríguez-Aguilera J C, Cortés-Rodríguez A B, Navas P, Reyes F, Vicente F, Genilloud O, Santos-Ocaña C. Design of high-throughput screening of natural extracts to identify molecules bypassing primary coenzyme Q deficiency in Saccharomyces cerevisiae. SLAS Discov., 2020, 25, 299-309. Abstract
Salamanca-Fernández E,Rodríguez-Barranco M, Arrebola JP, Vela F, Díaz C, Chirlaque M D, Colorado-Yohar S, Jiménez-Zabala A, Irizar A, Guevara M, Ardanaz E, Iribarne-Durán LM, Pérez del Palacio J, Olea N, Agudo A, Sánchez MJ. Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors. Environmental Research,2020, 182, 109012. Abstract
Lauritano C, Martínez K A, Battaglia P, Granata A, De la Cruz M, Cautain B, Martín J, Reyes F, Ianora A, Guglielmo L. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Sci Rep., 10, 4929 (2020). Abstract
Diogo Santos J, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez I, Tormo J R, Martin J, Vicente MF, Lage OM. Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges. Antonie van Leeuwenhoek, 113, pages875–887(2020). Abstract
Sánchez-Hidalgo M, Martín J, Genilloud O. Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator. Antibiotics, 2020, 9(2), 67. Abstract
Georgousaki K, Tsafantakis N, Gumeni S, Lambrinidis G, González-Menéndez V, Tormo JR, Genilloud O, Trougakos IP, Fokialakis N. Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules. Molecules, 2020, 25(3), 666. Abstract
Fang Q , Maglangit F , Wu L, Ebel R, Kyeremeh K, Andersen JH, Annang F, Pérez-Moreno G,Reyes F, Deng H. Signalling and Bioactive Metabolites from Streptomyces sp. RK44, Molecules, 2020, 25(3), 460. Abstract
Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Generation of new sipanmycin analogues by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway. Appl. Environ. Microbiol., 2020, 86, e02453-19. Abstract
Georgousaki, K., Tsafantakis, N., Gumeni, S., Gonzalez, I., Andrew Mackenzie, T., Reyes F., Lambert, C., Trougakos, I.P., Genilloud, O., Fokialakis, N., Screening for tyrosinase inhibitors from actinomycetes; Identification of trichostatin derivatives from Streptomyces sp. CA-129531 and scale up production in bioreactor. Bioorg Med Chem Lett., 2020, 15;30(6):126952. Abstract
Romain Koagne R, Annang F, Cautain B, Martín J, Pérez-Moreno G, Thierry M. Bitchagno G, González-Pacanowska D, Vicente F, Konga Simo I, Reyes F & Tane P. Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae). BMC Complementary Medicine and Therapies, 2020,15;20(1):8. Abstract
Carretero-Molina D, Ortiz-López F J, Martín J, Oves-Costales D, Díaz C, De la Cruz M, Cautain B, Vicente F, Genilloud O, Reyes F. New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078. Mar. Drugs, 2020, 18(1), 22. Abstract
Mazzotta S, Marrugal-Lorenzo J A, Vega-Holm M, Serna-Gallego A, Álvarez-Vidal J, Berastegui-Cabrera J, Pérez del Palacio J, Díaz C, Aiello F, Pachón J,Iglesias-Guerra F,Vega-Pérez J M, Sánchez-Céspedes J. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents. Eur J Med Chem., 2020, 1;185. Abstract
Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer. Sci Rep., 9, 20198 (2019). Abstract
Almeida C, Mackenzie TA, González-Menendez V, De Pedro N, Pérez-Victoria I, Crespo G, Martín J, Genilloud O, Vicente F, Cautain B, Reyes F. Laccaridione C, a Bioactive Polyketide from the Fungus Montagnula sp. PMIO, 2019; 6(02): e57-e62. Abstract
Barúa JE, De la Cruz M, De Pedro N, Cautain B, Hermosa R, Cardoza RE, Gutiérrez S, Monte E, Vicente F, Collado IG. Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities. Molecules, 2019, 24, 3811 Abstract
Tejman-Yarden N, Robinson A, Davidov Y, Shulman A, Varvak A, Reyes F, Rahav G, Nissan I. Delftibactin-A, a Non Ribosomal Peptide with Broad Antimicrobial Activity. Front. Microbiol., 10:2377 doi: 10.3389/fmicb.2019.02377. Abstract
Reina JC, Pérez-Victoria I, Martín J, Llamas I. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar. Drugs, 2019, 17: 494. Abstract
González-Menéndez V, Crespo G, Toro C, Martín J, de Pedro N, Tormo JR, Genilloud O. Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani. Metabolites, 2019, 9: 197. Abstract
Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, González I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J. Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. Molecules, 2019, 24: 2239. Abstract
Peyrat L-A, Tsafantakis N, Georgousaki K, Ouazzani J, Genilloud O, Trougakos IP, Fokialakis N. Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications. Molecules, 2019, 24: 1836. Abstract
Georgousaki K, Tsafantakis N, Gumeni S, González-Menéndez V, de Pedro N, Tormo JR, Almeida C, Lambert C, Genilloud O, Trougakos IP, Fokialakis N. Cercospora sp. as a source of anti-aging polyketides targeting 26S proteasome and scale-up production in submerged bioreactor. J Biotechnol., 2019, 301: 88-96. Abstract
Martínez KA, Lauritano C, Druka D, Romano G, Grohmann T, Jaspars M, Martín J, Díaz C, Cautain B, de la Cruz M, Ianora A, Reyes F. Amphidinol 22, a new cytotoxic and antifungal amphidinol from the dinoflagellate Amphidinium carterae. Mar. Drugs, 2019, 17: 385. Abstract
Díaz C, Pérez del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J. Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate. ACS Infectious Diseases., 2019, 5: 1317-1326. Abstract
Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez Martinez I, Tormo JR, Martín JM, Urbatzka R, Vicente FM, Lage OM. Bioactivities and Extract Dereplication of Actinomycetales isolated from Marine Sponges. Front Microbiol., 2019, 10: 727. Abstract
Pérez del Palacio J, Díaz-Navarro C, Martín-Blázquez A, González-Olmedo C, Vergara-Segura N, Algieri F, Rodriguez-Nogales A, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, Rodríguez-Cabez MA. Metabolomic analysis of Lavandula dentata L. and Lavandula stoechas L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool. Plant. Biosyst., 2019, 154:231-240. Abstract
Butassi E, Svetaz LA, Zhou S, Wolfender JL, G. Cortés JC, Ribas JC, Díaz-Navarro C, Pérez del Palacio J, Vicente F, Zacchino SA. The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera. Phytomedicine, 2019, 60: 152884. Abstract
Martín J, Reyes F, Vicente F, Gamboa-Angulo M, Escalante-Réndiz D, De la Rosa García S, Tapia-Tussell R. Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity. Int J. Environ. Res. Public Health, 2019, 16: 1913. Abstract
Khentoul H, Bensouici C, Reyes F, Albanese D, Sarri D, Mekkiou R, Benayache F, Seghiri R, Boumaza O. Chemical constituents and HRESI-MS analysis of an Algerian endemic plant-Verbascum atlanticum Batt.- extracts and their antioxidant activity. Nat. Prod. Res., 2019, 22: 1-5. Abstract
Guillen PO, Jaramillo KB, Jennings L, de la Cruz M, Cautain B, Reye Fs, Rodríguez J, Thomas OP. Halogenated tyrosine derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini. J. Nat. Prod., 2019, 82: 1354-1360. Abstract
Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P. Activation of secondary metabolite gene clusters in Streptomyces clavuligerus by the PimM regulator of Streptomyces natalensis. Front. Microbiol., 2019, 10: 580. Abstract
Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Caniferolide A, a macrolide from Streptomyces caniferus, attenuates neuroinflammation, oxidative stress, amyloid-beta and tau pathology in vitro. Mol. Pharm., 2019, 16: 1456-1466. Abstract
Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Diaz C, Cautain B, Vicente F, Genilloud O, Reyes F. Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive glycosylated 36-membered polyol macrolides from the marine-derived Streptomyces caniferus CA-271066. Org. Biomol. Chem., 2019, 17:2954-2971. Abstract
Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Gloria Blanco. Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. Mar. Drugs, 2019, 17 (2) : 114. Abstract
Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Les´nikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, and Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discover., 2019, 24: 398-413. Abstract
Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2019, 33: 66-73 Abstract
Castillo F., Mackenzie T.A., Cautain B. Immunofluorescence Analysis by Confocal Microscopy for Detecting Endogenous FOXO. Link W. (eds) FOXO Transcription Factors. Methods in Molecular Biology, 2019, 1890: 143-149. Abstract
Koagne RR, Annang F, de la Cruz M, Bitchagno GTM, Perez-Victoria I, Konga IS, Vicente F, Reyes F, Tane P. Antibacterial Activity of Flavans from Crinum distichum. Natural Product Communications 2018, 13 : 637-1638. Abstract
Genilloud O. Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm? Antibiotics, 2018, 7: 85. Abstract
Calabro K, Chalén BE, Genta-Jouve G, Jaramillo KB, Domínguez C, de la Cruz M, Cautain B, Reyes F, Thomas OP, Rodríguez J. Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica. J. Nat. Prod., 2018, 81, 2301-2305. Abstract
Rodríguez V, J. Martín, A. Sarmiento-Vizcaíno, M. de la Cruz, L. A. García, G. Blanco, Reyes F. Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169. Mar. Drugs, 2018, 16: 406. Full text
Ortiz-López FJ, Alcalde E, Sarmiento-Vizcaíno A, Díaz C, Cautain B, García, Blanco G, Reyes F. New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157. Mar. Drugs, 2018, 16: 371. Abstract
Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Streptocyclinones A and B ameliorate Alzheimer’s disease pathological processes in vitro. Neuropharmacology, 2018, 141: 283-295. Abstract
Solanki H, Angulo-Preckler C, Calabro K, Kaur N, Lasserre P, Cautain B, de la Cruz M, Reyes F, Avila C, Thomas OP. Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905). Tetrahedron Lett., 2018, 59: 3353-3356. Abstract
Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353. J. Nat. Prod., 2018, 81: 1687-1691. Abstract
Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Olano C, Salas JA, Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149. Appl Environ Microbiol 84:e01462-18. Abstract
Li F, Janussen D, Peifer C, Pérez-Victoria I, Tasdemir D, Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity. Mar. Drugs 2018, 16, 268. Abstract
Lage OM, Ramos MC, Calisto R, Almeida E, Vasconcelos V, Vicente F. Current Screening Methodologies in Drug Discovery for Selected Human Diseases. Marine Drugs. 2018; 16(8):279. Full article
Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo-Contreras E, Martín J, Machenzie T, Ruiz-Pérez L, González-Packanowska D, Genilloud O, Vicente F, Agyare C, Reyes F. Bioassay-guided isolation of four new antiprotozoal compounds from two Ghanaian mushrooms. Fitoterapia 2018 Jun, 127:341-348. Abstract
González-Menéndez V, Crespo G, De Pedro N, Diaz C, Martín J, Serrano R, Mackenzie TA, Justicia C, González-Tejero MR, Casares M, Vicente F, Reyes F, Tormo JR, Genilloud O. Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents. Nature.com, Scientific Reports, 2018, 8: 9729. Abstract
Almeida C, Silva Pereira C, González-Menéndez V, Bills G, Pascual J, Sánchez-Hidalgo M, Kehraus S, Genilloud O. Unveiling concealed functions of endosymbiotic bacteria harboured in the Ascomycota Stachylidium bicolor. Appl. Environ. Microbiol., 2018, DOI: 10.1128/AEM.00660-18. Abstract
Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O. Non-geminal aliphatic dihalogenation pattern in dichlorinated diaporthins from Hamigera fusca NRRL 35721. J. Nat. Prod., 2018, 81, 6, 1488–1492. Abstract
Sarmiento-Vizcaíno A, Espadas J, Martín J, Braña AF, Reyes F, García LA, Blanco G. Atmospheric precipitations, hailstone and rainwater, as a novel source of Streptomyces producing bioactive natural products. Front. Microbiol., 2018, 9:773. Abstract
Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Natural product Research, 2018, https://doi.org/10.1080/14786419.2018.1434636. Abstract
Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, Díaz-Navarro C, Pérez-Del Palacio J, García-Fernández M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla-Ortega E. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018 May 1;133:189-201. Abstract
Pachón-Ibáñez ME, Labrador-Herrera G, Cebrero-Cangueiro T, Díaz C, Smani Y, del Palacio JP, Rodríguez-Baño J, Pascual A, Pachón J and Conejo MC. Efficacy of Colistin and Its Combination with Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. Front. Microbiol 2018. 9:912. Abstract
Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N, Vallorani R, Diaz C, Pérez del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM. Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A, ACS Chem. Neurosci. 2018 DOI: 10.1021/acschemneuro.8b00060. Abstract
Ramos MC, Genilloud O, Reyes F, Vicente F. Drug Discovery from Natural Products for Pancreatic Cancer. Pancreatic Cancer Book. Intech, 2018. DOI: 10.5772/intechopen.76399 Abstract
Sánchez M, González I, Díaz C, Martínez G and Genilloud O. Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains. Front. Microbiol. 2018, 9:369. doi: 10.3389/fmicb.2018.00369. Abstract
Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2018, DOI:10.1080/14786419.2018.1434636. Abstract
Lauritano C, Martín J, de la Cruz M, Reyes F, Romano G, Ianora A. First identification of marine diatoms with anti-tuberculosis activity. Sci. Rep., 2018, 8:2284. Abstract
Sánchez L, Ladrón de Guevara D, Mañas MC, Alén F, Moreno RD, Díaz C, Perez del Palacio J, García M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla E, Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology (2018), doi: 10.1016/j.neuropharm.2018.01.033. Abstract
Pérez-Bonilla M, Oves-Costales D, de la Cruz M, Kokkini M, Martín J, Vicente F, Genilloud O and Reyes F. Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp. Mar. Drugs 2018, 16(3), 95; doi:10.3390/md16030095. Abstract
Castillo F, Mackenzie TA, Cautain B. Immunofluorescence analysis by confocal microscopy for detecting endogenous FOXO. Methods in Molecular Biology, DOI 10.1007/978-1.
Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA. Searching for glycosylated natural products in actinomycetes and identification of novel macrolactams and angucyclines. Front. Microbiol., 2018, 9:39. Abstract
Firsova D, Calabro K, Lasserre P, Reyes F, Thomas OP. Isoguanosine Derivatives from the Northeastern Atlantic Sponge Clathria (Microciona) strepsitoxa. Tetrahedron Lett., 2017, 58:4652-4654. Abstract
Genilloud O. Actinomycetes: still a source of novel antibiotics. Nat. Prod. Rep., 2017,34, 1203-1232, 10.1039/C7NP00026J. Abstract
Genilloud O, Industrial Culture Collections: Gateways from Microbial Diversity to Applications in Microbial Resources: From Functional Existence in Nature to Applications, Ed J. Wink, 2017, Academic Press 237-256.
Ilic J, Cosic J, Vrandecic K, Dugalic K, Pranjic A, Martin J. Influence of endophytic fungi isolated from symptomless weeds on cherry plants. Mycosphere 2017: 8, 18-30. Full article
Peláez F, de Pedro N, Tormo JR. Chapter 9 of the book: Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Toxicological Implications, in Natural Products Targeting Clinically Relevant Enzymes (eds P. B. Andrade, P. Valentão and D. M. Pereira), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2017, Germany. doi: 10.1002/9783527805921
Braña AF, Sarmiento-Vizcaíno A, Osset M, Pérez-Victoria I, Martín J, de Pedro N, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa. Mar. Drugs, 2017, 15:144. Abstract
Calabro K, Kalahroodi EL, Rodrigues D, Díaz C, Cruz M, Cautain B, Laville R, Reyes F, Pérez T, Soussi B, Thomas OP. Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866). Mar Drugs, Jun 15:199, doi: 10.3390/md15070199. Abstract
Pascual J, García-López M, González I, Genilloud O. Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers. International Journal of Systematic and Evolutionary Microbiology, Sept. 67(10), DOI:10.1099/ijsem.0.002227. Abstract
Martínez G, González-Menéndez V, Martín J, Reyes F, Genilloud O, Tormo JR. MASS Studio: A Novel Software Utility to Simplify LC-MS Analyses of Large Sets of Samples for Metabolomics. In: Rojas I., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science, vol 10208. Springer, Cham. Abstract
Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Correction for Bertoni-Mann et al., “Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum CF-295141, Isolated from Pinus sylvestris ”. Genome Announcements 2017, 5(43):e01116-17., DOI:10.1128/genomeA.01116-17. Abstract
Almeida C, Bills G, González-Menéndez V, Martin J, Tormo JR, Genilloud O. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04. Fermentation 2017, 3(3):45., DOI:10.3390/fermentation3030045. Full paper
Boulaiz H, Ramos MC, Griñán-Lisón C, García-Rubiño ME, Vicente F, Marchal JA, What’s new in the diagnosis of pancreatic cancer: a patent review (2011-present), Expert Opinion. Expert Opin Ther Pat. 2017, Sept 10: 1-16. Full paper
Gonzalez-Menendez V, Martin J, Siles JA, Gonzalez-Tejero MR, Reyes F, Platas G, Tormo JR, Genilloud O. Biodiversity and chemotaxonomy of Preussia isolates from the Iberian Peninsula. Mycol Progress 2017, Vol.16, 7:713 – 728. Full paper
Ramos MC, Boulaiz H, Griñan-Lison C, Marchal JA, Vicente F. What’s new in treatment of pancreatic cancer: a patent review (2010-2017). Expert Opin Ther Pat. 2017, Jul 12:1-16, Full paper
Serrano R, González V, Rodríguez L, Martín J, Tormo JR, Genilloud O. Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents. Front. Microbiol., 2017, 649, Full paper
Pérez-del Palacio J, Díaz C, Vergara N, Algieri F, Rodríguez-Nogales A, de Pedro N, Rodríguez-Cabezas ME, Genilloud O, Gálvez J, Vicente F. Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. Front. Pharmacol, 2017, Full paper
Sonnenschein EC, Stierhof M, Goralczyk S, Vabre FM, Pellissier L, Hanssen KE, de la Cruz M, Díaz C, de Witte P, Copmans D, Andersen JH, Hansen E, Kristoffersen V, Tormo JR, Ebel R, Milne BF, Deng H, Gram L, Jaspars M, Tabudravu JN. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron, 2017, Chemical Engineering Journal, 2017, 320: 151-159. Abstract
Vela-Soria F, Gallardo Torres ME, Ballesteros O, Diaz C, Perez J, Navalón A, Fernandez MF, Olea N. Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Cromatography A, 2017, 1487: 153-161. Abstract
Borges-Argáez R, Cáceres-Farfán M, De Pedro N, Cautain B, Pérez del Palacio P, Vicente F, Genilloud O, Melguizo A, Díaz C, Reyes F, El Aouad N, Sansores-Peraza P. Cytotoxic studies and in vitro effects oftrans -3,4,4’,5-Tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth. Polibotanica, 2017, 43: 165-175. Full paper
Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, De Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MJ, Vicente F, Genilloud O, Tormo JR, Reyes F. Hormonemate Derivatives from the Endophytic Fungus Dothiora sp. J. Nat. Prod., 2017, DOI: 10.1021/acs.jnatprod.6b00680. Full paper
Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina sp. Planta Med., 2017, 05: 366-491. Abstract
Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, De la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Branimycins B and C, Antibiotics Produced by the abyssal Actinobacterium Pseudonocardia carboxydivorans M-227. J. Nat. Prod., 2017, 80: 569-573. Abstract
De la Cruz M, González I, Parish C, Onishi R, Tormo JR, Martín J, Peláez F, Zink D, El Aouad N, Reyes F, Genilloud O, Vicente F. Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes. Front. Microbiol., 2017, 8:343. Fullpaper
Paytubi S, De la Cruz M, Tormo JR, Martín J, González I, González-Menéndez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C. Microbial Natural Products High-Throughput Screening Platform for the Discovery of Molecules with Antibiofilm Properties Against Salmonella. Front. Microbiol., 2017, 8: 326. Fullpaper
González A, Gálvez N, Martín J, Reyes F, Pérez-Victoria I, Dominguez-Vera JM. Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption. Food Chem., 2017, 228: 374-380. Abstract
Trabelsi I, Oves D, Manteca A, Genilloud O, Altalhi A, Nour M. Antimicrobial Activities of Some Actinomycetes Isolated from Different Rhizospheric Soils in Tunisia. Current Microbiology 2016, 73:220-227. Abstract
Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodríguez Quesada L, Machado L, Vicente F, Dallavalle S, Link W. Discovery of a Novel Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS ONE 2016, 11: e0167491. Abstract
Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Draft Genome Sequence of Phytopathogenic Fungus Fusarium fujikuroi CF-295141, Isolated from Pinus sylvestris. Genome Annoucements 2016, 4: e01163-16. Abstract
Lacret R, Pérez-Victoria I, Oves-Costales D, de la Cruz M, Domingo E, Martín J, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0170, a new napyradiomycin from Streptomyces sp. strain CA-271078. Mar. Drugs 2016, 14: 188. Abstract
Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina sp. Planta Med. 2016, 81(S01): S1-S381. Abstract
Stierhof M, Hansen KO, Sharma M, Feussner K, Subko K, Fernandez Díaz-Rullo F, Isaksson J, Pérez-Victoria I, Clarke D, Hansen E, Jaspars M, Tabudravu JN. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp. Tetrahedron 2016, 72: 6929-6934. Abstract
Angulo-Preckler C, Genta-Jouve G, Mahajan N, de la Cruz M, de Pedro N, Reyes F, Iken K, Avila C, Thomas OP. Gersemiols A-C and Eunicellol A, Diterpenoids from the Arctic Soft coral Gersemia fruticosa. J. Nat. Prod. 2016, 79: 1132-1136. Abstract
Pascual J, González I, Estévez M, Benito P, Trujillo ME, Genilloud O. Description of Kibdelosporangium banguiense sp. nov., a novel actinomycete isolated from soil of the forest of Pama, on the plateau of Bangui, Central African Republic. Antoine van Leeuwenhoek 2016, 109: 685-695. Abstract
Pascual J, García-López M, Bills GF, Genilloud O. Longimicrobium terrae gen. nov., sp. nov., a novel oligotrophic bacterium of the underrepresented phylum Gemmatimonadetes isolated through a system of miniaturized diffusion chambers. Int. J. Syst. Evol. Microbiol. 2016, 66: 1976-85. Abstract
García-Fontana B, Morale-Santana S, Díaz Navarro C, Rozas-Moreno P, Genilloud O, Vicente Pérez F, Pérez del Palacio J, Muñoz-Torres M. Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study. Talanta 2016, 148: 135-143. Abstract
Sekurova ON, Pérez-Victoria I, Martin J, Degnes KF, Sletta H, Reyes F, Zotchev SB, New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07, Molecules 2016, 21(9): 1131. Abstract
De Pedro N, Cautain B, Cantizani J, Rodriguez L, Vicente F, Tualsi R and Rao Koyyalamudi S. In vitro Neuroprotective Effects of Seven Natural products Against Rotenone-Induced Toxicity in a SH-SY5Y Neuroblastoma Cells Model for Parkinson’s Disease. Pharmacologia 2016, 7: 361-370. Full paper
Vela-Soria1 I, Jiménez-DíazC, Díaz J, Pérez LM, Iribarne-Durán L, Serrano-López JP, Arrebola1 MF, Fernández N, Olea. Determination of endocrine disrupting chemicals in human milk by dispersive liquid-liquid microextraction. Bioanalysis 2016, 17: 1777-91. Abstract
Algieri F, Rodriguez-Nogales A, Vezza T, Garrido-Mesa J, Garrido-Mesa N, Utrilla MP, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, del Mar Contreras M, Segura-Carretero A, Pérez-Palacio J, Diaz C, Vergara N, Vicente F, Rodriguez-Cabezas ME, Galvez J: Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L. J Ethnopharmacol 2016, 190: 142–158. Abstract
Annang F, Genilloud O, Vicente F. Contribution of Natural Products to Drug Discovery in Tropical Diseases. Chapter · July 2016, In book: Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, pp.75-104
Vicente F, Reyes F, Genilloud O. Fungal secondary metabolites as source of antifungal compounds. In Fungi: Applications and their Management Strategies. Sunil K. Deshmukh, J. K. Misra, Jalpa P. Tewari, Tamas Papp Eds., CRC Press, 2016. ISBN: 9781498724913, pp. 80-116 – Summary
Gonzalez-Menéndez V, Pérez-Bonilla M, Pérez-Victoria I, Martín J, Muñoz F, Reyes F, Tormo JR, Genilloud O. Multicomponent analysis of the differential induction of secondary metabolite profiles in fungal endophytes. Molecules 2016, 21(2): 234 – Full paper
Pérez del Palacio I, Díaz C, De la Cruz M, Annang F, Martín J, Pérez-Victoria I, González-Menéndez V, De Pedro N, Tormo JR, Algieri F, Rodriguez-Nogales A, Rodríguez-Cabezas ME, Reyes F, Genilloud O, Vicente F, Gálvez J. High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries. J. Biomol. Screen. 2016, 21(6): 567-78 – Abstract
Pérez-Victoria, Martín J, Reyes F. Combined LC/UV/MS and NMR strategies for the dereplication of marine natural products. Planta Med 2016, 82: 857–871 – Full paper
De Pedro N, Cantizani J, Ortiz-López FJ, González-Menéndez V, Cautain B, Rodríguez L, Bills GF, Reyes F, Genilloud O and Vicente F. Protective Effects of Isolecanoric Acid on Neurodegenerative Diseases. Neuropharmacology, 2016, 101: 538-548 – Abstract
Pérez-Moreno, Cantizani J, Sánchez-Carrasco P, Ruiz-Pérez LM, Martín J, El Aouad N, Pérez-Victoria I, Tormo JR, González V, González I, De Pedro N, Reyes F, Genilloud O, Vicente F, González-Pacanowska D. Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products. PLoS ONE 2016, 11(1): e0145812 – Abstract
Jaspars, De Pascale D, Andersen JH, Reyes F, Crawford AD, Iannora A. The Marine Biodiscovery Pipeline and Ocean Medicines of Tomorrow. J. Mar. Biol. Assoc. U.K. 2016, 96: 151-158 – Full paper
Pascual J, Blanco S, García-López M, García-Salamanca A, Bursakov SA, Genilloud O, Bills OF, Ramos JL, van Dillewijn P. Assessing Bacterial Diversity in the Rhizosphere of Thymus zygis Growing in the Sierra Nevada National Park (Spain) through Culture-Dependent and Independent Approaches. PLoS ONE 2016, 11: e0146558 – Abstract
Parra Millán R, Jiménez Mejías ME, Sánchez Encinales V, Ayerbe Algaba R, Gutiérrez Valencia A, Pachón Ibáñez ME, Díaz C, Pérez del Palacio J, López Cortés LF, Pachón J, Smani Y. Efficacy of Lysophosphatidylcholine in Combination with Antimicrobial Agents against Acinetobacter baumannii in Experimental Murine Peritoneal Sepsis and Pneumonia Models. Antimicrob Agents Chemother 2016, 60: 4464–4470.2 – Abstract
Fernández-Cruz ML, Martín-Cabrejas I, Pérez-del Palacio J, Gaya P, Díaz-Navarro C, Navas JM, Medina M, Arqués JL. In vitro toxicity of reuterin, a potential food biopreservative. Food Chem Toxicol 2016, 96: 155–159.5 – Abstract
Ríos Peces S, Díaz Navarro C, Márquez López C, Caba O, Jiménez-Luna C, Melguizo C, Prados JC, Genilloud O, Vicente Pérez F, Pérez del Palacio J. Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma. J Biomol Screen 2016: 1087057116671490.8 – Abstract
N’Ait Ousidi A, Ait Itto MY, Auhmani A, Barakate M, Riahi A, Ben El Ayouchia H, Anane H, El Aouad N, De La Cruz M, Díaz C, Vicente F. Synthesis, theoretical and biological studies of some novel Monoterpenic thiazolidin-4-ones. IOSR Journal of Applied Chemistry. Volume 9, Issue 11 Ver. II 2016, 52-61 – Full paper
Painter RE, Adam GC, Arocho M, DiNunzio E, Donald RG, Dorso K, Genilloud O, Gill C, Goetz M, Hairston NN,Murgolo N, Nare B, Olsen D.B, Powles M, Racine F, Su J, Vicente F, Wisniewski D, Xiao L, Hammond M, Young K. Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin. Chem Biol. 2015, 22(10): 1362-73 – Abstract
Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, De Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA. Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010). Antimicrob Agents Chemother. 2015, 59 (9): 5145-53 – Full paper
Muñoz-Sáeza E, De Munck Garcíab S, Arahuetes Porterob RM, Vicente F, Ortiz-López FJ, Cantizani J, Gómez Miguel B. Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). Neuroscience Letters 2015, 593: 83–89 – Abstract
Molina-Santiago C, Udaondo Z, Daddaoua A, Roca A, Martín J, Pérez-Victoria I, Reyes F, Ramos JL. Efflux pump deficient mutants as a platform to search for microbes that produce antibiotics. Microb. Biotechnol. 2015, 8: 716-725 – Abstract
Tormo JR, Oves D, Lacret D, Moreno C, DeLa Cruz M, Díaz C, González I, Martín J, Pérez-Victoria, Vicente F, Reyes F, Genilloud O. Marine natural products drug discovery from actinomycetes at Fundacion MEDINA. Planta Medica 2015, 81:11 – Abstract
Cautain B, De Pedro N, Schulz C, Pascual J, Sousa TS, Martin J, Pérez-Victoria I, Asensio F, González I, Bills G.F, Reyes F, Genilloud O, Vicente F Identification of the lipodepsipeptide MDN-0066, a novel inhibitor of VHL/HIF pathway produced by a new Pseudomonas species. PLOS ONE 2015, 10(5): e0125221 – Abstract
Figueroa L, Jiménez C, Rodríguez J, Areche C, Chávez R, Heríquez M, De la Cruz M, Díaz C, Segade Y, Vaca I. 3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus. J. Nat Prod. 2015, 78 (4): 919–923 – Abstract
Ortiz-López FJ, Monteiro MC, González-Menéndez V, Tormo JR, Genilloud O, Bills GF, Vicente F, Zhang C, Roemer T, Singh SB, Reyes F. Cyclic Colisporifungin and Linear Cavinafungins, three Antifungal Lipopeptides Isolated from Colispora cavincola. J. Nat. Prod. 2015, 78 (3): 468–475 – Abstract
Pascual J, García-López M, Bills GF, Genilloud O Pseudomonas granadensis sp. nov., a new bacterial species isolated from the Tejeda, Almijara and Alhama Natural Park, Granada, Spain. Int. J. Syst. Evol. Microbiol. 2015, 65: 625-632 – Asbtract
Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. ACS Infect. Dis. 2015, 1: 59-72 – Full Paper
Cautain B, De Pedro N, Reyes F, Link W Image-Based Identification of Nuclear Export Inhibitors from Natural Products. Methods Mol. Biol. 2015, 1270: 307-319 – Abstract
Lacret R, Oves-Costales D, Gómez C, Díaz C, de la Cruz M, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis. Mar. Drugs 2015, 13: 128-140 – Full Paper
Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo J R, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez L M, Navarro M, Gamarro F, González-Pacanowska D High throughput screening platform for Natural Product-based drug discovery against three Neglected Tropical Diseases: human African trypanosomiasis, leishmaniasis and Chagas disease. J. Biomol. Screen. 2015, 20: 82-91 – Abstract
Perez J, Díaz C, Asensio F, Palafox A, Genilloud O, Vicente F A Novel In Vitro Approach for Simultaneous Evaluation of CYP3A4 Inhibition and Kinetic Aqueous Solubility. J. Biomol. Screen. 2015, 20(2): 254-264 – Abstract
Cautain B, Hill R, de Pedro N, Link W Components and regulation of nuclear transport processes. FEBS J. 2015, 282(3): 445-462 – Full Paper
Castillo Correa FJ, De Pedro N, Rodriguez Quesada L, Oves Costales D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014; 50 supplement: 6-24
Cantizani J, Ortiz J, Ravipati AS, Rodrigueza L, Cautain B, Zhang L, Reddy N, Nath CE, Vicente F, De Pedro N., and Koyyalamudi SR Screening for Natural Inhibitors in Chinese medicinal plants against Glycogen Synthase Kinase 3β (GSK-3β) Pharmacologia 2014, 5: 205-214
Ondeyka JG, Smith SK, Zink DL, Vicente F, Basilio A, Bills GF, Polishook JD, Garlisi C, Mcguinness D, Smith E, Qiu H, Gill CJ, Donald RGK, Phillips JW, Goetz MA, Singh SB Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin. J. Antibiot 2014, 67(7): 527-531
Genilloud O The re-emerging role of microbial natural products in antibiotic discovery. Antoine van Leeuwenhoek 2014, 106: 173-188
Martín-Rodríguez A J, Reyes F, Martín J, Pérez-Yépez J, León-Barrios M, Couttolenc A, Espinoza C, Trigos Á, Martín V, M. Norte, Fernández J J Inhibition of Bacterial Quorum Sensing by Extracts from Aquatic Fungi: First Report from Marine Endophytes. Mar. Drugs 2014, 12(11): 5503-5526 – Full Paper
Guimarães L A, Jimenez P C, Sousa T da S, Freitas H P S, Rocha D D, Wilke D V, Martín J, Reyes F, Pessoa O D L, Costa-Lotufo L V Chromomycin A2 induces autophagy in melanoma cells Mar. Drugs 2014, 12(12): 5839-55 – Full Paper
Martín J, Crespo G, González-Menéndez V, Pérez-Moreno G, Sánchez-Carrasco P, Pérez-Victoria I, Ruiz-Pérez L M, González-Packanowska D, Vicente F, Genilloud O, Bills G F, Reyes F MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii. J. Nat. Prod. 2014, 77(9): 2118-23. – Abstract
Pascual J, García-López M, Carmona C, da S. Sousa T, de Pedro N, Cautain B, Martín J, Vicente F, Reyes F, F. Bills G, Genilloud O Pseudomonas soli sp. nov., a novel producer of xantholysin congeners. Syst. Appl. Microbiol 2014, 37(6): 412-6 – Abstract
González-Menéndez V, Asensio F, Moreno C, de Pedro N, Monteiro MC, de la Cruz M, Vicente F, Bills G, Reyes F, Genilloud O & Tormo JR Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity. Micology 2014, 5(3): 179-191 – Full Paper
Montiel R, Martín-Cabrejas I, Langa S, El Aouad N, Arqués J L, Reyes F, Medina M. Antimicrobial activity of reuterin produced by Lactobacillus reuteri on Listeria monocytogenes in cold-smoked salmon.Food Microbiol. 2014, 44: 1-5 – Abstract
Almeida C, El Aouad N, Martín J, Pérez-Victoria I, González-Menéndez V, Platas G, de la Cruz M, Monteiro MC, de Pedro N, Bills GF, Vicente F, Genilloud O, and Reyes F Graminin B, a furanone from the fungus Paraconiothyrium sp. J Antibiot 2014, 67: 421-423 – Abstract
Singh S, Ondeyka J, Buevich A, Williamson R, Zink D, Polishook J, Occi J, Vicente F, Basilio A, Bills G, Donald R, Phillips J, Goetz M Isolation, Structure Elucidation and Biological Activity of Altersolanol P using Staphylococcus aureus Fitness Test Based Genome-wide Screening. J. Nat. Prod. 2014, 77(3): 497-502
Siles JA, Pascual J, González-Menéndez V, Sampedro I, García-Romera I, Bills GF Short-term dynamics of culturable bacteria in a soil amended with biotransformed dry olive residue. Syst Appl Microbiol 2014, 37(2): 113-20
Siles JA, González-Menéndez V, Platas G, Sampedro I, García-Romera I, Bills GF Effects of Dry Olive Residue Transformed by Coriolopsis floccosa (Polyporaceae) on the Distribution and Dynamic of a Culturable Fungal Soil Community. Microb Ecol 2014, 67(3): 648-58
Hill R, Cautain B, de Pedro N & Link W Targeting Nucleocytoplasmic Transport in Cancer Therapy. Oncotarget 2014, 5(1): 11-28 – Abstract
Castelli MV, Butassi C, Monteiro MC, Svetaz LA, Vicente F, Zacchino SA Novel antifungal agents: a patent review (2011 – 2014), Exp Op Ther Pat: 24 (3): 1-16 – Abstract
Cautain B, de Pedro N, Murillo Garzón V, Muñoz de Escalona M, González Menéndez C, Tormo JR, Martin J, El Aouad N, Reyes F, Asensio F, Genilloud O, Vicente F and Link W A cell-based strategy using high-content imaging for the discovery of novel nuclear export inhibitors from natural products. J Biomol Screen 2014, 19: 57-65
Chen L, Yue Q, Zhang X, Xiang M, Wang C, Li S, Che Y, Ortiz-López FJ, Bills GF, Liu X and An Z Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC Genomics 2013, 14: 339 – Abstract
Gracia AP, Bondoso J, Gaspar H, Xavier JR, Monteiro MC, de la Cruz M, Oves-Costales D, Vicente F, Lage OM Antimicrobial Activity of Heterotrophic Bacterial, Communities from the Marine Sponge Erylus discophorus (Astrophorida, Geodiidae). Plos One 2013, 8: 11, e78992 – Abstract
Cautain B, de Pedro N, Muñoz de Escalona M, Tormo JR, Genilloud O, Vicente F HCS Strategy Targeting Dysregulation Of The VHL/HIF Pathway For Drug Discovery. Adv Biosci and Biotechnol 2013, 4: 398-405 – Abstract
Singh SB, Zhang C, Zink DL, Herath K, Ondeyka J, Masurekar P, Jayasuriya H, Goetz MA, Tormo JR, Vicente F, Martín J, González I, Genilloud O Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening. J Antibiot 2013, 66: 599-607 – Abstract
Audoin C, Bonhomme D, Ivanisevic J, de la Cruz M, Cautain B, Monteiro MC, Reyes F, Rios L, Perez T and Thomas OP Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi. Mar Drugs 2013, 11: 1477-1489 – Abstract
Martín MJ, Coello L, Fernández R, Reyes F, Rodríguez A, Murcia C, Garranzo M, Mateo C, Sánchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, and Cuevas C Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds. J Am Chem Soc 2013, 135: 10164-10171 – Abstract
Palomo S, González I, Martín J, de la Cruz M, Vicente F, Reyes F, Tormo JR, Anderson M, Hill RT, Genilloud O Sponge-derived Kocuria and Micrococcus spp. as new sources of thiazolylpeptide antibiotics. Mar Drugs 2013, 11: 1071-1086 – Abstract
Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de la Cruz M, Monteiro MC, Melguizo A, Jiménez E, Vicente F Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pacific J Trop Med 2013, 6(9): 673-81 – Abstract
Sheo B. Singh John Ondeyka, Harris G, Herath K, Zink D, Vicente F, Bills G, Collado J, Platas G, González de Val A, Martin J, Reyes F, Wang H, Nielsen Kahn J, Galuska S, Giacobbe R, Abruzzo G, Roemer T, Xu D. Isolation, structure and biological activity of a cyclic lipodepsipeptide phaeofungin from a Phaeosphaeria sp. using the genome-wide Candida albicans Fitness Test. J Nat Prod 2013, 76: 334-345 – Abstract
García E, Alonso A, Platas G and Sacristán S. The endophytic mycobiota of Arabidopsis thaliana. Fungal divers 2013, 60: 71-89 – Abstract
de Pedro N, Cautain B, Melguizo A, Vicente F, Genilloud O, Peláez F, Tormo JR Mitochondrial complex I inhibitors, acetogenins, induce 5 HepG2 cell death through the induction of the complete 6 apoptotic mitochondrial pathway. J Bioenerg Biomembr 2013, 45: 153-164 – Abstract
de Pedro Montejo N, Cautain B, Melguizo A, Cortes D, Vicente F, Genilloud O, Tormo JR, Peláez F Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I. J Bioenerg Biomembr 20013, 45(1-2): 145-152 – Abstract
Martin J, da S Sousa T, Crespo G, Palomo S, Gonzalez I, Tormo JR, de la Cruz M, Anderson M, Hill RT, Vicente F, Genilloud O, Reyes F Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris. Mar Drugs 2013, 11: 387-98 – Abstract
Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de Pedro N, Melguizo A, Cantizani J, Asensio F, Vicente F Anti-proliferative activities of selected Chinese medicinal herbs against human cancer cell lines. Phytopharmacology 2013, 4(2): 206-219 – Abstract
Baral HO, Galán R, Platas G & Tena R Phaeohelotium undulatum comb. nov. and Phaeoh. succineoguttulatum sp. nov., two segregates of the Discinella terrestris aggregate found under Eucalyptus in Spain: taxonomy, molecular biology, ecology and distribution. Mycosystema 2013, 32(3): 386-428 – Abstract
Pérez J, Díaz C, Salado IG, Pérez DI, Peláez F, Genilloud O, Vicente F Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays. Adv Biosci Biotechnol 2013, 4: 628-639 – Abstract
Singh SB, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, de la Cruz M, Martín J , Vicente F, Genilloud O, Donald RGK, Phillips JW Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities. Bioorg Med Chem letters 2012, 22: 7127-7130 – Abstract
Fernández-Acero T, Rodríguez-Escudero I, Vicente F, Monteiro MC, Tormo JR, Cantizani J, Molina M, Cid VJ A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors. J Biomol Screening 2012, 17(8): 1018-1029 – Abstract
Vicente MF, Bills G, Reyes F, Genilloud O Fundación MEDINA – Investigación en Terapias Innovadoras a partir de Productos Naturales aislados de Microorganismos. Especial Microbiología Industrial y Biotecnología Microbiana. Actualidad SEM 2012, 53: 32-35 – Article
Kai M, González I, Genilloud O, Singh SB, Svatoš A Direct mass spectrometric screening of antibiotics from bacterial surfaces using liquid extraction surface analysis. Rapid Commun. Mass Spectrom. 2012, 26(20): 2477-2482 – Abstract
Genilloud O Current Challenges in the Discovery of Novel Antibacterials from Microbial Natural Products. Recent Pat Antiinfect Drug Discov. 2012, 7(3): 189-204(16) – Abstract
Bills GF, Dombrowski AW and Goetz MA The “FERMEX” method for metabolite-enriched fungal extracts. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.). Meth Mol Biol 2012, 944(5): 79-96 – Abstract
Bills GF, González-Menéndez V, Martin J, Platas G, Fournier J, Peršoh D and Stadler M. Hypoxylon pulicicidumsp. nov. (Ascomycota, Xylariales), a Pantropical Insecticide-Producing Endophyte. PLOS One 2012, 7: e46687 – Abstract
Bills GF, González-Menéndez V and Platas G Kabatiella bupleuri sp. nov. (Dothideales), a pleomorphic epiphyte and endophyte of the Mediterranean plant, Bupleurum gibraltarium (Apiaceae). Mycologia 2012, 104: 962-973 – Abstract
Cueva C, Garcia Ruiz A, González-Rompinelli Bartolomé EB, Martín-Álvarez PJ, Salazar O, Vicente MF, Bills G and Moreno-Arribas V Degradation of biogenic amines by vineyard ecosystem fungi. Potential use in winemaking. J Appl Microbiol 2012, 112: 672-682 – Abstract
De la Cruz M, Martín J, González-Menéndez V, Pérez-Victoria I, Moreno C, Tormo JR, El Aouad N, Guarro J, Vicente F, Reyes F and Bills GF Chemical and physical modulation of antibiotic activity in Emericella species. Chem Biodiv 2012, 9: 1095-1113 – Abstract
El Aouad N, Pérez-Moreno G, Sánchez P, Cantizani J, Ortiz-López FJ, Martín J, González-Menéndez V, Ruiz-Pérez LM, González-Pacanowska D, Vicente F, Bills G and Reyes F Lasionectrin, a Naphthopyrone from a Lasionectria sp. J Nat Prod 2012, 75: 1228-1230 – Abstract
Genilloud O and Vicente F Novel approaches to exploit natural products from microbial resources. InDrug Discovery from Natural Products, Eds. O. Genilloud and F. Vicente, RSC series. 2012, 11: 221-248 – Book
Genilloud O Genus Micromonospora. In Bergey’s Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012 p. vol 5 B: 1039-1057 – Book
Genilloud O Suborder XI. Micromonosporineae and The family Micromonosporaceae. In Bergey’s Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012, vol 5 B: 1035-1038 – Book
Herath K, Jayasuriya H, Zink DL, Sigmund J, Vicente F, de la Cruz M, Basilio A, Bills GF, Polishook JD,DonaldR, Phillips J, Goetz M and Singh SB Isolation, structure elucidation and antibacterial activity of methiosetin, a new tetramic acid from a tropical sooty mold (Capnodium sp.). J Nat Prod 2012, 75: 420–424 – Abstract
Monteiro MC, de la Cruz M, Cantizani J, Moreno C, Tormo JR, Mellado E, de Lucas JR, Asensio F, Valiante V, Brakhage AA, Latgé J-P, Genilloud O and Vicente F A New Approach to Drug Discovery: High-Throughput Screening of Microbial Natural Extracts against Aspergillus fumigatus Using Resazurin. J Biomol Screen 2012, 17: 542-549 – Abstract
Pérez-Victoria I, Martín J, González-Menéndez V, de Pedro N, El Aouad N, Ortiz-López FJ, Tormo JR, Platas G, Vicente F, Bills GF, Genilloud O, Goetz MA and Reyes F Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica. J Nat Prod 2012, 75: 1210-1214 – Abstract
Sánchez-Hidalgo M, Pascual J, de la Cruz M, Martín J, Kath GS, Sigmund JM, Masurekar P, Vicente F, Genilloud O and Bills GF Prescreening bacteria colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system. Antonie van Leeuwenhoek 2012, 102: 361-374 – Abstract
Sánchez Márquez S, Bills GF , Herrero N and Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecol 2012, 5: 289–297 – Abstract
Tormo, JR, Asensio, FJ and Bills (GF) Manipulating filamentous fungus chemical phenotypes by growth in nutritional arrays. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.), Met Mol Biol 2012, vol. 944, 4: 59-78 – Abstract
Oves-Costales D and Challis GL Mining microbial genomes for metabolic products of cryptic pathways. InDrug Discovery from Natural Products, Eds. Genilloud O and Vicente F, RSC series 2012, 8: 140-158 – Abstract
El Aouad N, Monteiro MC, Pérez-Moreno G, Cantizani J, Moreno C, Martín J, González I, Vicente F, Genilloud O, González-Packanowska D, Tormo JR, Reyes F. A new natural Pepstatin from Kitasatospora sp. (Actinomycetales) Planta Medica. 2011, 77: 1345. Abstract
Ferrer M, Guazzaroni ME, Richter M, García-Salamanca A, Yarza P, Suárez-Suárez A, Solano J, Alcaide M, van Dillewijn P, Molina-Henares MA, López-Cortés N, Al-Ramahi Y, Guerrero C, Acosta A, de Eugenio LI, Martínez V, Marques S, Rojo F, Santero E, Genilloud O, Pérez-Pérez J, Rosselló-Móra R, Ramos JL Taxonomic and Functional Metagenomic Profiling of the Microbial Community in the Anoxic Sediment of a Sub-saline Shallow Lake (Laguna de Carrizo, Central Spain). Microb Ecol 2011, 62: 824-37 – Abstract
Cueva C, Moreno-Arribas V, Bartolomé B, Salazar O, Vicente MF & Bills GF Antibiosis of vineyard ecosystem fungi against food-borne microorganisms. Res Microbiol 2011, 162: 1043–1051 – Abstract
Torres MS, Tadych M, White JF Jr. & Bills GF Dilution-to-extinction cultivation of endophytic fungi and isolation and detection of grass endophytic fungi in different plant parts, Isolation and identification of fungal endophytes. Pgs. 13-18, 153-164. In: Prospects and Applications for Plant-Associated Microbes. A Laboratory Manual, Part B: Fungi. Editors Pirttilä AM & Sorvari S. BioBien Innovations 2011, Paimio, Finland
Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho Santiago Castanys L, Gamarro F, Morales JC, Pérez-Victoria JM, Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry. Bioenergetics 2011, 1808: 717–726 – Abstract
Sánchez Márquez S, Bills GF & Zabalgogeazcoa I Fungal species diversity in juvenile and adult leaves of Eucalyptus globulus from plantations affected by Mycosphaerella leaf disease. Ann Appl Biol 2011, 158: 177-187 – Article
Campos-Salinas J, Cabello-Donayre M, García-Hernández R, Pérez-Victoria I, Castanys S, Gamarro F and Pérez-Victoria JM A new ATP binding cassette protein is involved in intracellular haem trafficking in Leishmania. Molecular Microbiology 2011, 79(6): 1430-44- Abstract
Genilloud O, González I, Salazar O, Martín J, Tormo JR, Vicente F Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol, 38: 375–389 – Abstract
Roemer T, Xu D, Singh SB, Parish CA, Harris G, Wang H, Davies JE and Bills GF Confronting the Challenges of Natural Product-Based Antifungal Discovery. Chem Biol 2011, 18: 148-164 – Abstract
Xu D, Ondeyka J, Harris GH, Zink D, Nielsen Kahn J, Wang H, Bills G, Platas G, Wang W, Szewczak AA, Liberator P, Roemer T, and Singh SB Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test. J Nat Prod 2011, 74 (8): 1721-1730 – Abstract
Gabriel Moreno, Maria-Natividad Blanco, Julia Checa, Gonzalo Platas, Fernando Peláez Taxonomic and phylogenetic revision of three rare irpicoid species within the Meruliaceae. Mycol Progress 2011, 10: 481-491 – Abstract
Peláez F, Collado J, Platas G, Overy DP, Martín J, Vicente F, González del Val A, Basilio A, de la Cruz M, Tormo JR, Fillola A, Arenal F, Villareal M, Rubio V, Baral HO, Galán R and Bills GF The phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensis. Mycology 2011, 2: 1–17 – Abstract
Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, Lee S, Skwish S, de la Cruz M, Martín J, Vicente F, Genilloud O, Lu J, Painter RE, Young K, Overbye K, Donald RGK, and Singh SB Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus. Chem Biol 2011, 18: 955–965 – Abstract
Sánchez Márquez S, Bills GF, Herrero N, Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecology 2011 , 5(3): 289–297 – Abstract
Tijerino A, Cardoza RE, Moraga J, Malmierca MG, Vicente F, Aleu J, Collado IG, Gutiérrez S, Monte E, Hermosa R Overexpression of the trichodiene synthase gene tri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. Fungal Genet Biol 2011, 48: 285–296 – Abstract
El Aouad N, Ortiz-Lopez J, Martín J, Tormo JR, Goetz M and Genilloud O. New semi –automated method for the creation of a microbial fraction collection developed at Fundación MEDINA. Planta Medica 2010, 76: 1319 – Abstract
Ayers S, Zink DL, Mohn K, Powell JS, Brown CM, Bills G, Grund A, Thompson D and Singh SB Anthelmintic constituents of Clonostachys candelabrum. J Antibiot, 2010, 63: 119-122 – Abstract
Cueva C, Victoria Moreno-Arribas M, Martín-Alvarez PJ, Bills G, Vicente F, Basilio A, Lopez Rivas C, Requena T, Rodriguez JM and Bartolome B Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria. Res Microbiol 2010, 161: 372-382 – Abstract
Duetz W, Chase M and Bills G Miniaturization of fermentations. In Manual of Industrial Microbiology and Biotechnology, 3rd ed eds. Demain A, Davies J and Baltz R. pp.99-116. Washington, DC 2010: ASM Press – Book
Goetz MA, Zhang C, Zink DL, Arocho M, Vicente F, Bills GF, Polishook J, Dorso K, Onishi R, Gill C, Hickey E, Lee S, Ball R, Skwish S, Donald RGK, Phillips JW and Singh SB Coelomycin, a highly substituted 2,6-dioxo-pyrazine fungal metabolite antibacterial agent discovered by Staphylococcus aureus fitness test profiling. J Antibiot 2010, 63: 512-518 – Abstract
Márquez SS, Bills GF, Acuna LD and Zabalgogeazcoa I Endophytic mycobiota of leaves and roots of the grass Holcus lanatus. Fungal Diversity 2010, 41: 115-123 – Abstract
Peterson SW, Jurjevic Z, Bills GF, Stchigel AM, Guarro J and Vega FE Genus Hamigera, six new species and multilocus DNA sequence based phylogeny. Mycologia 2010, 102: 847-864 – Abstract
Bills G, Overy DP, Genilloud O and Peláez F Contributions of pharmaceutical antibiotic and secondary metabolite discovery to the understanding of microbial defense and antagonism. In Defensive Mutualism in Microbial Symbiosis eds. White JF and Torres MS. pp.257-297 Boca Raton, USA 2010: CRC Press – Book
Bills GF, Martín J, Collado J, Platas G, Overy D, Tormo JR, Vicente F, Verkleij G and Crous P Measuring the distribution and diversity of antibiosis and secondary metabolites in the filamentous fungi. Society of Industrial Microbiology News 2009, 59: 133-147 – Abstract
Bills GF, Platas G, Overy D, Collado J, Fillola A, Jiménez MR, Martín J, Val AGd, Vicente F, Tormo JR, Peláez F, Calati K, Harris G, Parish C, Xu D and Roemer T Discovery of the parnafungins, antifungal metabolites that inhibit mRNA poly-adenylation, from the Fusarium larvarum complex and other hypocrealean fungi. Mycologia 2009, 101: 445-469 – Abstract
Blanco MN, Moreno G, Checa J, Platas G and Peláez F Taxonomic and phylogenetic revision of Coniophora arachnoidea, C. opuntiae, and C. prasinoides. Mycotaxon 2009, 108: 467-477 – Abstract
Donald RGK, Skwish S, Forsyth RA, Anderson JW, Zhong T, Burns C, Lee S, Meng X, LoCastro L, Jarantow LW, Martin J, Lee SH, Taylor I, Robbins D, Malone C, Wang LS, Zamudio CS, Youngman PJ and Phillips JW AStaphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds. Chem Biol 2009, 16: 826-836 – Abstract
Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu DM, Roemer T and Singh SB (2009) Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp. Bioorg Med Chem 2009, 17: 1361-1369 – Abstract
Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, Platas G, Collado J, González A, de la Cruz M, Martin J, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Jiang B, Xu DM, Roemer T and Singh SB Isolation, structure elucidation, and biological activity of virgineone from Lachnum virgineum using the genome-wide Candida albicans fitness fest. J Nat Prod 2009, 72: 136-141
Overy D, Calati K, Kahn JN, Hsu M-J, Martin J, Collado J, Roemer T, Harris G and Parish CA Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products. Bioorg Med Chem Lett 2009, 19: 1224-1227 – Abstract
Parish CA, de la Cruz M, Smith SK, Zink D, Baxter J, Tucker-Samaras S, Collado J, Platas G, Bills G, Díez MT, Vicente F, Peláez F and Wilson K Antisense-guided isolation and structure elucidation of pannomycin, a substituted cis-decalin from Geomyces pannorum. J Nat Prod 2009, 72: 59-62 – Abstract
Platas G, González V, Collado J, Martín J, Montes C and Peláez F Ascription of poorly defined taxa to taxonomic entities using molecular phylogenies: a case study on Nodulisporium sp producers of nodulisporic acid. Mycotaxon 2009, 109: 443-460 – Abstract
Rojas JL, Martín J, Tormo JR, Vicente F, Brunati M, Ciciliato I, Losi D, Trappen SV, Mergaert J, Swings J, Marinelli F and Genilloud O Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites. Marine Genomics 2009, 2: 33-41 – Abstract
Singh SB, Jayasuriya H, Zink D, Basilio A, Vicente F, Collado J, Bills G, Lee Goldman M, Motyl M, Huber J, Dezeny G & Byrne K Discovery and antibacterial activity of glabramycin A-C from Neosartorya glabra by an antisense strategy. J Antibiot, 2009, 62: 265-269 – Abstract
Singh SB, Genilloud O and Peláez F NP structural diversity II – Secondary metabolite sources, evolution and selected molecular structures: Terrestrial micro-organisms – bacteria. In Comprehensive Natural Products Chemistry II eds. Moore, B and CrewsP., 2009, 109-140. UK: Elsevier – Book
Singh SB, Zink DL, Dorso K, Motyl M, Salazar O, Basilio A, Vicente F, Byrne KM, Ha S and Genilloud O Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered fromStreptomyces lucensis MA7349 using an antisense strategy. J Nat Prod 2009, 72: 345-352 – Abstract
Vicente F, Basilio A, Platas G, Collado J, Bills GF, González del Val A, Martín J, Tormo JR, Harris GH, Zink DL, Justice M, Kahn JN and Peláez F Distribution of the antifungal agents sordarins across filamentous fungi. Mycol Res 2009, 113: 754-770 – Abstract
Zhang C, Ondeyka JG, Zink DL, Basilio A, Vicente F, Salazar O, Genilloud O, Dorso K, Motyl M, Byrne K and Singh SB Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4. J Antibiot 2009, 62: 55-61 – Abstract
Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy. Bioorg Med Chem 2009, 17: 2162-2166 – Abstract
Ayers S, Zink DL, Powell JS, Brown CM, Grund A, Bills GF, Platas G, Thompson D and Singh SB Noreupenifeldin, a tropolone from an unidentified ascomycete. J Nat Prod 2008, 71: 457-459 – Abstract
Bills GF, Platas G, Fillola A, Jiménez MR, Collado J, Vicente F, Martín J, González A, Bur-Zimmermann J, Tormo JR and Peláez F Enhancement of antibiotic and secondary metabolite detection from filamentous fungi by growth on nutritional arrays. J Appl Microbiol 2008, 104: 1644-1658 – Abstract
Jiang B, Xu DM, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu WQ, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Peláez F, Díez MT, Kauffman S, Becker J, Harris G, Liberator P and Roemer T PAP inhibitor with in vivo efficacy identified byCandida albicans genetic profiling of natural products. Chem Biol 2008, 15: 363-374 – Abstract
Moreno G, Platas G, Peláez F, Bernedo M, Vargas A, Daza A, Santamaria C, Camacho M, de la Osa LR and Manjon JL Molecular phylogenetic analysis shows that Amanita ponderosa and A. curtipes are distinct species. Mycol Prog 2008, 7: 41-47 – Abstract
Ortega A, Moreno G, Platas G and Peláez F A new Armillaria mellea variant from tops of coastal sand dunes in southern Spain. Mycotaxon2008, 104: 349–364 – Abstract
Parish CA, Smith SK, Calati K, Zink D, Wilson K, Roemer T, Jiang B, Xu DM, Bills G, Platas G, Peláez F, Díez MT, Tsou N, McKeown AE, Ball RG, Powles MA, Yeung L, Liberator P and Harris G Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J Am Chem Soc 2008, 130: 7060-7066 – Abstract
Peláez F, González V, Platas G, Sánchez-Ballesteros J and Rubio V Molecular phylogenetic studies within the Xylariaceae based on ribosomal DNA sequences. Fungal Divers 2008, 31: 111-134 – Abstract
Rincón A, Arenal F, González I, Manrique E, Lucas MM Pueyo JJ Diversity of rhizobial bacteria isolated from nodules of the gypsophyte Ononis tridentata L. growing in Spanish soils. Microb Ecol 2008, 56: 223-233 Abstract
Rossman AY, Farr DF, Platas G and Newcombe G Hydropisphaera fungicola Rossman, Farr & Newcombe sp. nov. Fungal Planet 2008, 24 – Article
Ruibal C, Platas G and Bills GF High diversity and morphological convergence among melanised fungi from rock formations in the Central Mountain System of Spain. Persoonia 2008, 21: 93-110 – Article
Sánchez S, Bills GF and Zabalgogeazcoa I Fungal endophytes from two sympatric coastal grasses. Fungal Divers 2008, 33: 87-100 – Article
Singh SB, Zink DL, Herath KB, Salazar O and Genilloud O Discovery and antibacterial activity of lucensimycin C from Streptomyces lucensis. Tetrahedron Lett 2008, 49: 2616-2619 – Abstract
Zhang CW, Occi J, Masurekar P, Barrett JF, Zink DL, Smith S, Onishi R, Ha SH, Salazar O, Genilloud O, Basilio A, Vicente F, Gill C, Hickey EJ, Dorso K, Motyl M and Singh SB Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347. J Am Chem Soc 2008, 130: 12102-12110 – Abstract
Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Bills G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure, and antibacterial activity of phaeosphenone from a Phaeosphaeria sp discovered by antisense strategy. J Nat Prod 2008, 71: 1304-1307 – Abstract
2026
Martínez-Arribas B, Díaz-González R, Weaver J, Walden M, Mackenzie C, Dounay AB, Ramos MC, Genilloud O, Ruiz-Pérez LM, Mottinelli M, Ferrins L, González-Pacanowska D. Identification of 1,2-dihydroquinazolin-2-ones kinase inhibitors as anti-coronavirus agents. Antiviral Res. 2026 Sep 15:106534. doi: 10.1016/j.antiviral.2026.106534 Abstract
Guerra-Mateo D, González-Menéndez V, Gené J, Crous PW, Bensch K, Genilloud O, Cano-Lira JF. Novel insights into the phylogenetic and metabolic diversity of preussia-like fungi. Stud Mycol. 2026 May 20;114:437-486. doi: 10.3114/sim.2026.114.03 Abstract
Melong R, Tchamgoue J, Tsamo AT, Dzoyem JP, Annang FB, Gelbcke M, Meyer F, Wabo Fotso Kapche GD, Reyes F, Kouam SF. Mass spectrometry-guided isolation of paecilamide, A new hybrid alkylated pyridine amide alkaloid from Paecilomyces dactylethromorphus CECA 108. Phytochem. Lett. Volume 76,2026, 104253, ISSN 1874-3900 doi: 10.1016/j.phytol.2026.104253 Abstract
Rubini D, Parra-López M, Holzerland J, Rodríguez-Martínez A, Martina MG, Valenti ME, Ramos MC, Castillo F, Harty RN, Lanko K, Bauer L, Pérez-Sanchez H, Diederich S, Luque I, Radi M. Discovery of a novel class of broad-spectrum antivirals targeting the UEV domain of TSG101 in the host ESCRT pathway. Eur J Med Chem. 2026 Jul 17;318:119162. doi: 10.1016/j.ejmech.2026.119162 Abstract
Pecin G, Gonzalez-Menendez V, Martin J, Annang F, Mackenzie TA, Reyes F, Genilloud O. Discovery of spectabilide A, a new cytotoxic cyclic lipodepsipeptide from Trichothecium spectabile comb. nov. (Ascomycota, Sordariomycetes) revealed by OSMAC-guided metabolomics. IMA Fungus 17: e192814. https://doi.org/10.3897/imafungus.17.192814 Abstract
Baek KH, Lee H, Byun S, Genilloud O, Ioset JR, Shum D, No JH. In vitro profiling of Trypanosoma cruzi inhibitors identified from High throughput Screening and application to parasite painting. Int J Parasitol Drugs Drug Resist. 2026 May 14:31:100651. doi: 10.1016/j.ijpddr.2026.100651 Abstract
Desai R, Preet G, Astakala RV, Romero-Otero A, Sanchez P, Mackenzie TA, Larsen TO, Ebel R, Jaspars M. An Exploratory LC-HRMS Metabolomics Study of Culture Medium-Dependent Metabolic Variation and Bioactivity in Ten Fungal StrainsInt. J Mol Sci. 2026 Apr 27;27(9):3866. doi: 10.3390/ijms27093866 Abstract
Karyofyllidou G, Serrano R, González-Menéndez V, Martín J, Mackenzie TA, Ramos MC, Ortega-Vidal J, Thomas OP, Tormo JR, Genilloud O, Reyes F. Sulphopreussomerins: Sulfur-Containing Preussomerins Isolated from the Marine-Derived Fungus Pyrenochaetopsis indica. J Nat Prod. 2026 May 15. doi: 10.1021/acs.jnatprod.6c00324 Abstract
Larnder AH, Murphy RA, Srour B, Déchamp N, Galan P, Hercberg S, Bourhis L, Díaz C, Genilloud O, Touvier M, Deschasaux-Tanguy M. Plasma metabolites, dietary intakes, and breast cancer incidence: a prospective case-cohort study in NutriNet-Santé. Am J Clin Nutr. 2026 May 9:101342. doi: 10.1016/j.ajcnut.2026.101342 Abstract
Becerril A, Pérez-Victoria I, Martín J, Salas JA, Reyes F, Méndez C. Parallel Pathways and Alternative Macrocyclizations in the Biosynthesis of Largimycins by Cytochrome P450 Minus Mutants of Streptomyces argillaceus. J Nat Prod. 2026 May 7. doi: 10.1021/acs.jnatprod.6c00240 Abstract
Tocino-Márquez I, Zehl M, Batajic J, Séneca J, Pjevac P, Murillo-Alba J, Martín J, Sekurova ON, Zotchev SB. Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments. Front Microbiol. 2026 Apr 20;17:1793713. doi: 10.3389/fmicb.2026.1793713 Abstract
Bernabeu-Sanchis A, Mackenzie TA, Ramos MC, García A, Villarroel-Vicente C, Vila L, Tormo JR, Cortes D, Cabedo N. Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines. ChemMedChem. 2026 Jan; 21(2):e202500904. Abstract
Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Martín J, Tormo JR, Cho A, Byun SY, Shum D, Ioset JR, Reyes F, Genilloud O. Kronopolitides A-F, a Family of 36-Membered Polyol Macrolides with Antiparasitic Activity against Chagas Disease. J Nat Prod. 2026 Jan 23;89(1):170-188. Abstract
Duncan H, Domingo-Contreras E, Athanasiou S, Fernandez-Godino R, Castillo F, Camacho A. Affinity-based selection of anti-Feline Leukaemia Virus p27 monoclonal antibodies for efficient lateral flow assay development. Anal Biochem. 2026 Feb;709:116013. Abstract
Rodríguez-Pérez C, Vázquez-Aguilar A, Rangel Huerta OD, Sánchez-Rodríguez E, Gil Á, Díaz C, Vargas F, Mesa MD. New insights into the plasma and urinary metabolomic signatures of spontaneously hypertensive rats. PLoS One. 2026 Apr 3;21(4):e0344682. doi: 10.1371/journal.pone.0344682 Abstract
Machushynets NV, Elsayed SS, Du C, Lysenko V, de la Cruz M, Sanchez P, Genilloud O, Martin NI, Liles MR, van Wezel GP. Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated Paenibacillus species. mSystems. 2026 Mar 24;11(3):e0149625. doi: 10.1128/msystems.01496-25 Abstract
2025
Jennings L K, Kaur N, Ramos MC, de la Cruz M, Reddy MM, Reyes F, Thomas OP. Ascidiolides, nitrogenous phthalides from the solitary ascidian Ascidia virginea from the Northeastern Atlantic, and structural revision of the closely related ascidines. Organic & Biomolecular Chemistry. 1477-0520. Abstract
Castillo F, Mackenzie TS, Domingo E, Iañez I, Robers MB, Wilkinson J, Kay-Tsumagari E, O’Brien M, Genilloud O, Fernandez-Godino R, Ramos MC. Identification of novel inflammasome inhibitors via cellular NLRP3 target engagement assays. SLAS Discovery. Volume 35, 2025, Abstract
Fernández-Pastor I, González-Menéndez V, González I, Sanchez P, Serrano R, Mackenzie TA, Oves-Costales D, Casares Porcel M,Genilloud O, Reyes F. Glycinocins E–H, Antimicrobial Lipopeptides Produced by a Streptomyces Strain. Journal of Natural Products. 2025/08/22. Abstract
Serrano R, González-Menéndez V, Pérez-Victoria I, Sánchez I, Toro C, Mackenzie TA, Martín J, Tormo JR, Genilloud O. Leaf litter associated fungi from South Africa to control fungal plant pathogens. Scientific Reports, 15, 30219 (2025). Abstract
Azpiazu-Muniozguren M, Valgañón-Pérez E, García-Martínez M, Rodriguez-Paniagua A, Clark H P, Justicia C, Martín J, de la Cruz M, Reyes F, Laorden L, Martinez-Malaxetxebarria I, Martinez-Ballesteros I. Isolation of Halophilic and Halotolerant Bacterial Strains, Screening for Bioactive Compounds and Characterisation of Metabolites Produced by Pseudoalteromonas sp. ASV78. Environmental Microbiology Reports, 17, no. 4: e70159. Abstract
Annang FB, Pérez-Moreno G, Bosch-Navarrete C, González-Menéndez V, Martín J, Pérez-Bonilla M, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. Bovistols E and F, New bis-Sesquiterpenes Isolated From Psathyrella microrhiza CF-117891. Chemistry & Biodiversity. e00538. Abstract
Ortiz-López FJ, Oves-Costales D, Murillo-Alba J, Martín J, Díaz C, de la Cruz M, Jørgensen TS, Reyes F, Weber T, Genilloud O. Dracomicins, Hybrid Oligosaccharide–Nonribosomal Peptide Antibiotics from Amycolatopsis Species. Organic Letters, 2025, ASAP (June 3). Abstract
Ruiz-Jiménez AL, Heredia G, Peraza-Jiménez K, Felicia A, Vicente F,de la Cruz M, de Pedro N, Martín J, Reyes F, Gamboa-Angulo M. Beltraniella portoricensis strain MRH42, a saprophytic fungus from Mexico, produces antimicrobial and cytotoxic hymenopsins. Letters in Applied Microbiology. Volume 78, Issue 3, March 2025, ovaf023. Abstract
Vitorino IR, Santos JDN, Crespo G, Pérez-Victoria I, Martín J, Rodriguez L, Ramos MC, Martins TP, Leão PN, Vicente F, Vasconcelos V, Lage OM, Reyes F. Alichondrichlorin, a Novel Chlorohydrin-Containing Natural Product With Tumoral Cytotoxic Activity Isolated From the Planctomycetota Bacterium Alienimonas chondri LzC2T. Microbial Biotechnology. Volume18, Issue2, February 2025. e70076 Abstract
Tenorio CM, Nerea M. Molina, Castilla JA, Rodríguez-Guirado S, Méndez R, Fernández-Godino R, Altmäe S, Díaz C. Refining the seminal biomarker detection: metabolome profiles before and after the liquefaction procedure. Reproductive BioMedicine Online, 2025, 104856, Abstract
Wolff C, Neuenschwander M, Beese CJ,Sitani D, Ramos MC, Srovnalova A, Varela MJ, Polishchuk P, Skopelitou KE, Skuta C, Stechmann B, Brea J, ClausenMH, Dzubak P, Fernández-Godino R, Genilloud O, Hajduch M, Loza MI, Lehmann M , von Kries JP, Sun H, Schmied C. Morphological profiling data resource enables prediction of chemical compound properties. Iscience Open Access, Volume 28, Issue 5112445May 16, 2025. Abstract
Rodríguez-Martínez A, Giraldo-Ruiz L, Ramos MC, Luque I, Ribeiro D, Postigo-Corrales F, Alburquerque-González B, Montoro-García S, Arroyo-Rodríguez AB, Conesa-Zamora P, Hurtado AM, Luengo-Gil G, Pérez-Sánchez H. Discovery of Z1362873773: a novel fascin inhibitor from a large chemical library for colorectal cancer. Scientific Reports, 15, 14906 (2025). Abstract
Carretero-Ledesma M, Li J, Martín-Escolano J, Herrera-Espejo S, Xu J, Chen H, Díaz-Navarro C, Pachón J, Sánchez-Céspedes J, Zhou J, Pachón-Ibáñez ME. Salicylamide derivative JMX0312 protects immunosuppressed Syrian hamsters against adenovirus lethal challenge. Antiviral Research,Volume 238,2025, 106155. Abstract
Gadiya Y, Genilloud O, Bilitewski U, Brönstrup M, von Berlin L, Attwood M, Gribbon P, Zaliani A. Predicting Antimicrobial Class Specificity of Small Molecules Using Machine Learning. Journal of Chemical Information and Modeling. 2025 Mar 10;65(5):2416-2431. Abstract
Armento A, Sonntag I, Almansa-Garcia AC, Sen M, Bolz S, Arango-Gonzalez B, Kilger E, Sharma R, Bharti K, Fernandez-Godino R, de la Cerda B, Clark SJ, Ueffing M. The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells. Frontiers in Immunology. 16:1527018. doi: Abstract
Camacho J, Armstrong MS, García-Martínez L, Díaz C, Gómez-Llorente C. Single-cell spatial (scs) omics: Recent developments in data analysis. TrAC Trends in Analytical Chemistry, Volume 183, 2025, 118109. Abstract
Aguirrebengoa M, Moreno B, GuiradoN. Microbe-mediated organic fertilization increases insect predator attraction upon fruit damage in olive trees. Soil Ecology Letters. 7, 240281 (2025). Abstract
Pérez-Victoria I, El Aouad N, González-Menéndez V, de La Cruz, M, Fernández L, Martín J, Tormo JR, Genta-Jouve G, Thomas OP,Vicente F, Bills GF, Genilloud O, Reyes F. MDN-0057 to MDN-0060, a Family of Broad-Spectrum Antibiotics against Gram-Negative Pathogens Produced by Ophiosphaerella korrae. Journal of Natural Products, 2025. Abstract
Bagán A, López-Ruiz A, Abás S, Ruiz-Cantero MC, Vasilopoulou F, Taboada-Jara T, Griñán-Ferré C, Pallàs M, Muguruza C, Diez-Alarcia R, Callado LF, Entrena JM, Cobos EJ, Pérez B, Morales-García JA, Molins E, De Jonghe S, Daelemans D, Brea J, Val C, Loza MI, Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ, Díaz C, Fernández-Godino R, Genilloud O, Beljkaš M, Oljačić S, Nikolic K, Escolano C. Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2 H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties. Journal of Medicinal Chemistry. 2025 Feb 13;68(3):2551-2573. Abstract
Georgousaki K, Tsafantakis N, González I, Martin J, Mackenzie TA, Gumeni S, Trougakos IP, Reyes F, Genilloud O, Fokialakis N. Isolation, Spectral Assignments and Absolute Configuration of a Linear Hexapeptide from the Culture Broth of the Plant-Associated Actinomycete Actinomycetospora sp. CA-287887. Separations. 2025, 12, 57. Abstract
Montero F, Parra-López M, Rodríguez-Martínez A, Murciano-Calles J, Buzon P, Han Z, Lin LY, Ramos MC, Ruiz-Sanz J, Martinez JC, Radi M, Moog C, Diederich S, Harty RN, Pérez-Sánchez H, Vicente F, Castillo F, Luque I. Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals. Protein Science. 2025 Jan;34(1):e70005. Abstract
2024
Vicente F, Reyes F, Genilloud O. Fungerps: discovery of the glucan synthase inhibitor enfumafungin and development of a new class of antifungal triterpene glycosides. Natural Product Reports, 2024, Advance Article. org/10.1039/D4NP00044G Abstract
Prado-Alonso L, Ye S, Pérez-Victoria I, Montero I, Riesco P, Ortiz-López FJ, Martín J, Olano C, Reyes F, Méndez C. Genome Mining for Diazo-Synthesis-Related Genes in Streptomyces sp. CS057 Unveiled the Cryptic Biosynthetic Gene Cluster crx for the Novel 3,4-AHBA-Derived Compound Crexazone 2. Biomolecules. 2024; 14(9):1084. https://doi.org/10.3390/biom14091084 Abstract
Ortiz-López FJ, Oves-Costales D, Guerrero Garzón JF, Gren T, Baggesgaard Sterndorff E, Jiang X, Sparholt Jo̷rgensen T, Blin K, Fernández-Pastor I, Tormo JR, Martín J, Sánchez P, de la Cruz Moreno M, Reyes F, Genilloud O, Weber T. Genome-Led Discovery of the Antibacterial Cyclic Lipopeptide Kutzneridine A and Its Silent Biosynthetic Gene Cluster from Kutzneria Species Journal of Natural Products, 2024, 87, 2515-2522. DOI: 10.1021/acs.jnatprod.4c00633 Abstract
Jover I, Ramos M., Escámez MJ, Lozoya E, Tormo JR, de Prado-Verdún D, Mencía A, Pont M, Puig C, Larraufie MH, Gutiérrez-Caballero C, Reyes F, Trincado JL, García-González V, Cerrato R, Andrés M, Crespo M, Vicente F, Godessart N, Genilloud O, Larcher F, Nueda A. Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa. Scientific Reports 14, 18969 (2024). https://doi.org/10.1038/s41598-024-67398-8 Abstract
Pérez-Victoria I. Natural Products Dereplication: Databases and Analytical Methods. Progress in the Chemistry of Organic Natural Products, vol 124. Springer Nature, Cham. https://doi.org/10.1007/978-3-031-59567-7_1 Abstract
Fernández-Pastor I, González-Menéndez V, González I, Serrano R, Mackenzie TA, Benítez G, Casares-Porcel M, Genilloud O, Reyes F. Escuzarmycins A–D, Potent Biofungicides to Control Septoria tritici Blotch. Journal of Agricultural and Food Chemistry 2024 72 (27), 15256-15264. DOI: 10.1021/acs.jafc.4c01303 Abstract
Palma-Morales M, Daniel Rangel-Huerta O, Díaz C, Castilla-Ortega E, Rodríguez-Pérez C. Integration of network-based approaches for assessing variations in metabolic profiles of alkalized and non-alkalized commercial cocoa powders. Food Chemistry: X, 2024, 101651, ISSN 2590-1575, https://doi.org/10.1016/j.fochx.2024.101651 Abstract
Ramos MC, Crespo-Sueiro G, de Pedro N, Griñán-Lisón C, Díaz C, Pérez-Victoria I, González-Menéndez V, Castillo F, Pérez del Palacio J, Tormo JR, Choquesillo-Lazarte D, Marchal JA, Vicente F, Fernández-Godino R, Genilloud O, Reyes F. Onychocolone A produced by the fungus Onychocola targets cancer stem cells and stops pancreatic cancer progression by inhibiting MEK2-dependent cell signaling. Biomedicine & Pharmacotherapy, Volume 177, 2024, 117018, https://doi.org/10.1016/j.biopha.2024.117018. Abstract
Girao M, Murillo-Alba J, Martín J, Pérez-Victoria I, Leite RB, Urbatzka R, Leao PN, Carvalho MF, Reyes F. Cellulamides: a new Family of Marine-sourced Linear Peptides from the Underexplored Cellulosimicrobium Genus. Marine Drugs. 2024, 22, 268. https://doi.org/10.3390/md22060268 Abstract
Castillo F, Ramírez D, Ramos MC, Martinez-Arribas B, Domingo-Contreras E, Mackenzie TA, Peña-Varas C, Lindemann S, Montero F, Annang F, Vicente F, Genilloud O, González-Pacanowska D, Fernandez-Godino R. Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broadspectrum antivirals. Frontiers in Pharmacology. 15:1390705. doi: 10.3389/fphar.2024.1390705 Abstract
Mackenzie TA, Tormo JR, Cautain B, Martínez G, Sánchez I, Genilloud O, Vicente F, Ramos MC. Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products. SLAS Technology. 2024 Jun;29(3):100111. doi: 10.1016/j.slast.2023.10.003. Abstract
Olmedo CG, Beltrán LD, García VM, Ferrer JLP, Jiménez AC, Cubero RU, del Palacio JP, Díaz C, Vicente F, Rovira PS. Assessment of Untargeted Metabolomics by Hydrophilic Interaction Liquid Chromatography−Mass Spectrometry to Define Breast Cancer Liquid Biopsy-Based Biomarkers in Plasma Samples. International Journal of Molecular Sciences. 2024; 25(10):5098. https://doi.org/10.3390/ijms25105098 Abstract
Álvarez-León F, Rosado-Aguilar JA, Gamboa-Angulo M, Flota-Burgos GJ, Martin J, Reyes F. Anthelmintic activity and chemical profile of native plant extracts from the Yucatan Peninsula against Toxocara canis. Acta Tropica. 2024 Jul;255:107214. doi: 10.1016/j.actatropica.2024.107214 Abstract
Virués-Segovia JR, Pinedo C, Zorrilla D, Sánchez-Márquez J, Sánchez P, Ramos MC, de la Cruz M, Aleu J and Durán-Patrón R. Discovery of new eremophilanes from the marine-derived fungus Emericellopsis maritima BC17 by culture conditions changes: evaluation of cytotoxic and antimicrobial activities. Frontiers in Marine Science. 11:1386175. doi: 10.3389/fmars.2024.1386175 Abstract
Jennings LK, Kaur N, Ramos MC, Reyes F, Reddy MM, Thomas OP. Highly Concentrated Linear Guanidine Amides from the Marine Sipunculid Phascolosoma granulatum. Journal of Natural Products. 2024. DOI: 10.1021/acs.jnatprod.3c01186 Abstract
Esquivel-Chi MC, Ruiz-Sánchez E, Ballina-Gómez H, Martín J, Reyes F, Carnevali G, Tapia-Muñoz JL, Gamboa-Angulo M. Repellent screening of ethanol extracts from plants of the Yucatan Peninsula against Bemisia tabaci (Gennadius, 1889) and chemical profile of Malpighia glabra L. leaves. Journal of Plant Diseases and Protection 131, 811–821 (2024). https://doi.org/10.1007/s41348-024-00901-5 Abstract
Domingo-Contreras E, Tormo JR, González V, Mackenzie TA, Martín-Serrano J, Magiera-Mularz K, Kitel R, Reyes F, Genilloud O, Fernández R, Ramos MC, Castillo F. Discovery of bioactive natural products of microbial origin as inhibitors of the PD-1/PD-L1 protein-protein interaction. International Journal of Biological Macromolecules, Volume 264, Part 1, 2024, 130458. https://doi.org/10.1016/j.ijbiomac.2024.130458. Abstract
García-Gutiérrez C, Pérez-Victoria I, Montero I, Fernández-De la Hoz J, Malmierca MG, Martín J, Salas JA, Olano C, Reyes F, Méndez C. Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller Streptomyces CS113. International Journal of Molecular Sciences. 2024; 25(4):2347. https://doi.org/10.3390/ijms25042347 Abstract
Fernández-Pastor I, Ortiz-López FJ, Oves-Costales D, Martín J, Sánchez P, Melguizo Á, Reyes F, Weber T, Genilloud O. Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca2+-Binding Motif. Organic Letters. 2024 Feb 23;26(7):1343-1347. doi: 10.1021/acs.orglett.3c04195. Abstract
Vitorino IR, Pinto E, Martín J, Mackenzie TA, Ramos MC, Sánchez P, de la Cruz M, Vicente F, Vasconcelos V, Reyes F, Lage OM. Uncovering the biotechnological capacity of marine and brackish water Planctomycetota. Antonie Van Leeuwenhoek. 2024 Jan 23;117(1):26. doi: 10.1007/s10482-023-01923-z. Abstract
Mackenzie TA, Reyes F, Martínez M, González-Menéndez V, Sánchez I, Genilloud O, Tormo JR, Ramos MC. Naphthoquinone Derivatives from Angustimassarina populi CF-097565 Display Anti-Tumour Activity in 3D Cultures of Breast Cancer Cells. 2024; 29(2):425. https://doi.org/10.3390/molecules29020425 Abstract
Cabello-Donayre M, Cabello-Donayre I, Guerra D, Orrego LM, Morales JC, Cautain B, Vicente F, Pérez-Victoria JM. A yeast-based high-throughput screen identifies inhibitors of trypanosomatid HRG heme transporters with potent leishmanicidal and trypanocidal activity. International Journal of Antimicrobial Agents. 2024 Mar;63(3):107092. doi: 10.1016/j.ijantimicag.2024.107092. Abstract
González-Olmedo C, García-Verdejo FJ, Reguera-Teba A, Rosa-Garrido C, López-López JA, Díaz-Beltrán L, García PM, Luque-Caro N, Gálvez-Montosa F, Ortega-Granados AL, Ruiz-Sanjuan M, Cózar-Ibáñez A, Sainz J, Marchal JA, Camacho J, Del Palacio JP, Fernández-Godino R, Díaz C, Sánchez-Rovira P. Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis. Clinical and Translational Medicine. 2024 Jan;14(1):e1541. doi: 10.1002/ctm2.1541. Abstract
Dos Santos JDN, Pinto E, Martín J, Vicente F, Reyes F, Lage OM. Unveiling the bioactive potential of Actinomycetota from the Tagus River estuary. International Microbiology. 2024 Jan 18. doi: 10.1007/s10123-024-00483-0. Abstract
Kouam AF, Mabou FD, Fu L, Koagne RR, LI Y, Owona Ba, Zeuko’o EM, FEPA AGK, Galani BRT, Reyes F, Njayou FN, Moundipa PF, Gao GF. Insights into the inhibition mechanisms of MERS-CoV and SARS-CoV2 papain-like proteases by inhibitors from Crinum distichum: In vitro and in silico analysis. South African Journal of Botany. 2024, 165, 290-306. https://doi.org/10.1016/j.sajb.2024.01.004 Abstract
Peña-Martín J, García-Ortega MB, Palacios-Ferrer JL, Díaz C, Ángel García M, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias Santiago S, Vicente F, Del Val C, Pérez Del Palacio J, Marchal JA. Identification of novel biomarkers for early diagnosis of malignant melanoma by untargeted LC-HRMS-based metabolomics: a pilot study. British Journal of Dermatology. 2024 Jan 12:ljae013. doi: 1093/bjd/ljae013. Abstract
Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Oves-Costales D, Martín J, Murillo-Alba J, Tormo JR, Cho A, Byun SY, No JH, Shum D, Ioset JR, Genilloud O, Reyes F. Madurastatins with Imidazolidinone Rings: Natural Products or Side-Reaction Products from Extraction Solvents? International Journal of Molecular Sciences. 2024, 25(1):301. doi: 10.3390/ijms25010301. Abstract
Santos JDND, Klimek D, Calusinska M, Lobo-da-Cunha A, Catita J, Gonçalves H, González I, Lage OM. Microbacterium memoriense nov., a member of the Actinomycetota from marine beach sediment of the north coast of Portugal. International Journal of Systematic and Evolutionary Microbiology. 2024 Jan;74(1). doi: 10.1099/ijsem.0.006230. Abstract
Matias-Valiente L, Sanchez-Fernandez C, Rodriguez-Outeiriño L, Ramos MC, Díaz C, Crespo G, González-Menéndez V, Genilloud O, Reyes F, Montolio M, Hernandez-Torres F, Aranega AE. Evaluation of pro-regenerative and anti-inflammatory effects of isolecanoric acid in the muscle: Potential treatment of Duchenne Muscular Dystrophy. Biomedicine & Pharmacotherapy. Volume 170, January 2024, 116056. doi: 10.1016/j.biopha.2023.116056. Abstract
Resa S, González M, Reyes F, Pérez-Victoria I. Revision of the full stereochemistry of telomycin. Organic Chemistry Frontiers, 2024, 11, 306-314. https://doi.org/10.1039/D3QO01411H Abstract
Martínez-Arribas B, Annang F, Díaz-González R, Pérez-Moreno G, Martín J, Mackenzie TA, Castillo F, Reyes F, Genilloud O, Ruiz-Pérez LM, Vicente F, Ramos MC, González-Pacanowska D. Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity. Microbiology Spectrum. 2024 Jan 11;12(1):e0167923. doi: 10.1128/spectrum.01679-23. Abstract
2023
O’Brien S, Lacret R, Reddy MM, Jennings LK, Sánchez P, Reyes F, Mungkaje A, Calabro K, Thomas OP. Additional Sarasinosides from the Marine Sponge Melophlus sarasinorum Collected from the Bismarck Sea. Journal of Natural Products, 2023, https://doi.org/10.1021/acs.jnatprod.3c01045 Abstract
Martínez-Arribas B, Annang F, Díaz-González R, Pérez-Moreno G, Martín J, Mackenzie TA, Castillo F, Reyes F, Genilloud O, Ruiz-Pérez LM, Vicente F, Ramos MC, González-Pacanowska D. Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity. Microbiology Spectrum. DOI: https://doi.org/10.1128/spectrum.01679-23 Abstract
Resa S, González M, Reyes F, Pérez-Victoria I. Revision of the full stereochemistry of telomycin. Organic Chemistry Frontiers, 2023, https://doi.org/10.1039/D3QO01411H Abstract
Matilla MA, Evans TJ, Martín J, Udaondo Z, Lomas-Martínez C, Rico-Jiménez M, Reyes F, Salmond GPC. Herbicolin A production and its modulation by quorum sensing in a Pantoea agglomerans rhizobacterium bioactive against a broad spectrum of plant-pathogenic fungi. Microbial Biotechnology. 2023; 16:c 1690-1700. https://ami-journals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.14193 Abstract
Santamaría RI, Martínez-Carrasco A, Tormo JR, Martín J, Genilloud O, Reyes F, Díaz M. Interactions of Different Streptomyces Species and Myxococcus xanthus Affect Myxococcus Development and Induce the Production of DK-Xanthenes. International Journal of Molecular Sciences. 2023; 24(21):15659. https://doi.org/10.3390/ijms242115659 Abstract
Thomas A. Mackenzie, José R. Tormo, Bastien Cautain, Germán Martínez, Isabel Sánchez, Olga Genilloud, Francisca Vicente, Maria C. Ramos. Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products. SLAS Technology, 2023, ISSN 2472-6303, https://doi.org/10.1016/j.slast.2023.10.003 Abstract
Fernández-Pastor I, González-Menéndez V, Martínez Andrade K, Serrano R, Mackenzie TA, Benítez G, Casares-Porcel M, Genilloud O, Reyes F. Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides. Journal of Fungi. 2023; 9(9):887. https://doi.org/10.3390/jof9090887 Abstract
Bagán A, Rodriguez-Arévalo S, Taboada-Jara T, Griñán-Ferré C, Pallàs M, Brocos-Mosquera I, Callado LF, Morales-García JA, Pérez B, Diaz C. Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease. Pharmaceutics. 2023; 15(10):2381. https://doi.org/10.3390/pharmaceutics15102381 Abstract
Serrano R, González-Menéndez V, Tormo JR, Genilloud O. Development and Validation of a HTS Platform for the Discovery of New Antifungal Agents against Four Relevant Fungal Phytopathogens. Journal of Fungi. 2023; 9(9):883. https://doi.org/10.3390/jof9090883 Abstract
Kokkini M, Oves-Costales D, Sánchez P, Melguizo Á, Mackenzie TA, Pérez-Bonilla M, Martín J, Giusti A, de Witte P, Vicente F, Genilloud O, Reyes F. New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains. Marine Drugs. 2023 Aug 7;21(8):443. doi:10.3390/md21080443. Abstract
Huang W, Rodrigues J, Bilgo E, Tormo JR, Challenger JD, De Cozar-Gallardo C, Pérez-Victoria I, Reyes F, Castañeda-Casado P, Gnambani EJ, Hien DFS, Konkobo M, Urones B, Coppens I, Mendoza-Losana A, Ballell L, Diabate A, Churcher TS, Jacobs-Lorena M. Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes. Science. 2023 Aug 4;381(6657):533-540. doi: 10.1126/science.adf8141. Abstract
Rodríguez-Ruiz M, Ramos MC, Campos MJ, Díaz-Sánchez I, Cautain B, Mackenzie TA, Vicente F, Corpas FJ, Palma JM. Pepper Fruit Extracts Show Anti-Proliferative Activity against Tumor Cells Altering Their NADPH-Generating Dehydrogenase and Catalase Profiles. Antioxidants. 2023; 12(7):1461. https://doi.org/10.3390/antiox12071461 Abstract
Palma JM, Pérez del Palacio J, Rodríguez-Ruiz M, González-Gordo S, Caridad Díaz C, Ramos MC, Cautain B, Vicente F, Corpas FJ (2023). Nitric Oxide in Health and Disease. Therapeutic Applications in Cancer and Inflammatory Disorders (Morbidelli L, Bonavida B, Muntané J, eds.) pp. 193-210, Chapter 8 – Pepper fruit, as a nutraceutical food, shows antiproliferative activity against tumor cells and it is potentiatied by nitric oxide (NO). Academic Press-Elsevier. https://doi.org/10.1016/B978-0-443-13342-8.00012-0 Abstract
Ye S, Molloy B, Pérez-Victoria I, Montero I, Braña AF, Olano C, Arca S, Martín J, Reyes F, Salas JA, Méndez C. Uncovering the Cryptic Gene Cluster ahb for 3-amino-4-hydroxybenzoate Derived Ahbamycins, by Searching SARP Regulator Encoding Genes in the Streptomyces argillaceus Genome. International Journal of Molecular Sciences. 2023 May 3;24(9):8197. doi: 10.3390/ijms24098197. Abstract
Gaudêncio SP, Bayram E, Lukić Bilela L, Cueto M, Díaz-Marrero AR, Haznedaroglu BZ, Jimenez C, Mandalakis M, Pereira F, Reyes F, Tasdemir D. Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation. Marine Drugs. 2023 May 19;21(5):308. doi: 10.3390/md21050308. Abstract
Ortiz-López F J, Oves-Costales D, Carretero-Molina D, Martín J, Díaz C, de la Cruz M, Román-Hurtado F, Álvarez-Arévalo M, Jørgensen T, Reyes F, Weber T, Genilloud O. Crossiellidines A–F, Unprecedented Pyrazine-Alkylguanidine Metabolites with Broad-Spectrum Antibacterial Activity from Crossiella sp. Organic Letters. 2023, May 10. https://doi.org/10.1021/acs.orglett.3c01088 Abstract
Molina-Tijeras JA, Ruiz-Malagón AJ, Hidalgo-García L, Diez-Echave P, Rodríguez-Sojo MJ, Cádiz-Gurrea MdlL, Segura-Carretero A, del Palacio JP, González-Tejero MR, Rodríguez-Cabezas ME, Gálvez J, Rodríguez-Nogales A, Vezza T, Algieri F. The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice. Antioxidants. 2023; 12(4):832. https://doi.org/10.3390/antiox12040832 Abstract
Deisinger JP, Arts M, Kotsogianni I, Puls JS, Grein F, Ortiz-López FJ, Martin NI , Müller A, Genilloud O, Schneider T. Dual targeting of the class V lanthipeptide antibiotic cacaoidin. iScience. 2023 Mar 11;26(4):106394. doi: 10.1016/j.isci.2023.106394. Abstract
Durcik M, Cotman A E, Toplak Z, Možina S, Skok Ž, Szili P E, Czikkely M, Maharramov E, Vu TH, Piras M V, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo L A, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol S V, Jin Z, Vicente F, Ramos M C, Mundy J E A, Maxwell A, Stevenson C A M, D M Lawson, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen G V, Sterk G J, Kikelj D, Pal C, Tomašič T, Mašič L P. New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus. Journal of Medicinal Chemistry. 2023 66 (6), 3968-3994 DOI: 10.1021/acs.jmedchem.2c01905 Abstract
Acebedo-Martínez FJ, Alarcón-Payer C, Verdugo-Escamilla C, Martín J, Frontera A, Domínguez-Martín A, Gómez-Morales J, Choquesillo-Lazarte D. Rational Coformer Selection in the Development of 6-Propyl-2-thiouracil Pharmaceutical Cocrystals. Pharmaceuticals. 2023; 16(3):370. https://doi.org/10.3390/ph16030370 Abstract
Annang FB, Pérez-Moreno G, Bosch-Navarrete C, González-Menéndez V, Martín J, Mackenzie TA, Ramos MC, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171. Pharmaceutics. 2023; 15(2):492. https://doi.org/10.3390/pharmaceutics15020492 Abstract
Sánchez-Hidalgo M, García MJ, González I, Oves-Costales D, Genilloud O. Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters. Microorganisms. 2023; 11(2):265. https://doi.org/10.3390/microorganisms11020265 Abstract
Díaz C, González-Olmedo C. Untargeted Metabolomics by Liquid Chromatography-Mass Spectrometry in Biomedical Research. Methods in Molecular Biology. 2023;2571:57-69. doi: 10.1007/978-1-0716-2699-3_6. Abstract
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D. Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa. Journal of Medicinal Chemistry. 2023 Jan 12. doi: 10.1021/acs.jmedchem.2c01597 Abstract
Gattoni G, de la Haba RR, Martín J, Reyes F, Sánchez-Porro C, Feola A, Zuchegna C, Guerrero-Flores S, Varcamonti M, Ricca E, Selem-Mojica N, Ventosa A and Corral P. Genomic study and lipidomic bioassay of Leeuwenhoekiella parthenopeia: A novel rare biosphere marine bacterium that inhibits tumor cell viability. Frontiers in Microbiology. 13:1090197. doi: 10.3389/fmicb.2022.1090197 Abstract
Oves-Costales D, Gren T, Baggesgaard Sterndorff E, Martín J, Ortiz-López FJ, Jørgensen TS, Jiang X, Román-Hurtado F, Reyes F, Genilloud O, Weber T. Identification and heterologous expression of the globomycin biosynthetic gene cluster. Synthetic and Systems Biotechnology. Volume 8, Issue 2, 2023, Pages 206-212. https://doi.org/10.1016/j.synbio.2023.02.001. Abstract
Diyaolu OA, Preet G, Fagbemi AA, Annang F, Pérez-Moreno G, Bosch-Navarrete C, Adebisi OO, Oluwabusola ET, Milne BF, Jaspars M, Ebel R. Antiparasitic Activities of Compounds Isolated from Aspergillus fumigatus Strain Discovered in Northcentral Nigeria. Antibiotics (Basel). 2023 Jan 6;12(1):109. doi: 10.3390/antibiotics12010109 Abstract
2022
dos Santos JDN, João SA, Martín J, Vicente F, Reyes F, Lage OM. iChip-Inspired Isolation, Bioactivities and Dereplication of Actinomycetota from Portuguese Beach Sediments. Microorganisms. 2022; 10(7):1471. https://doi.org/10.3390/microorganisms10071471 Abstract
Jimenez L, Amenabar C, Mayoral-Varo V, Mackenzie TA, Ramos MC, Silva A, Calissi G, Grenho I, Blanco-Aparicio C, Pastor J, Megías D, Ferreira BI, Link W. mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity. Molecules. 2022; 27(17):5414. https://doi.org/10.3390/molecules27175414 Abstract
Rodríguez-Ruiz M, Ramos C, Campos MJ, Vicente F, Corpas FJ, Palma JM. Crude extracts from pepper fruits show anti-proliferative activity against tumor cells altering their catalase and glucose-6-phosphate dehydrogenase profile. Free Radical Biology and Medicine, 2022, Vol 189, Supplement 1, 40-41. https://doi.org/10.1016/j.freeradbiomed.2022.06.172 Abstract
Rodríguez-Ruiz M, Pérez de Palacio J, González-Gordo S, Díaz C, Ramos C, Vicente F, Palma JM, Corpas FJ. Compounds from sweet pepper (Capsicum annuum l.) fruits with potential therapeutic uses are boosted by nitric nitric oxide (NO). Free Radical Biology and Medicine, 2022, Vol 189, Supplement 1, 41, https://doi.org/10.1016/j.freeradbiomed.2022.06.173 Abstract
Virués-Segovia JR, Reyes F, Ruíz S, Martín J, Fernández-Pastor I, Justicia C, de la Cruz M, Díaz C, Mackenzie TA, Genilloud O, González I, Tormo JR. Kribbellichelins A and B, Two New Antibiotics from Kribbella sp. CA-293567 with Activity against Several Human Pathogens. Molecules. 2022; 27(19):6355. https://doi.org/10.3390/molecules27196355 Abstract
Riccio G, Martinez KA, Martín J, Reyes F, D’Ambra I, Lauritano C. Jellyfish as an Alternative Source of Bioactive Antiproliferative Compounds. Marine Drugs. 2022 May 25;20(6):350. doi: 10.3390/md20060350. Abstract
Nielsen JB, Gren T, Mohite OS, Jørgensen TS, Klitgaard AK, Mourched AS, Blin K, Oves-Costales D, Genilloud O, Larsen TO, Tanner D, Weber T, Gotfredsen CH, Charusanti P. Identification of the Biosynthetic Gene Cluster for Pyracrimycin A, an Antibiotic Produced by Streptomyces sp. ACS Chemical Biology. 2022 Sep 16;17(9):2411-2417. doi: 10.1021/acschembio.2c00480. Abstract
Liang H, Lopez IJ, Sánchez-Hidalgo M, Genilloud O, van der Donk WA. Mechanistic Studies on Dehydration in Class V Lanthipeptides. ACS Chemical Biology. 2022 Sep 16;17(9):2519-2527. doi: 10.1021/acschembio.2c00458 Abstract
Díaz C, González-Olmedo C. Untargeted Metabolomics by Liquid Chromatography-Mass Spectrometry in Biomedical Research. Methods in Molecular Biology. 2023;2571:57-69. doi: 10.1007/978-1-0716-2699-3_6 Abstract
Pérez-Victoria I, Crespo G, Reyes F. Expanding the utility of Marfey’s analysis by using HPLC-SPE-NMR to determine the Cβ configuration of threonine and isoleucine residues in natural peptides. Analytical and Bioanalytical Chemistry. 2022 Nov;414(28):8063-8070. doi: 10.1007/s00216-022-04339-2 Abstract
Navarro JA, Díaz C, Decara J, Medina-Vera D, Lopez-Gambero AJ, Suarez J, Pavón FJ, Serrano A, Vargas A, Gavito AL, Porras-Perales O, Aranda J, Vicente F, Sanjuan C, Baixeras E, Fonseca FR. Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers. Nutrients. 2022 Oct 1;14(19):4094. doi: 10.3390/nu14194094 Abstract
Ye S, Ballin G, Pérez-Victoria I, Braña AF, Martín J, Reyes F, Salas JA, Méndez C. Combinatorial biosynthesis yields novel hybrid argimycin P alkaloids with diverse scaffolds in Streptomyces argillaceus. Applied Microbiology International. 2022 Nov 8. doi: 10.1111/1751-7915.14167 Abstract
Sarmiento-Vizcaíno A, Martín J, Ortiz-López FJ, Reyes F, García LA, Blanco G. Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin. Frontiers in Chemistry. 2022 Nov 3;10:948795. doi: 10.3389/fchem.2022.948795 Abstract
Vitorino IR, Lobo-da-Cunha A, Vasconcelos V, Vicente F, Lage OM. Isolation, diversity and antimicrobial activity of planctomycetes from the Tejo river estuary (Portugal). FEMS Microbiology Ecology, fiac066, https://doi.org/10.1093/femsec/fiac066. Abstract
Ortiz-Gonzalez M, Pérez-Victoria I, Ramirez-Macias I, De Pedro N, Linde-Rodriguez A, González-Menéndez V, Sanchez-Martin V, Martín J, Soriano-Lerma A, Genilloud O, Perez-Carrasco V, Vicente F, Maceira J, Rodrígues-Poveda CA, Navarro-Marí JM, Reyes F, Soriano M, Garcia-Salcedo JA. Curvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcription. International Journal of Molecular Sciences. 2022; 23(11):6107. https://doi.org/10.3390/ijms23116107 Abstract
Santamaría R I, Martínez-Carrasco A, Martín J, Tormo J R, Pérez-Victoria I, González I, Genilloud O, Reyes F, Díaz M. Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp. Antibiotics. 2022, 11(5), 672; https://doi.org/10.3390/antibiotics11050672 Abstract
Bagán A, Morales-García JA, Griñán-Ferré C, Díaz C, Pérez del Palacio J, Ramos MC, Vicente F, Pérez B, Brea J, Loza MI, Pallàs M, Escolano C. Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06. International Journal of Molecular Sciences. 2022; 23(10):5408. https://doi.org/10.3390/ijms23105408 Abstract
Riccio G, Martinez KA, Ianora A, Lauritano C. De Novo Transcriptome of the Flagellate Isochrysis galbana Identifies Genes Involved in the Metabolism of Antiproliferative Metabolites. Biology. 2022; 11(5):771. https://doi.org/10.3390/biology11050771 Abstract
Reyes F, Bills GF, Durán-Patrón R. Editorial: Strategies for the Discovery of Fungal Natural Products. Frontiers in Microbiology. 2022, Vol. 13. DOI=10.3389/fmicb.2022.897756. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus. Natural Product Research. 2022 Apr;36(8):2043-2048. doi:10.1080/14786419.2020.1844699. Abstract
Slemc L, Jakše J, Filisetti A, Baranasic D, Rodríguez-García A, Del Carratore F, Marino SM, Zucko J, Starcevic A, Šala M, Pérez-Bonilla M, Sánchez-Hidalgo M, González I, Reyes F, Genilloud O, Springthorpe V, Goranovič D, Kosec G, Thomas GH, Lucrezia D, Petković H, Tome M. Reference-Grade Genome and Large Linear Plasmid of Streptomyces rimosus: Pushing the Limits of Nanopore Sequencing. Microbiology Spectrum. 2022 Apr 4:e0243421. doi: 10.1128/spectrum.02434-21. Abstract
Machushynets N, Elsayed S, Du C, Siegler M, de la Cruz M, Genilloud O, Hankemeier T, van Wezel G. Discovery of actinomycin L, a new member of the actinomycin family of antibiotics. Scientific Reports, (2022), 2813, 12(1). https://doi.org/10.1038/s41598-022-06736-0 Abstract
Martinez JC, Castillo F, Ruiz-Sanz J, Murciano-Calles J, Camara-Artigas A, Luque I. Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families. Advances in Protein Chemistry and Structural Biology. ELSEVIER. 2022 Jan 10. https://doi.org/10.1016/bs.apcsb.2021.12.002. Abstract
Prado-Alonso L, Pérez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by Streptomyces sp. Strain CS147. Applied and Environmental Microbiology, 2022;88:e01839-21 https://journals.asm.org/doi/10.1128/AEM.01839-21 Abstract
Carretero-Molina D, Ortiz-López FJ, Gren T, Oves-Costales D, Martín J, Román-Hurtado F, Jørgensen TS, de la Cruz M, Díaz C, Vicente F, Blin K, Reyes F, Weber T, Genilloud O. Discovery of gargantulides B and C, new 52-membered macrolactones from Amycolatopsis sp. Complete absolute stereochemistry of the gargantulide family. Organic Chemistry Frontiers 2022; 9:462-70. https://doi.org/10.1039/D1QO01480C Abstract
Martínez KA, Saide A, Crespo G, Martín J, Romano G, Reyes F, Lauritano C, Iannora A. Promising Antiproliferative Compound from the Green Microalga Dunaliella tertiolecta Against Human Cancer Cells. Frontiers in Marine Science 2022; 9:778108. https://doi.org/10.3389/fmars.2022.778108 Abstract
Gimranov E, Santos JDN, Vitorino I, Martín J, Reyes F, Moura L, Tavares F, Santos C, Mariz-Ponte N, Lage OM. Marine bacterial activity against phytopathogenic Pseudomonas show high efficiency of Planctomycetes extracts. European Journal of Plant Pathology 2022; 162:843-54. https://doi.org/10.1007/s10658-021-02441-2 Abstract
Díaz C, González-Olmedo C, Díaz-Beltrán L, Camacho J, Mena García P, Martín-Blázquez A, Fernández-Navarro M, Ortega-Granados AL, Gálvez-Montosa F, Marchal JA, Vicente F, Pérez Del Palacio J, Sánchez-Rovira P. Predicting Dynamic response to neoadjuvant chemotherapy in breast cancer: a novel metabolomics approach. Molecular Oncology. 2022 Mar 26. doi: 10.1002/1878-0261.13216. Abstract
Ganesan A, Aldholmi M, Ahmad R, Carretero-Molina D, Pérez-Victoria I, Martín J, Reyes F, Genilloud O, Gourbeyre L, Gefflaut T, Carlsson H, Maklakov A, Field RA, O’Neill E, Wilkinson B, O’Connell M. Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis. Angewandte Chemie International Edition. 2022 Mar 24. doi: 10.1002/anie.202203175. Abstract
Schnegotzki R, Wiebach V, Sánchez-Hidalgo M, Tietzmann M, Zur Bonsen AB, Genilloud O, Süssmuth RD. Total Synthesis and Biosynthesis of Cyclodepsipeptide Cochinmicin I. Organic Letters. 2022 Mar 21. doi: 10.1021/acs.orglett.2c00525. Abstract
Pérez I, Campos-Pardos E, Díaz C, Uranga S, Sayes F, Vicente F, Aguiló N, Brosch R, Martín C, Gonzalo-Asensi J. The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy. Molecular Therapy: Nucleic Acids. 2022, Vol. 27 1235 – 1248. DOI: https://doi.org/10.1016/j.omtn.2022.02.011 Abstract
Castillo F, Corbi-Verge C, Murciano-Calles J, Candel A m, Han Z, Iglesias-Bexiga M, Ruiz-Sanz J, Kim P M, Harty R n, Martinez J C, Luque I. Phage display identification of nanomolar ligands for human NEDD4-WW3: Energetic and dynamic implications for the development of broad-spectrum antivirals. International Journal of Biological Macromolecules, 2022. Volume 207, 15 May 2022, Pages 308-323. DOI: https://doi.org/10.1016/j.ijbiomac.2022.03.010. Abstract
Georgousaki K, González-Menéndez V, Tormo JR, Tsafantakis N, Mackenzie TA,
Martín J, Gumeni S, Trougakos IP, Reyes F, Fokialakis N, Genilloud O. Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants. Scientifc Reports. 2022 Jan 31;12(1):1649. doi: 10.1038/s41598-022-05448-9. Abstract
Moo-Koh FA, Cristóbal-Alejo J, Andrés MF, Martín J, Reyes F, Tun-Suárez JM, Gamboa-Angulo M. In Vitro Assessment of Organic and Residual Fractions of Nematicidal Culture Filtrates from Thirteen Tropical Trichoderma Strains and Metabolic Profiles of Most-Active. Journal of Fungi (Basel). 2022 Jan 15;8(1):82. doi: 10.3390/jof8010082. Abstract
Wang X, Serrano R, González-Menéndez V, Mackenzie TA, Ramos MC, Frisvad JC, Larsen TO. A Molecular Networking Based Discovery of Diketopiperazine Heterodimers and Aspergillicins from Aspergillus caelatus. Journal of Natural Products. 2022 Jan 28;85(1):25-33. doi: 10.1021/acs.jnatprod.1c00526. Abstract
Miguel-Gordo M, Reddy MM, Sánchez P, Buckley JJ, Mackenzie TA, Jennings LK, Reyes F, Calabro K, Thomas OP. Antifungal mono- and dimeric nitrogenous bisabolene derivatives from a sponge in the order Bubarida from Futuna Islands. Organic & Biomolecular Chemistry. 2022 Jan 12. doi: 10.1039/d1ob02297k. Abstract
Parra-Millán R, Jiménez-Mejías ME, Ayerbe-Algaba R, Domínguez-Herrera J, Díaz C, Pérez Del Palacio J, Pachón J, Smani Y. Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy. Enfermedades infecciosas y microbiologia clinica (English ed.). 2022 Jan;40(1):14-21. doi: 10.1016/j.eimce.2020.06.019. Abstract
2021
Álvarez-Caballero JM, Cuca-Suárez LE, Coy-Barrera E, Carrasco-Pancorbo A, Olmo-García L, Martin J, Cruz M, Peŕez-Victoria I, Reyes F. Caerulines A and B, Flavonol Diacylglycosides from Persea caerulea. American Chemical Society Omega. 2021 Nov 23;6(48):32631-32636. doi: 10.1021/acsomega.1c04255. Abstract
Annang F, Pérez-Moreno G, Díaz C, González-Menéndez V, de Pedro Montejo N, Del Palacio JP, Sánchez P, Tanghe S, Rodriguez A, Pérez-Victoria I, Cantizani J, Ruiz-Pérez LM, Genilloud O, Reyes F, Vicente F, González-Pacanowska D. Preclinical evaluation of strasseriolides A-D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251. Malar J. 2021 Dec 5;20(1):457. doi: 10.1186/s12936-021-03993-8. Abstract
Sarmiento-Vizcaíno A, Martín J, Reyes F, García LA, Blanco G. Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain. Front Microbiol. 2021, 12:773095. Abstract
Beck C, Gren T, Ortiz-López FJ, Jørgensen T S, Carretero-Molina D, Martín Serrano J, Tormo JR, Oves-Costales D, Kontou E E, Mohite OS, Mingyar E, Stegmann E, Genilloud O, Weber T. Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods. Molecules 2021, 26, 6580. Abstract
Vitorino I, Santos JDN, Godinho O, Vicente F, Vasconcelos V, Lage OM. Novel and Conventional Isolation Techniques to Obtain Planctomycetes from Marine Environments. Microorganisms. 2021 Oct 1;9(10):2078. doi: 10.3390/microorganisms9102078. Abstract
Prado-Alonso L, Pérez-Victoria I, Malmierca MG, Montero I, Rioja-Blanco E, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Colibrimycins, novel halogenated hybrid PKS-NRPS compounds produced by Streptomyces sp. CS147. Appl Environ Microbiol. 2021 Oct 20:AEM0183921. doi: 10.1128/AEM.01839-21. Abstract
Oluwabusola ET, Adebisi OO, Reyes F, Acquah KS, De La Cruz M, Mweetwa LL, Rajakulendran JE, Warner DF, Hai D, Ebel R, Jaspars M. Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B. Beilstein J Org Chem. 2021 Sep 13;17:2390-2398.
doi: 10.3762/bjoc.17.156. Abstract
Díaz C, Jiménez-Luna C, Diéguez-Castillo C, Martín A, Prados J, Martín-Ruíz JL, Genilloud O, Vicente F, Pérez Del Palacio J, Caba O. Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis. Medicina (Kaunas). 2021 Aug 26;57(9):876. doi: 10.3390/medicina57090876. Abstract
Jørgensen TS, Gren T, Oves-Costales D, Ortiz-López FJ, Carretero-Molina D, González I, Blin K, Genilloud O, Weber T. Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a 35-Module Type I Polyketide Synthase. Microbiol Resour Announc. 2021 Sep 23;10(38):e0080521. doi: 10.1128/MRA.00805-21. Abstract
Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, Stadler M, Tormo JR, Genilloud O, Truman AW, Weissman KJ, Takano E, Sabatini S, Stegmann E, Brötz-Oesterhelt H, Wohlleben W, Seemann M, Empting M, Hirsch AKH, Loretz B, Lehr CM, Titz A, Herrmann J, Jaeger T, Alt S, Hesterkamp T, Winterhalter M, Schiefer A, Pfarr K, Hoerauf A, Graz H, Graz M, Lindvall M, Ramurthy S, Karlén A, van Dongen M, Petkovic H, Keller A, Peyrane F, Donadio S, Fraisse L, Piddock LJV, Gilbert IH, Moser HE, Müller R. Towards the sustainable discovery and development of new antibiotics. Nat Rev Chem. 2021 Aug 19:1-24. doi: 10.1038/s41570-021-00313-1. Abstract
Jørgensen TS, Gren T, Kontou EE, González I, Román-Hurtado F, Oves-Costales D, Thomsen E, Charusanti P, Genilloud O, Weber T. Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp. Strain CA-103260. Microbiol Resour Announc. 2021 Jul 29;10(30):e0049921. doi: 10.1128/MRA.00499-21. Abstract
Kontou EE, Gren T, Ortiz-López FJ, Thomsen E, Oves-Costales D, Díaz C, de la Cruz M, Jiang X, Jørgensen TS, Blin K, Charusanti P, Reyes F, Genilloud O, Weber T. Discovery and Characterization of Epemicins A and B, New 30-Membered Macrolides from Kutzneria sp. CA-103260. ACS Chem Biol. 16(8):1456-1468. doi: 10.1021/acschembio.1c00318. Abstract
Juhasz B, Pech-Puch D, Tabudravu JN, Cautain B, Reyes F, Jiménez C, Kyeremeh K, Jaspars M. Dermacozine N, the First Natural Linear Pentacyclic Oxazinophenazine with UV-Vis Absorption Maxima in the Near Infrared Region, along with Dermacozines O and P Isolated from the Mariana Trench Sediment Strain Dermacoccus abyssi MT 1.1 T. Mar Drugs. 2021 Jun 3;19(6):325. doi: 10.3390/md19060325. Abstract
Del Carratore F, Iorio M, Pérez-Bonilla M, Schmidt K, Pérez-Redondo R, Sosio M, Macdonald SJ, Gyulev IS, Tsigkinopoulou A, Thomas GH, Genilloud O, Rodríguez-García A, Donadio S, Breitling R, Takano E. Multi-omics Study of Planobispora rosea, Producer of the Thiopeptide Antibiotic GE2270A. mSystems. 6(3):e0034121. doi: 10.1128/mSystems.00341-21. Abstract
Serrano R, González-Menéndez V, Martínez G, Toro C, Martín J, Genilloud O, Tormo R. Metabolomic Analysis of The Chemical Diversity of South Africa Leaf Litter Fungal Species Using an Epigenetic Culture-Based Approach. Molecules. 2021; 26(14):4262. https://doi.org/10.3390/molecules26144262 Abstract
Beck C, Gren T, Jørgensen TS, González I, Román-Hurtado F, Oves-Costales D, Genilloud O, Weber T. Complete Genome Sequence of Streptomyces sp. Strain CA-256286. Microbiol Resour Announc. 2021 Jun 3;10(22):e0029021. doi:10.1128/MRA.00290-21. Abstract
Breitling R, Avbelj M, Bilyk O, Carratore FD, Filisetti A, Hanko EKR, Iorio M, Redondo RP, Reyes F, Rudden M, Severi E, Slemc L, Schmidt K, Whittall DR, Donadio S, García AR, Genilloud O, Kosec G, De Lucrezia D, Petković H, Thomas G,Takano E. Synthetic biology approaches to actinomycete strain improvement. FEMS Microbiol Lett. 2021 Jun 11;368(10): fnab060. doi: 10.1093/femsle/fnab060. Abstract
Navarro-Marchal SA, Griñán-Lisón C, Entrena JM, Ruiz-Alcalá G, Tristán-Manzano M, Martin F, Pérez-Victoria I, Peula-García JM, Marchal JA. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 2021 Apr 12;22(4):1374-1388. doi:10.1021/acs.biomac.0c01546. Abstract
Guevara L, Domínguez-Anaya MÁ, Ortigosa A, González-Gordo S, Díaz C, Vicente F, Corpas FJ, Pérez Del Palacio J, Palma JM. Identification of Compounds with Potential Therapeutic Uses from Sweet Pepper (Capsicum annuum L.) Fruits and Their Modulation by Nitric Oxide (NO). Int J Mol Sci. 2021 Apr 25;22(9):4476. doi: 10.3390/ijms22094476. Abstract
Guo Y, Ding L, Ghidinelli S, Gotfredsen CH, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Coriani S, Larsen RW, Frisvad JC, Larsen TO. Taxonomy Driven Discovery of Polyketides from Aspergillus californicus. J Nat Prod. 2021 Apr 23;84(4):979-985. doi: 10.1021/acs.jnatprod.0c00866. Abstract
Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López F J, Genilloud O. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs. Antibiotics, (2021), 403, 10(4) doi: 10.1101/2020.05.20.105809. Abstract
Cebrero-Cangueiro T, Labrador-Herrera G, Pascual Á, Díaz C, Rodríguez-Baño J, Pachón J, del Palacio JP, Pachón-Ibáñez ME and Conejo MC . Efficacy of Fosfomycin and Its Combination With Aminoglycosides in an Experimental Sepsis Model by Carbapenemase-Producing Klebsiella pneumoniae Clinical Strains. Front. Med. 8:615540. doi: 10.3389/fmed.2021.615540. Abstract
Carretero-Molina D, Ortiz-López FJ, Martín J, González I, Sánchez-Hidalgo M, Román-Hurtado F, Díaz C, de la Cruz M, Genilloud O, Reyes F. Pentaminomycins F and G, Nonribosomal Peptides Containing 2-Pyridylalanine. J Nat Prod. 2021 , 84, 4, 1127-1134. doi: 10.1021/acs.jnatprod.0c01199. Epub ahead of print. Abstract
Herath KB, Previs SF, Roddy TP, Attygalle AB, González I, Genilloud O, Singh SB. Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry. J Nat Prod. 2021 Mar 26;84(3):814-823. doi: 10.1021/acs.jnatprod.0c01190. Abstract
Navarro-Marchal SA, Griñán-Lisón C, Entrena JM, Ruiz-Alcalá G, Tristán- Manzano M, Martin F, Pérez-Victoria I, Peula-García JM, Marchal JA. Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells. Biomacromolecules. 2021 Apr 12;22(4):1374-1388. doi: 10.1021/acs.biomac.0c01546. Abstract
Fernández-Pastor, I.; González-Menéndez, V.; Annang, F.; Toro, C.; Mackenzie, T.A.; Bosch-Navarrete, C.; Genilloud, O.; Reyes, F. Pipecolisporin, a Novel Cyclic Peptide with Antimalarial and Antitrypanosome Activities from a Wheat Endophytic Nigrospora oryzae. Pharmaceuticals 2021, 14, 268. https://doi.org/10.3390/ph14030268, 14(3), 268; Abstract
Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, Gonzalez-Menendez V, Genilloud O, Trougakos IP, Fokialakis N, Ouazzani J. Elastase inhibitory activity of secondary metabolites from the fungus Virgaria nigra CF-231658. Nat Prod Res. 2021 Mar 11:1-4. doi: 10.1080/14786419.2021.1899175. Abstract
Rotter A, Barbier M, Bertoni F, Bones AM, Cancela ML, Carlsson J, Carvalho MF, Cegłowska M, Chirivella-Martorell J, Conk DM, Cueto M, Dailianis T, Deniz I, Díaz-Marrero AR, Drakulovic D, Dubnika A, Edwards C, Einarsson H, Erdoan A, Eroldoan OT, Ezra D, Fazi S, FitzGerald RJ, Gargan LM, Gaudêncio SP, Gligora UM, Ivosevic DeNardis N, Jónsdóttir R, Katarzytė M, Klun K, Kotta J, Ktari L, Ljubesic Z, Lukic Bilela L, Mandalakis M, Massa-Gallucci A, Matijosytė I, Mazur-Marzec H, Mehiri M, Nielsen Søren L, Novoveská L, Overlingė D, Perale G, Ramasamy P, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Röttinger E, Rudovica V, Sabotic J, Safarik I, Talve S, Tasdemir D, Theodotou Schneider X, Thomas OP, Toruńska-Sitarz A, Varese GC, Vasquez MI. The Essentials of Marine Biotechnology. Front. Mar. Sci., (2021), 158, 8. DOI:10.3389/fmars.2021.629629. Abstract
Silvestri A, Vicente F, Vicent MJ, Stechmann B, Fecke W. Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery. Drug Discov Today. (2021) 1369-1381, 26(6). doi: 10.1016/j.drudis.2021.02.024. Abstract
García-Padilla C, Lozano-Velasco E, López-Sánchez C, Garcia-Martínez V, Aranega A, Franco D. Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers. Noncoding RNA. 2021 Feb 17;7(1):13. doi: 10.3390/ncrna7010013. Abstract
Palacios-Ferrer JL, García-Ortega MB, Gallardo-Gómez M, García MÁ, Díaz C, Boulaiz H, Valdivia J, Jurado JM, Almazan-Fernandez FM, Arias-Santiago S, Amezcua V, Peinado H, Vicente F, Pérez Del Palacio J, Marchal JA. Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma.Mol Oncol. 2021 Feb;15(2):407-428. doi: 10.1002/1878-0261.12823. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. New naphthyl derivatives from Aspergillus californicus. J Antibiot. 74, 111–114 (2021). doi: 10.1038/s41429-020-00372-4. Abstract
Montalbán-López M, Scott TA, Ramesh S, Rahman IR, van Heel AJ, Viel JH, Bandarian V, Dittmann E, Genilloud O, Goto Y, Grande Burgos MJ, Hill C, Kim S, Koehnke J, Latham JA, Link AJ, Martínez B, Nair SK, Nicolet Y, Rebuffat S, Sahl HG, Sareen D, Schmidt EW, Schmitt L, Severinov K, Süssmuth RD, Truman AW, Wang H, Weng JK, van Wezel GP, Zhang Q, Zhong J, Piel J, Mitchell DA, Kuipers OP, van der Donk WA. New developments in RiPP discovery, enzymology and engineering. Nat. Prod. Rep., 2021,38, 130-239. doi: 10.1039/d0np00027b. Abstract
Gavriilidou, A.; Mackenzie, T.A.; Sánchez, P.; Tormo, J.R.; Ingham, C.; Smidt, H.; Sipkema, D. Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria. Mar. Drugs 2021, 19, 75. https://doi.org/10.3390/md19020075 Abstract
Subko K, Wang X, Nielsen FH, Isbrandt T, Gotfredsen CH, Ramos MC, Mackenzie T, Vicente F, Genilloud O, Frisvad JC, Larsen TO. Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility. Front Microbiol. 2021 Jan 15;11:618730. doi: 10.3389/fmicb.2020.618730. Abstract
Subko K, Kildgaard S, Vicente F, Reyes F, Genilloud O, Larsen TO. Bioactive Ascochlorin Analogues from the Marine-Derived Fungus Stilbella fimetaria. Mar Drugs. 2021 Jan 20; 19(2), 46. doi: 10.3390/md19020046. Abstract
Díaz-Beltrán L, González-Olmedo C, Luque-Caro N, Díaz C, Martín-Blázquez A, Fernández-Navarro M, Ortega-Granados AL, Gálvez-Montosa F, Vicente F, Pérez Del Palacio J, Sánchez-Rovira P. Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer. Cancers (Basel). 2021 Jan 5;13(1):147. doi:10.3390/cancers13010147. Abstract
Pérez-Victoria I. Co-occurring congeners reveal the position of enantiomeric amino acids in nonribosomal peptides. Chembiochem. 2021 Jan 13. doi: 10.1002/cbic.202000805. Abstract
Méndez-Luna D, Morelos-Garnica LA, García-Vázquez JB, Bello M, Padilla-Martínez II, Fragoso-Vázquez MJ, Dueñas González A, De Pedro N, Gómez-Vidal JA,Mendoza-Figueroa HL, Correa-Basurto J. Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells. Pharmaceuticals (Basel). 2021 Jan 10;14(1):49. doi: 10.3390/ph14010049. Abstract
Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López FJ, Carretero-Molina D, Reyes F, Genilloud O. One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360. Microorganisms. 2021 Jan 8;9(1):135. doi: 10.3390/microorganisms9010135. Abstract
Elamine Y, Lyoussi B, Miguel MG, Anjos O, Estevinho L, Alaiz M, Girón-Calle J, Martín J, Vioque J. Physicochemical characteristics and antiproliferative and antioxidant activities of Moroccan Zantaz honey rich in methyl syringate. Food Chem. 2021 Mar 1;339:128098. doi: 10.1016/j.foodchem.2020.128098. Abstract
2020
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. Oxepinamides L and M, two new oxepine-pyrimidinone-ketopiperazine type nonribosomal peptides from Aspergillus californicus. Nat Prod Res. 2020 Nov 9:1-6. doi: 10.1080/14786419.2020.1844699. Abstract
Jimenez-Luna C, Martin-Blazquez A, Dieguez-Castillo C, Diaz C, Martin-Ruiz JL, Genilloud O, Vicente F, Del Palacio JP, Prados J, Caba O. Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics. Metabolites. 2020 Oct 22;10(11):423. doi: 10.3390/metabo10110423. Abstract
Calabro K, Jennings LK, Lasserre P, Doohan R, Rodrigues D, Reyes F, Ramos C, Thomas OP. Nebulosins: Trisubstituted Thiolane Natural Products from the Northeastern Atlantic Annelid Eupolymnia nebulosa. J Org Chem. 2020, 85, 21, 14026–14041. Abstract
Jimenez-Luna C, Martin-Blazquez A, Dieguez-Castillo C, Diaz C, Martin-Ruiz JL, Genilloud O, Vicente F, Del Palacio JP, Prados J, Caba O. Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics. Metabolites. 2020 Oct 22;10(11):E423. Abstract
Cruz-Cerino P, Cristóbal-Alejo J, Ruiz-Carrera V, Carnevali G, Vera-Ku M, Martín J, Reyes F, Gamboa-Angulo M. Extracts from Six Native Plants of the Yucatán Peninsula Hinder Mycelial Growth of Fusarium equiseti and F. oxysporum, Pathogens of Capsicum chinense. Pathogens. 2020 Oct 10;9(10):E827. Abstract
Guo Y, Ghidinelli S, de la Cruz M, Mackenzie TA, Ramos MC, Sánchez P, Vicente F, Genilloud O, Larsen TO. New naphthyl derivatives from Aspergillus californicus. J Antibiot 74, 111–114 (2021). Abstract
Pérez-Bonilla M, Oves-Costales D, González I, de la Cruz M, Martín J, Vicente F, Genilloud O, Reyes F. Krisynomycins, Imipenem Potentiators against Methicillin-Resistant Staphylococcus aureus, Produced by Streptomyces canus. J Nat Prod. 2020, 83,9,2597-2606. Abstract
Annang F, Pérez-Moreno G, González-Menéndez V, Lacret R, Pérez-Victoria I,Martín J, Cantizani J, de Pedro N, Choquesillo-Lazarte D, Ruiz-Pérez LM,González-Pacanowska D, Genilloud O, Vicente F, Reyes F. Strasseriolides A-D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251. Org Lett. 2020, 22, 17, 6709–6713. Abstract
Bekiesch P, Zehl M, Domingo-Contreras E, Martín J, Pérez-Victoria I, Reyes F, Kaplan A, Rückert C, Busche T, Kalinowski J, Zotchev SB. Viennamycins: Lipopeptides Produced by a Streptomyces sp. J. Nat. Prod. 2020, 83, 8, 2381–2389. Abstract
Diogo Santos J, Vitorino I, Reyes F, Vicente F, Lage O M. From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria. Antibiotics 2020, 9(8), 455; Abstract
Oluwabusola ET, Tabudravu JN, Al Maqbali KS, Annang F, Pérez-Moreno G, Reyes F, Jaspars M. Antiparasitic activity of bromotyrosine alkaloids and new analogues isolated from the Fijian marine Sponge Aplysinella rhax. Chem Biodivers. 2020 Jul 22. doi: 10.1002/cbdv.202000335. Abstract
Parra-Millán R, Jiménez-Mejías ME, Ayerbe-Algaba R, Domínguez-Herrera J, Díaz C, Pérez Del Palacio J, Pachón J, Smani Y. Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy. Enferm Infecc Microbiol Clin. 2020 Jul 13:S0213-005X(20)30233-0. Abstract
Sánchez-Hidalgo M, Pascual J, González I, Genilloud O. Draft Genome Sequenceand Biosynthetic Potential of the Newly Described Strain Longimicrobium terrae CB-286315. Microbiol Resour Announc. 2020 Jun 11;9(24):e00512-20. Abstract
Tienaho J, Karonen M, Muilu-Mäkelä R, Kaseva J, de Pedro N, Vicente F,Genilloud O, Aapola U, Uusitalo H, Vuolteenaho K, Franzén R, Wähälä K, Karp M,Santala V, Sarjala T. Bioactive Properties of the Aqueous Extracts of Endophytic Fungi Associated with Scots Pine (Pinus sylvestris) Roots. Planta Med. 2020; 86(13/14): 1009-1024. Abstract
Román-Hurtado F, Sánchez-Hidalgo M, Martín J, Ortiz-López F J, Genilloud O. Biosynthesis and heterologous expression of cacaoidin, the first member of the lanthidin family of RiPPs. bioRxiv. doi: 10.1101/2020.05.20.105809. Abstract
Ortiz-López FJ, Carretero-Molina D, Sánchez-Hidalgo M, Martín J, González I, Román-Hurtado F, De la Cruz M, García-Fernández S, Reyes F, Deisinger JP, Müller A, Schneider T & Genilloud O. Cacaoidin, First Member of the New Lanthidin RiPP Family. Angewandte Chemie International Edition 2020; doi.org/10.1002/anie.202005187. Abstract
Becerril A, Pérez-Victoria I, Ye S, Braña AF,Martín J, Reyes F, Salas JA, and Méndez C. Discovery of Cryptic Largimycins in Streptomyces Reveals Novel Biosynthetic Avenues Enriching the Structural Diversity of the Leinamycin Family. ACS Chem. Biol. 2020, 15, 6, 1541–1553; Abstract
Corpas-López V, Tabraue-Chávez M, Sixto-López Y, Panadero-Fajardo S, Alves de Lima Franco F, Domínguez-Seglar JF, Morillas-Márquez F, Franco-Montalbán F, Díaz-Gavilán M, Correa-Basurto J, López-Viota J, López-Viota M, Pérez Del Palacio J, de la Cruz M, de Pedro N, Martín-Sánchez J, Gómez-Vidal JA. O-Alkyl Hydroxamates Display Potent and Selective Antileishmanial Activity. J Med Chem. 2020 Jun 11;63(11):5734-5751.
Abstract
Crespo G, Pérez-Victoria I, Ortiz-López FJ, González-Menéndez V, De la Cruz M, Cautain B, Sánchez P, Vicente F, Genilloud O and Reyes F. Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus Foliophoma fallens. Antibiotics 2020, 9(6), 278. Abstract
Cabello-Donayre M, Orrego LM, Herráez E, Vargas P, Martínez-García M, Campos-Salinas J, Pérez-Victoria I, Vicente B, Marín JJG, Pérez-Victoria JM. Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite. Cell. Mol. Life Sci., 77, pages1827–1845(2020). Abstract
Rotter A, Bacu A, Barbier M, Bertoni F, Bones A M, Cancela M L, Carlsson J, Carvalho M F, Cegłowska M, Dalay M C, Dailianis T, Deniz I, Drakulovic D, Dubnika A, Einarsson H, Erdoğan A, Eroldoğan O T, Ezra D, Fazi S,FitzGerald R J, Gargan L M, Gaudêncio S P, DeNardis N I, Joksimovic D, Kataržytė M, Kotta J, Mandalakis M, Matijošytė I, Mazur-Marzec H, Massa-Gallucci A, Mehiri M, Nielsen S L, Novoveská L, Overlingė D, Portman M E, Pyrc K, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Rudovica V, Sabotič J, Safarik I, Talve S, Tasdemir D, Schneider X T, Thomas OP, Toruńska-Sitarz A, Varese G C, Vasquez . A new network for the advancement of marine biotechnology in Europe and beyond. Front. Mar. Sci., 2020; 7:278. Abstract
Martín-Blázquez A, Jiménez-Luna C,Díaz C, Martínez-Galán J, Prados J, Vicente F, Melguizo C, Genilloud O, Pérez del Palacio J, Caba O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers, 2020, 12(4), 1002. Abstract
Berenguel Hernández A M., De la Cruz M, Alcázar-Fabra M, Prieto-Rodríguez A, Sánchez-Cuesta A, Martin J, Tormo J R, Rodríguez-Aguilera J C, Cortés-Rodríguez A B, Navas P, Reyes F, Vicente F, Genilloud O, Santos-Ocaña C. Design of high-throughput screening of natural extracts to identify molecules bypassing primary coenzyme Q deficiency in Saccharomyces cerevisiae. SLAS Discov., 2020, 25, 299-309. Abstract
Salamanca-Fernández E,Rodríguez-Barranco M, Arrebola JP, Vela F, Díaz C, Chirlaque M D, Colorado-Yohar S, Jiménez-Zabala A, Irizar A, Guevara M, Ardanaz E, Iribarne-Durán LM, Pérez del Palacio J, Olea N, Agudo A, Sánchez MJ. Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors. Environmental Research,2020, 182, 109012. Abstract
Lauritano C, Martínez K A, Battaglia P, Granata A, De la Cruz M, Cautain B, Martín J, Reyes F, Ianora A, Guglielmo L. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Sci Rep., 10, 4929 (2020). Abstract
Diogo Santos J, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez I, Tormo J R, Martin J, Vicente MF, Lage OM. Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges. Antonie van Leeuwenhoek, 113, pages875–887(2020). Abstract
Sánchez-Hidalgo M, Martín J, Genilloud O. Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator. Antibiotics, 2020, 9(2), 67. Abstract
Georgousaki K, Tsafantakis N, Gumeni S, Lambrinidis G, González-Menéndez V, Tormo JR, Genilloud O, Trougakos IP, Fokialakis N. Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules. Molecules, 2020, 25(3), 666. Abstract
Fang Q , Maglangit F , Wu L, Ebel R, Kyeremeh K, Andersen JH, Annang F, Pérez-Moreno G,Reyes F, Deng H. Signalling and Bioactive Metabolites from Streptomyces sp. RK44, Molecules, 2020, 25(3), 460. Abstract
Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Generation of new sipanmycin analogues by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway. Appl. Environ. Microbiol., 2020, 86, e02453-19. Abstract
Georgousaki, K., Tsafantakis, N., Gumeni, S., Gonzalez, I., Andrew Mackenzie, T., Reyes F., Lambert, C., Trougakos, I.P., Genilloud, O., Fokialakis, N., Screening for tyrosinase inhibitors from actinomycetes; Identification of trichostatin derivatives from Streptomyces sp. CA-129531 and scale up production in bioreactor. Bioorg Med Chem Lett., 2020, 15;30(6):126952. Abstract
Romain Koagne R, Annang F, Cautain B, Martín J, Pérez-Moreno G, Thierry M. Bitchagno G, González-Pacanowska D, Vicente F, Konga Simo I, Reyes F & Tane P. Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae). BMC Complementary Medicine and Therapies, 2020,15;20(1):8. Abstract
Carretero-Molina D, Ortiz-López F J, Martín J, Oves-Costales D, Díaz C, De la Cruz M, Cautain B, Vicente F, Genilloud O, Reyes F. New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078. Mar. Drugs, 2020, 18(1), 22. Abstract
Mazzotta S, Marrugal-Lorenzo J A, Vega-Holm M, Serna-Gallego A, Álvarez-Vidal J, Berastegui-Cabrera J, Pérez del Palacio J, Díaz C, Aiello F, Pachón J,Iglesias-Guerra F,Vega-Pérez J M, Sánchez-Céspedes J. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents. Eur J Med Chem., 2020, 1;185. Abstract
2019
Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer. Sci Rep., 9, 20198 (2019). Abstract
Almeida C, Mackenzie TA, González-Menendez V, De Pedro N, Pérez-Victoria I, Crespo G, Martín J, Genilloud O, Vicente F, Cautain B, Reyes F. Laccaridione C, a Bioactive Polyketide from the Fungus Montagnula sp. PMIO, 2019; 6(02): e57-e62. Abstract
Barúa JE, De la Cruz M, De Pedro N, Cautain B, Hermosa R, Cardoza RE, Gutiérrez S, Monte E, Vicente F, Collado IG. Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities. Molecules, 2019, 24, 3811 Abstract
Tejman-Yarden N, Robinson A, Davidov Y, Shulman A, Varvak A, Reyes F, Rahav G, Nissan I. Delftibactin-A, a Non Ribosomal Peptide with Broad Antimicrobial Activity. Front. Microbiol., 10:2377 doi: 10.3389/fmicb.2019.02377. Abstract
Reina JC, Pérez-Victoria I, Martín J, Llamas I. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar. Drugs, 2019, 17: 494. Abstract
González-Menéndez V, Crespo G, Toro C, Martín J, de Pedro N, Tormo JR, Genilloud O. Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani. Metabolites, 2019, 9: 197. Abstract
Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, González I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J. Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. Molecules, 2019, 24: 2239. Abstract
Peyrat L-A, Tsafantakis N, Georgousaki K, Ouazzani J, Genilloud O, Trougakos IP, Fokialakis N. Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications. Molecules, 2019, 24: 1836. Abstract
Georgousaki K, Tsafantakis N, Gumeni S, González-Menéndez V, de Pedro N, Tormo JR, Almeida C, Lambert C, Genilloud O, Trougakos IP, Fokialakis N. Cercospora sp. as a source of anti-aging polyketides targeting 26S proteasome and scale-up production in submerged bioreactor. J Biotechnol., 2019, 301: 88-96. Abstract
Martínez KA, Lauritano C, Druka D, Romano G, Grohmann T, Jaspars M, Martín J, Díaz C, Cautain B, de la Cruz M, Ianora A, Reyes F. Amphidinol 22, a new cytotoxic and antifungal amphidinol from the dinoflagellate Amphidinium carterae. Mar. Drugs, 2019, 17: 385. Abstract
Díaz C, Pérez del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J. Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate. ACS Infectious Diseases., 2019, 5: 1317-1326. Abstract
Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez Martinez I, Tormo JR, Martín JM, Urbatzka R, Vicente FM, Lage OM. Bioactivities and Extract Dereplication of Actinomycetales isolated from Marine Sponges. Front Microbiol., 2019, 10: 727. Abstract
Pérez del Palacio J, Díaz-Navarro C, Martín-Blázquez A, González-Olmedo C, Vergara-Segura N, Algieri F, Rodriguez-Nogales A, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, Rodríguez-Cabez MA. Metabolomic analysis of Lavandula dentata L. and Lavandula stoechas L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool. Plant. Biosyst., 2019, 154:231-240. Abstract
Butassi E, Svetaz LA, Zhou S, Wolfender JL, G. Cortés JC, Ribas JC, Díaz-Navarro C, Pérez del Palacio J, Vicente F, Zacchino SA. The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera. Phytomedicine, 2019, 60: 152884. Abstract
Martín J, Reyes F, Vicente F, Gamboa-Angulo M, Escalante-Réndiz D, De la Rosa García S, Tapia-Tussell R. Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity. Int J. Environ. Res. Public Health, 2019, 16: 1913. Abstract
Khentoul H, Bensouici C, Reyes F, Albanese D, Sarri D, Mekkiou R, Benayache F, Seghiri R, Boumaza O. Chemical constituents and HRESI-MS analysis of an Algerian endemic plant-Verbascum atlanticum Batt.- extracts and their antioxidant activity. Nat. Prod. Res., 2019, 22: 1-5. Abstract
Guillen PO, Jaramillo KB, Jennings L, de la Cruz M, Cautain B, Reye Fs, Rodríguez J, Thomas OP. Halogenated tyrosine derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini. J. Nat. Prod., 2019, 82: 1354-1360. Abstract
Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P. Activation of secondary metabolite gene clusters in Streptomyces clavuligerus by the PimM regulator of Streptomyces natalensis. Front. Microbiol., 2019, 10: 580. Abstract
Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Caniferolide A, a macrolide from Streptomyces caniferus, attenuates neuroinflammation, oxidative stress, amyloid-beta and tau pathology in vitro. Mol. Pharm., 2019, 16: 1456-1466. Abstract
Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Diaz C, Cautain B, Vicente F, Genilloud O, Reyes F. Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive glycosylated 36-membered polyol macrolides from the marine-derived Streptomyces caniferus CA-271066. Org. Biomol. Chem., 2019, 17:2954-2971. Abstract
Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Gloria Blanco. Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. Mar. Drugs, 2019, 17 (2) : 114. Abstract
Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P, Simova S, Les´nikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, and Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discover., 2019, 24: 398-413. Abstract
Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2019, 33: 66-73 Abstract
Castillo F., Mackenzie T.A., Cautain B. Immunofluorescence Analysis by Confocal Microscopy for Detecting Endogenous FOXO. Link W. (eds) FOXO Transcription Factors. Methods in Molecular Biology, 2019, 1890: 143-149. Abstract
2018
Koagne RR, Annang F, de la Cruz M, Bitchagno GTM, Perez-Victoria I, Konga IS, Vicente F, Reyes F, Tane P. Antibacterial Activity of Flavans from Crinum distichum. Natural Product Communications 2018, 13 : 637-1638. Abstract
Genilloud O. Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm? Antibiotics, 2018, 7: 85. Abstract
Calabro K, Chalén BE, Genta-Jouve G, Jaramillo KB, Domínguez C, de la Cruz M, Cautain B, Reyes F, Thomas OP, Rodríguez J. Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californica. J. Nat. Prod., 2018, 81, 2301-2305. Abstract
Rodríguez V, J. Martín, A. Sarmiento-Vizcaíno, M. de la Cruz, L. A. García, G. Blanco, Reyes F. Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169. Mar. Drugs, 2018, 16: 406. Full text
Ortiz-López FJ, Alcalde E, Sarmiento-Vizcaíno A, Díaz C, Cautain B, García, Blanco G, Reyes F. New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157. Mar. Drugs, 2018, 16: 371. Abstract
Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Streptocyclinones A and B ameliorate Alzheimer’s disease pathological processes in vitro. Neuropharmacology, 2018, 141: 283-295. Abstract
Solanki H, Angulo-Preckler C, Calabro K, Kaur N, Lasserre P, Cautain B, de la Cruz M, Reyes F, Avila C, Thomas OP. Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905). Tetrahedron Lett., 2018, 59: 3353-3356. Abstract
Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353. J. Nat. Prod., 2018, 81: 1687-1691. Abstract
Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Olano C, Salas JA, Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149. Appl Environ Microbiol 84:e01462-18. Abstract
Li F, Janussen D, Peifer C, Pérez-Victoria I, Tasdemir D, Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity. Mar. Drugs 2018, 16, 268. Abstract
Lage OM, Ramos MC, Calisto R, Almeida E, Vasconcelos V, Vicente F. Current Screening Methodologies in Drug Discovery for Selected Human Diseases. Marine Drugs. 2018; 16(8):279. Full article
Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo-Contreras E, Martín J, Machenzie T, Ruiz-Pérez L, González-Packanowska D, Genilloud O, Vicente F, Agyare C, Reyes F. Bioassay-guided isolation of four new antiprotozoal compounds from two Ghanaian mushrooms. Fitoterapia 2018 Jun, 127:341-348. Abstract
González-Menéndez V, Crespo G, De Pedro N, Diaz C, Martín J, Serrano R, Mackenzie TA, Justicia C, González-Tejero MR, Casares M, Vicente F, Reyes F, Tormo JR, Genilloud O. Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents. Nature.com, Scientific Reports, 2018, 8: 9729. Abstract
Almeida C, Silva Pereira C, González-Menéndez V, Bills G, Pascual J, Sánchez-Hidalgo M, Kehraus S, Genilloud O. Unveiling concealed functions of endosymbiotic bacteria harboured in the Ascomycota Stachylidium bicolor. Appl. Environ. Microbiol., 2018, DOI: 10.1128/AEM.00660-18. Abstract
Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O. Non-geminal aliphatic dihalogenation pattern in dichlorinated diaporthins from Hamigera fusca NRRL 35721. J. Nat. Prod., 2018, 81, 6, 1488–1492. Abstract
Sarmiento-Vizcaíno A, Espadas J, Martín J, Braña AF, Reyes F, García LA, Blanco G. Atmospheric precipitations, hailstone and rainwater, as a novel source of Streptomyces producing bioactive natural products. Front. Microbiol., 2018, 9:773. Abstract
Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Natural product Research, 2018, https://doi.org/10.1080/14786419.2018.1434636. Abstract
Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, Díaz-Navarro C, Pérez-Del Palacio J, García-Fernández M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla-Ortega E. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018 May 1;133:189-201. Abstract
Pachón-Ibáñez ME, Labrador-Herrera G, Cebrero-Cangueiro T, Díaz C, Smani Y, del Palacio JP, Rodríguez-Baño J, Pascual A, Pachón J and Conejo MC. Efficacy of Colistin and Its Combination with Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. Front. Microbiol 2018. 9:912. Abstract
Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N, Vallorani R, Diaz C, Pérez del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM. Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A, ACS Chem. Neurosci. 2018 DOI: 10.1021/acschemneuro.8b00060. Abstract
Ramos MC, Genilloud O, Reyes F, Vicente F. Drug Discovery from Natural Products for Pancreatic Cancer. Pancreatic Cancer Book. Intech, 2018. DOI: 10.5772/intechopen.76399 Abstract
Sánchez M, González I, Díaz C, Martínez G and Genilloud O. Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains. Front. Microbiol. 2018, 9:369. doi: 10.3389/fmicb.2018.00369. Abstract
Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2018, DOI:10.1080/14786419.2018.1434636. Abstract
Lauritano C, Martín J, de la Cruz M, Reyes F, Romano G, Ianora A. First identification of marine diatoms with anti-tuberculosis activity. Sci. Rep., 2018, 8:2284. Abstract
Sánchez L, Ladrón de Guevara D, Mañas MC, Alén F, Moreno RD, Díaz C, Perez del Palacio J, García M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla E, Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology (2018), doi: 10.1016/j.neuropharm.2018.01.033. Abstract
Pérez-Bonilla M, Oves-Costales D, de la Cruz M, Kokkini M, Martín J, Vicente F, Genilloud O and Reyes F. Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp. Mar. Drugs 2018, 16(3), 95; doi:10.3390/md16030095. Abstract
Castillo F, Mackenzie TA, Cautain B. Immunofluorescence analysis by confocal microscopy for detecting endogenous FOXO. Methods in Molecular Biology, DOI 10.1007/978-1.
Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA. Searching for glycosylated natural products in actinomycetes and identification of novel macrolactams and angucyclines. Front. Microbiol., 2018, 9:39. Abstract
2017
Firsova D, Calabro K, Lasserre P, Reyes F, Thomas OP. Isoguanosine Derivatives from the Northeastern Atlantic Sponge Clathria (Microciona) strepsitoxa. Tetrahedron Lett., 2017, 58:4652-4654. Abstract
Genilloud O. Actinomycetes: still a source of novel antibiotics. Nat. Prod. Rep., 2017,34, 1203-1232, 10.1039/C7NP00026J. Abstract
Genilloud O, Industrial Culture Collections: Gateways from Microbial Diversity to Applications in Microbial Resources: From Functional Existence in Nature to Applications, Ed J. Wink, 2017, Academic Press 237-256.
Ilic J, Cosic J, Vrandecic K, Dugalic K, Pranjic A, Martin J. Influence of endophytic fungi isolated from symptomless weeds on cherry plants. Mycosphere 2017: 8, 18-30. Full article
Peláez F, de Pedro N, Tormo JR. Chapter 9 of the book: Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Toxicological Implications, in Natural Products Targeting Clinically Relevant Enzymes (eds P. B. Andrade, P. Valentão and D. M. Pereira), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2017, Germany. doi: 10.1002/9783527805921
Braña AF, Sarmiento-Vizcaíno A, Osset M, Pérez-Victoria I, Martín J, de Pedro N, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa. Mar. Drugs, 2017, 15:144. Abstract
Calabro K, Kalahroodi EL, Rodrigues D, Díaz C, Cruz M, Cautain B, Laville R, Reyes F, Pérez T, Soussi B, Thomas OP. Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866). Mar Drugs, Jun 15:199, doi: 10.3390/md15070199. Abstract
Pascual J, García-López M, González I, Genilloud O. Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers. International Journal of Systematic and Evolutionary Microbiology, Sept. 67(10), DOI:10.1099/ijsem.0.002227. Abstract
Martínez G, González-Menéndez V, Martín J, Reyes F, Genilloud O, Tormo JR. MASS Studio: A Novel Software Utility to Simplify LC-MS Analyses of Large Sets of Samples for Metabolomics. In: Rojas I., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science, vol 10208. Springer, Cham. Abstract
Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Correction for Bertoni-Mann et al., “Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum CF-295141, Isolated from Pinus sylvestris ”. Genome Announcements 2017, 5(43):e01116-17., DOI:10.1128/genomeA.01116-17. Abstract
Almeida C, Bills G, González-Menéndez V, Martin J, Tormo JR, Genilloud O. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04. Fermentation 2017, 3(3):45., DOI:10.3390/fermentation3030045. Full paper
Boulaiz H, Ramos MC, Griñán-Lisón C, García-Rubiño ME, Vicente F, Marchal JA, What’s new in the diagnosis of pancreatic cancer: a patent review (2011-present), Expert Opinion. Expert Opin Ther Pat. 2017, Sept 10: 1-16. Full paper
Gonzalez-Menendez V, Martin J, Siles JA, Gonzalez-Tejero MR, Reyes F, Platas G, Tormo JR, Genilloud O. Biodiversity and chemotaxonomy of Preussia isolates from the Iberian Peninsula. Mycol Progress 2017, Vol.16, 7:713 – 728. Full paper
Ramos MC, Boulaiz H, Griñan-Lison C, Marchal JA, Vicente F. What’s new in treatment of pancreatic cancer: a patent review (2010-2017). Expert Opin Ther Pat. 2017, Jul 12:1-16, Full paper
Serrano R, González V, Rodríguez L, Martín J, Tormo JR, Genilloud O. Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents. Front. Microbiol., 2017, 649, Full paper
Pérez-del Palacio J, Díaz C, Vergara N, Algieri F, Rodríguez-Nogales A, de Pedro N, Rodríguez-Cabezas ME, Genilloud O, Gálvez J, Vicente F. Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. Front. Pharmacol, 2017, Full paper
Sonnenschein EC, Stierhof M, Goralczyk S, Vabre FM, Pellissier L, Hanssen KE, de la Cruz M, Díaz C, de Witte P, Copmans D, Andersen JH, Hansen E, Kristoffersen V, Tormo JR, Ebel R, Milne BF, Deng H, Gram L, Jaspars M, Tabudravu JN. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron, 2017, Chemical Engineering Journal, 2017, 320: 151-159. Abstract
Vela-Soria F, Gallardo Torres ME, Ballesteros O, Diaz C, Perez J, Navalón A, Fernandez MF, Olea N. Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Cromatography A, 2017, 1487: 153-161. Abstract
Borges-Argáez R, Cáceres-Farfán M, De Pedro N, Cautain B, Pérez del Palacio P, Vicente F, Genilloud O, Melguizo A, Díaz C, Reyes F, El Aouad N, Sansores-Peraza P. Cytotoxic studies and in vitro effects oftrans -3,4,4’,5-Tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth. Polibotanica, 2017, 43: 165-175. Full paper
Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, De Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MJ, Vicente F, Genilloud O, Tormo JR, Reyes F. Hormonemate Derivatives from the Endophytic Fungus Dothiora sp. J. Nat. Prod., 2017, DOI: 10.1021/acs.jnatprod.6b00680. Full paper
Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina sp. Planta Med., 2017, 05: 366-491. Abstract
Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, De la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Branimycins B and C, Antibiotics Produced by the abyssal Actinobacterium Pseudonocardia carboxydivorans M-227. J. Nat. Prod., 2017, 80: 569-573. Abstract
De la Cruz M, González I, Parish C, Onishi R, Tormo JR, Martín J, Peláez F, Zink D, El Aouad N, Reyes F, Genilloud O, Vicente F. Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes. Front. Microbiol., 2017, 8:343. Fullpaper
Paytubi S, De la Cruz M, Tormo JR, Martín J, González I, González-Menéndez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C. Microbial Natural Products High-Throughput Screening Platform for the Discovery of Molecules with Antibiofilm Properties Against Salmonella. Front. Microbiol., 2017, 8: 326. Fullpaper
González A, Gálvez N, Martín J, Reyes F, Pérez-Victoria I, Dominguez-Vera JM. Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption. Food Chem., 2017, 228: 374-380. Abstract
2016
Trabelsi I, Oves D, Manteca A, Genilloud O, Altalhi A, Nour M. Antimicrobial Activities of Some Actinomycetes Isolated from Different Rhizospheric Soils in Tunisia. Current Microbiology 2016, 73:220-227. Abstract
Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodríguez Quesada L, Machado L, Vicente F, Dallavalle S, Link W. Discovery of a Novel Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS ONE 2016, 11: e0167491. Abstract
Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Draft Genome Sequence of Phytopathogenic Fungus Fusarium fujikuroi CF-295141, Isolated from Pinus sylvestris. Genome Annoucements 2016, 4: e01163-16. Abstract
Lacret R, Pérez-Victoria I, Oves-Costales D, de la Cruz M, Domingo E, Martín J, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0170, a new napyradiomycin from Streptomyces sp. strain CA-271078. Mar. Drugs 2016, 14: 188. Abstract
Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina sp. Planta Med. 2016, 81(S01): S1-S381. Abstract
Stierhof M, Hansen KO, Sharma M, Feussner K, Subko K, Fernandez Díaz-Rullo F, Isaksson J, Pérez-Victoria I, Clarke D, Hansen E, Jaspars M, Tabudravu JN. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp. Tetrahedron 2016, 72: 6929-6934. Abstract
Angulo-Preckler C, Genta-Jouve G, Mahajan N, de la Cruz M, de Pedro N, Reyes F, Iken K, Avila C, Thomas OP. Gersemiols A-C and Eunicellol A, Diterpenoids from the Arctic Soft coral Gersemia fruticosa. J. Nat. Prod. 2016, 79: 1132-1136. Abstract
Pascual J, González I, Estévez M, Benito P, Trujillo ME, Genilloud O. Description of Kibdelosporangium banguiense sp. nov., a novel actinomycete isolated from soil of the forest of Pama, on the plateau of Bangui, Central African Republic. Antoine van Leeuwenhoek 2016, 109: 685-695. Abstract
Pascual J, García-López M, Bills GF, Genilloud O. Longimicrobium terrae gen. nov., sp. nov., a novel oligotrophic bacterium of the underrepresented phylum Gemmatimonadetes isolated through a system of miniaturized diffusion chambers. Int. J. Syst. Evol. Microbiol. 2016, 66: 1976-85. Abstract
García-Fontana B, Morale-Santana S, Díaz Navarro C, Rozas-Moreno P, Genilloud O, Vicente Pérez F, Pérez del Palacio J, Muñoz-Torres M. Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study. Talanta 2016, 148: 135-143. Abstract
Sekurova ON, Pérez-Victoria I, Martin J, Degnes KF, Sletta H, Reyes F, Zotchev SB, New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07, Molecules 2016, 21(9): 1131. Abstract
De Pedro N, Cautain B, Cantizani J, Rodriguez L, Vicente F, Tualsi R and Rao Koyyalamudi S. In vitro Neuroprotective Effects of Seven Natural products Against Rotenone-Induced Toxicity in a SH-SY5Y Neuroblastoma Cells Model for Parkinson’s Disease. Pharmacologia 2016, 7: 361-370. Full paper
Vela-Soria I, Jiménez-DíazC, Díaz J, Pérez LM, Iribarne-Durán L, Serrano-López JP, Arrebola1 MF, Fernández N, Olea. Determination of endocrine disrupting chemicals in human milk by dispersive liquid-liquid microextraction. Bioanalysis 2016, 17: 1777-91. Abstract
Algieri F, Rodriguez-Nogales A, Vezza T, Garrido-Mesa J, Garrido-Mesa N, Utrilla MP, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, del Mar Contreras M, Segura-Carretero A, Pérez-Palacio J, Diaz C, Vergara N, Vicente F, Rodriguez-Cabezas ME, Galvez J: Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L. J Ethnopharmacol 2016, 190: 142–158. Abstract
Annang F, Genilloud O, Vicente F. Contribution of Natural Products to Drug Discovery in Tropical Diseases. Chapter · July 2016, In book: Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, 75-104
Vicente F, Reyes F, Genilloud O. Fungal secondary metabolites as source of antifungal compounds. In Fungi: Applications and their Management Strategies. Sunil K. Deshmukh, J. K. Misra, Jalpa P. Tewari, Tamas Papp Eds., CRC Press, 2016. ISBN: 9781498724913, 80-116. Summary
Gonzalez-Menéndez V, Pérez-Bonilla M, Pérez-Victoria I, Martín J, Muñoz F, Reyes F, Tormo JR, Genilloud O. Multicomponent analysis of the differential induction of secondary metabolite profiles in fungal endophytes. Molecules 2016, 21(2): 234 Full paper
Pérez del Palacio I, Díaz C, De la Cruz M, Annang F, Martín J, Pérez-Victoria I, González-Menéndez V, De Pedro N, Tormo JR, Algieri F, Rodriguez-Nogales A, Rodríguez-Cabezas ME, Reyes F, Genilloud O, Vicente F, Gálvez J. High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries. J. Biomol. Screen. 2016, 21(6): 567-78. Abstract
Pérez-Victoria I, Martín J, Reyes F. Combined LC/UV/MS and NMR strategies for the dereplication of marine natural products. Planta Med 2016, 82: 857–871. Full paper
De Pedro N, Cantizani J, Ortiz-López FJ, González-Menéndez V, Cautain B, Rodríguez L, Bills GF, Reyes F, Genilloud O and Vicente F. Protective Effects of Isolecanoric Acid on Neurodegenerative Diseases. Neuropharmacology, 2016, 101: 538-548. Abstract
Pérez-Moreno G, Cantizani J, Sánchez-Carrasco P, Ruiz-Pérez LM, Martín J, El Aouad N, Pérez-Victoria I, Tormo JR, González V, González I, De Pedro N, Reyes F, Genilloud O, Vicente F, González-Pacanowska D. Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products. PLoS ONE 2016, 11(1): e0145812 Abstract
Jaspars, De Pascale D, Andersen JH, Reyes F, Crawford AD, Iannora A. The Marine Biodiscovery Pipeline and Ocean Medicines of Tomorrow. J. Mar. Biol. Assoc. U.K. 2016, 96: 151-158. Full paper
Pascual J, Blanco S, García-López M, García-Salamanca A, Bursakov SA, Genilloud O, Bills OF, Ramos JL, van Dillewijn P. Assessing Bacterial Diversity in the Rhizosphere of Thymus zygis Growing in the Sierra Nevada National Park (Spain) through Culture-Dependent and Independent Approaches. PLoS ONE 2016, 11: e0146558. Abstract
Parra Millán R, Jiménez Mejías ME, Sánchez Encinales V, Ayerbe Algaba R, Gutiérrez Valencia A, Pachón Ibáñez ME, Díaz C, Pérez del Palacio J, López Cortés LF, Pachón J, Smani Y. Efficacy of Lysophosphatidylcholine in Combination with Antimicrobial Agents against Acinetobacter baumannii in Experimental Murine Peritoneal Sepsis and Pneumonia Models. Antimicrob Agents Chemother 2016, 60: 4464–4470.2. Abstract
Fernández-Cruz ML, Martín-Cabrejas I, Pérez-del Palacio J, Gaya P, Díaz-Navarro C, Navas JM, Medina M, Arqués JL. In vitro toxicity of reuterin, a potential food biopreservative. Food Chem Toxicol 2016, 96: 155–159.5. Abstract
Ríos Peces S, Díaz Navarro C, Márquez López C, Caba O, Jiménez-Luna C, Melguizo C, Prados JC, Genilloud O, Vicente Pérez F, Pérez del Palacio J. Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma. J Biomol Screen 2016: 1087057116671490.8. Abstract
N’Ait Ousidi A, Ait Itto MY, Auhmani A, Barakate M, Riahi A, Ben El Ayouchia H, Anane H, El Aouad N, De La Cruz M, Díaz C, Vicente F. Synthesis, theoretical and biological studies of some novel Monoterpenic thiazolidin-4-ones. IOSR Journal of Applied Chemistry. Volume 9, Issue 11 Ver. II 2016, 52-61. Full paper
2015
Painter RE, Adam GC, Arocho M, DiNunzio E, Donald RG, Dorso K, Genilloud O, Gill C, Goetz M, Hairston NN,Murgolo N, Nare B, Olsen D.B, Powles M, Racine F, Su J, Vicente F, Wisniewski D, Xiao L, Hammond M, Young K. Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin. Chem Biol. 2015, 22(10): 1362-73. Abstract
Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, De Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA. Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010). Antimicrob Agents Chemother. 2015, 59 (9):5145-53. Full paper
Muñoz-Sáeza E, De Munck Garcíab S, Arahuetes Porterob RM, Vicente F, Ortiz-López FJ, Cantizani J, Gómez Miguel B. Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). Neuroscience Letters 2015, 593: 83–89. Abstract
Molina-Santiago C, Udaondo Z, Daddaoua A, Roca A, Martín J, Pérez-Victoria I, Reyes F, Ramos JL. Efflux pump deficient mutants as a platform to search for microbes that produce antibiotics. Microb. Biotechnol. 2015, 8: 716-725. Abstract
Tormo JR, Oves D, Lacret D, Moreno C, DeLa Cruz M, Díaz C, González I, Martín J, Pérez-Victoria, Vicente F, Reyes F, Genilloud O. Marine natural products drug discovery from actinomycetes at Fundacion MEDINA. Planta Medica 2015, 81:11. Abstract
Cautain B, De Pedro N, Schulz C, Pascual J, Sousa TS, Martin J, Pérez-Victoria I, Asensio F, González I, Bills G.F, Reyes F, Genilloud O, Vicente F Identification of the lipodepsipeptide MDN-0066, a novel inhibitor of VHL/HIF pathway produced by a new Pseudomonas species. PLOS ONE 2015, 10(5): e0125221 Abstract
Figueroa L, Jiménez C, Rodríguez J, Areche C, Chávez R, Heríquez M, De la Cruz M, Díaz C, Segade Y, Vaca I. 3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus. J. Nat Prod. 2015, 78 (4): 919–923 – Abstract
Ortiz-López FJ, Monteiro MC, González-Menéndez V, Tormo JR, Genilloud O, Bills GF, Vicente F, Zhang C, Roemer T, Singh SB, Reyes F. Cyclic Colisporifungin and Linear Cavinafungins, three Antifungal Lipopeptides Isolated from Colispora cavincola. J. Nat. Prod. 2015, 78 (3): 468–475 – Abstract
Pascual J, García-López M, Bills GF, Genilloud O Pseudomonas granadensis sp. nov., a new bacterial species isolated from the Tejeda, Almijara and Alhama Natural Park, Granada, Spain. Int. J. Syst. Evol. Microbiol. 2015, 65: 625-632 – Asbtract
Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. ACS Infect. Dis. 2015, 1: 59-72 – Full Paper
Cautain B, De Pedro N, Reyes F, Link W Image-Based Identification of Nuclear Export Inhibitors from Natural Products. Methods Mol. Biol. 2015, 1270: 307-319 – Abstract
Lacret R, Oves-Costales D, Gómez C, Díaz C, de la Cruz M, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis. Mar. Drugs 2015, 13: 128-140 – Full Paper
Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo J R, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez L M, Navarro M, Gamarro F, González-Pacanowska D High throughput screening platform for Natural Product-based drug discovery against three Neglected Tropical Diseases: human African trypanosomiasis, leishmaniasis and Chagas disease. J. Biomol. Screen. 2015, 20: 82-91 – Abstract
Perez J, Díaz C, Asensio F, Palafox A, Genilloud O, Vicente F A Novel In Vitro Approach for Simultaneous Evaluation of CYP3A4 Inhibition and Kinetic Aqueous Solubility. J. Biomol. Screen. 2015, 20(2): 254-264 – Abstract
Cautain B, Hill R, de Pedro N, Link W Components and regulation of nuclear transport processes. FEBS J. 2015, 282(3): 445-462 – Full Paper
2014
Castillo Correa FJ, De Pedro N, Rodriguez Quesada L, Oves Costales D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014; 50 supplement: 6-24
Cantizani J, Ortiz J, Ravipati AS, Rodrigueza L, Cautain B, Zhang L, Reddy N, Nath CE, Vicente F, De Pedro N., and Koyyalamudi SR Screening for Natural Inhibitors in Chinese medicinal plants against Glycogen Synthase Kinase 3β (GSK-3β) Pharmacologia 2014, 5: 205-214
Ondeyka JG, Smith SK, Zink DL, Vicente F, Basilio A, Bills GF, Polishook JD, Garlisi C, Mcguinness D, Smith E, Qiu H, Gill CJ, Donald RGK, Phillips JW, Goetz MA, Singh SB Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin. J. Antibiot 2014, 67(7): 527-531
Genilloud O The re-emerging role of microbial natural products in antibiotic discovery. Antoine van Leeuwenhoek 2014, 106: 173-188
Martín-Rodríguez A J, Reyes F, Martín J, Pérez-Yépez J, León-Barrios M, Couttolenc A, Espinoza C, Trigos Á, Martín V, M. Norte, Fernández J J Inhibition of Bacterial Quorum Sensing by Extracts from Aquatic Fungi: First Report from Marine Endophytes. Mar. Drugs 2014, 12(11): 5503-5526 – Full Paper
Guimarães L A, Jimenez P C, Sousa T da S, Freitas H P S, Rocha D D, Wilke D V, Martín J, Reyes F, Pessoa O D L, Costa-Lotufo L V Chromomycin A2 induces autophagy in melanoma cells Mar. Drugs 2014, 12(12): 5839-55 – Full Paper
Martín J, Crespo G, González-Menéndez V, Pérez-Moreno G, Sánchez-Carrasco P, Pérez-Victoria I, Ruiz-Pérez L M, González-Packanowska D, Vicente F, Genilloud O, Bills G F, Reyes F MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii. J. Nat. Prod. 2014, 77(9):2118-23. – Abstract
Pascual J, García-López M, Carmona C, da S. Sousa T, de Pedro N, Cautain B, Martín J, Vicente F, Reyes F, F. Bills G, Genilloud O Pseudomonas soli sp. nov., a novel producer of xantholysin congeners. Syst. Appl. Microbiol 2014, 37(6): 412-6 – Abstract
González-Menéndez V, Asensio F, Moreno C, de Pedro N, Monteiro MC, de la Cruz M, Vicente F, Bills G, Reyes F, Genilloud O & Tormo JR Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity. Micology 2014, 5(3): 179-191 – Full Paper
Montiel R, Martín-Cabrejas I, Langa S, El Aouad N, Arqués J L, Reyes F, Medina M. Antimicrobial activity of reuterin produced by Lactobacillus reuteri on Listeria monocytogenes in cold-smoked salmon.Food Microbiol. 2014, 44: 1-5 – Abstract
Almeida C, El Aouad N, Martín J, Pérez-Victoria I, González-Menéndez V, Platas G, de la Cruz M, Monteiro MC, de Pedro N, Bills GF, Vicente F, Genilloud O, and Reyes F Graminin B, a furanone from the fungus Paraconiothyrium sp. J Antibiot 2014, 67: 421-423 – Abstract
Singh S, Ondeyka J, Buevich A, Williamson R, Zink D, Polishook J, Occi J, Vicente F, Basilio A, Bills G, Donald R, Phillips J, Goetz M Isolation, Structure Elucidation and Biological Activity of Altersolanol P using Staphylococcus aureus Fitness Test Based Genome-wide Screening. J. Nat. Prod. 2014, 77(3): 497-502
Siles JA, Pascual J, González-Menéndez V, Sampedro I, García-Romera I, Bills GF Short-term dynamics of culturable bacteria in a soil amended with biotransformed dry olive residue. Syst Appl Microbiol 2014, 37(2): 113-20
Siles JA, González-Menéndez V, Platas G, Sampedro I, García-Romera I, Bills GF Effects of Dry Olive Residue Transformed by Coriolopsis floccosa (Polyporaceae) on the Distribution and Dynamic of a Culturable Fungal Soil Community. Microb Ecol 2014, 67(3): 648-58
Hill R, Cautain B, de Pedro N & Link W Targeting Nucleocytoplasmic Transport in Cancer Therapy. Oncotarget 2014, 5(1): 11-28 – Abstract
Castelli MV, Butassi C, Monteiro MC, Svetaz LA, Vicente F, Zacchino SA Novel antifungal agents: a patent review (2011 – 2014), Exp Op Ther Pat: 24 (3): 1-16 – Abstract
Cautain B, de Pedro N, Murillo Garzón V, Muñoz de Escalona M, González Menéndez C, Tormo JR, Martin J, El Aouad N, Reyes F, Asensio F, Genilloud O, Vicente F and Link W A cell-based strategy using high-content imaging for the discovery of novel nuclear export inhibitors from natural products. J Biomol Screen 2014, 19: 57-65
2013
Chen L, Yue Q, Zhang X, Xiang M, Wang C, Li S, Che Y, Ortiz-López FJ, Bills GF, Liu X and An Z Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC Genomics 2013, 14: 339 – Abstract
Gracia AP, Bondoso J, Gaspar H, Xavier JR, Monteiro MC, de la Cruz M, Oves-Costales D, Vicente F, Lage OM Antimicrobial Activity of Heterotrophic Bacterial, Communities from the Marine Sponge Erylus discophorus (Astrophorida, Geodiidae). Plos One 2013, 8: 11, e78992 – Abstract
Cautain B, de Pedro N, Muñoz de Escalona M, Tormo JR, Genilloud O, Vicente F HCS Strategy Targeting Dysregulation Of The VHL/HIF Pathway For Drug Discovery. Adv Biosci and Biotechnol 2013, 4: 398-405 – Abstract
Singh SB, Zhang C, Zink DL, Herath K, Ondeyka J, Masurekar P, Jayasuriya H, Goetz MA, Tormo JR, Vicente F, Martín J, González I, Genilloud O Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening. J Antibiot 2013, 66: 599-607 – Abstract
Audoin C, Bonhomme D, Ivanisevic J, de la Cruz M, Cautain B, Monteiro MC, Reyes F, Rios L, Perez T and Thomas OP Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi. Mar Drugs 2013, 11: 1477-1489 – Abstract
Martín MJ, Coello L, Fernández R, Reyes F, Rodríguez A, Murcia C, Garranzo M, Mateo C, Sánchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, and Cuevas C Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds. J Am Chem Soc 2013, 135: 10164-10171 – Abstract
Palomo S, González I, Martín J, de la Cruz M, Vicente F, Reyes F, Tormo JR, Anderson M, Hill RT, Genilloud O Sponge-derived Kocuria and Micrococcus spp. as new sources of thiazolylpeptide antibiotics. Mar Drugs 2013, 11: 1071-1086 – Abstract
Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de la Cruz M, Monteiro MC, Melguizo A, Jiménez E, Vicente F Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pacific J Trop Med 2013, 6(9): 673-81 – Abstract
Sheo B. Singh John Ondeyka, Harris G, Herath K, Zink D, Vicente F, Bills G, Collado J, Platas G, González de Val A, Martin J, Reyes F, Wang H, Nielsen Kahn J, Galuska S, Giacobbe R, Abruzzo G, Roemer T, Xu D. Isolation, structure and biological activity of a cyclic lipodepsipeptide phaeofungin from a Phaeosphaeria sp. using the genome-wide Candida albicans Fitness Test. J Nat Prod 2013, 76: 334-345 – Abstract
García E, Alonso A, Platas G and Sacristán S. The endophytic mycobiota of Arabidopsis thaliana. Fungal divers 2013, 60: 71-89 – Abstract
de Pedro N, Cautain B, Melguizo A, Vicente F, Genilloud O, Peláez F, Tormo JR Mitochondrial complex I inhibitors, acetogenins, induce 5 HepG2 cell death through the induction of the complete 6 apoptotic mitochondrial pathway. J Bioenerg Biomembr 2013, 45: 153-164 – Abstract
De Pedro Montejo N, Cautain B, Melguizo A, Cortes D, Vicente F, Genilloud O, Tormo JR, Peláez F Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I. J Bioenerg Biomembr 20013, 45(1-2): 145-152 – Abstract
Martin J, da S Sousa T, Crespo G, Palomo S, Gonzalez I, Tormo JR, de la Cruz M, Anderson M, Hill RT, Vicente F, Genilloud O, Reyes F Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris. Mar Drugs 2013, 11: 387-98 – Abstract
Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de Pedro N, Melguizo A, Cantizani J, Asensio F, Vicente F Anti-proliferative activities of selected Chinese medicinal herbs against human cancer cell lines. Phytopharmacology 2013, 4(2): 206-219 – Abstract
Baral HO, Galán R, Platas G & Tena R Phaeohelotium undulatum comb. nov. and Phaeoh. succineoguttulatum sp. nov., two segregates of the Discinella terrestris aggregate found under Eucalyptus in Spain: taxonomy, molecular biology, ecology and distribution. Mycosystema 2013, 32(3): 386-428 – Abstract
Pérez J, Díaz C, Salado IG, Pérez DI, Peláez F, Genilloud O, Vicente F Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays. Adv Biosci Biotechnol 2013, 4: 628-639 – Abstract
2012
Singh SB, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, de la Cruz M, Martín J , Vicente F, Genilloud O, Donald RGK, Phillips JW Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities. Bioorg Med Chem letters 2012, 22: 7127-7130 – Abstract
Fernández-Acero T, Rodríguez-Escudero I, Vicente F, Monteiro MC, Tormo JR, Cantizani J, Molina M, Cid VJ A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors. J Biomol Screening 2012, 17(8): 1018-1029 – Abstract
Vicente MF, Bills G, Reyes F, Genilloud O Fundación MEDINA – Investigación en Terapias Innovadoras a partir de Productos Naturales aislados de Microorganismos. Especial Microbiología Industrial y Biotecnología Microbiana. Actualidad SEM 2012, 53: 32-35 – Article
Kai M, González I, Genilloud O, Singh SB, Svatoš A Direct mass spectrometric screening of antibiotics from bacterial surfaces using liquid extraction surface analysis. Rapid Commun. Mass Spectrom. 2012, 26(20): 2477-2482 – Abstract
Genilloud O Current Challenges in the Discovery of Novel Antibacterials from Microbial Natural Products. Recent Pat Antiinfect Drug Discov. 2012, 7(3): 189-204(16) – Abstract
Bills GF, Dombrowski AW and Goetz MA The “FERMEX” method for metabolite-enriched fungal extracts. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.). Meth Mol Biol 2012, 944(5): 79-96 – Abstract
Bills GF, González-Menéndez V, Martin J, Platas G, Fournier J, Peršoh D and Stadler M. Hypoxylon pulicicidumsp. nov. (Ascomycota, Xylariales), a Pantropical Insecticide-Producing Endophyte. PLOS One 2012, 7: e46687 – Abstract
Bills GF, González-Menéndez V and Platas G Kabatiella bupleuri sp. nov. (Dothideales), a pleomorphic epiphyte and endophyte of the Mediterranean plant, Bupleurum gibraltarium (Apiaceae). Mycologia 2012, 104: 962-973 – Abstract
Cueva C, Garcia Ruiz A, González-Rompinelli Bartolomé EB, Martín-Álvarez PJ, Salazar O, Vicente MF, Bills G and Moreno-Arribas V Degradation of biogenic amines by vineyard ecosystem fungi. Potential use in winemaking. J Appl Microbiol 2012, 112: 672-682 – Abstract
De la Cruz M, Martín J, González-Menéndez V, Pérez-Victoria I, Moreno C, Tormo JR, El Aouad N, Guarro J, Vicente F, Reyes F and Bills GF Chemical and physical modulation of antibiotic activity in Emericella species. Chem Biodiv 2012, 9: 1095-1113 – Abstract
El Aouad N, Pérez-Moreno G, Sánchez P, Cantizani J, Ortiz-López FJ, Martín J, González-Menéndez V, Ruiz-Pérez LM, González-Pacanowska D, Vicente F, Bills G and Reyes F Lasionectrin, a Naphthopyrone from a Lasionectria sp. J Nat Prod 2012, 75: 1228-1230 – Abstract
Genilloud O and Vicente F Novel approaches to exploit natural products from microbial resources. InDrug Discovery from Natural Products, Eds. O. Genilloud and F. Vicente, RSC series. 2012, Ch. 11: 221-248 – Book
Genilloud O Genus Micromonospora. In Bergey’s Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012 p. vol 5 B: 1039-1057 – Book
Genilloud O Suborder XI. Micromonosporineae and The family Micromonosporaceae. In Bergey’s Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012, vol 5 B: 1035-1038 – Book
Herath K, Jayasuriya H, Zink DL, Sigmund J, Vicente F, de la Cruz M, Basilio A, Bills GF, Polishook JD,DonaldR, Phillips J, Goetz M and Singh SB Isolation, structure elucidation and antibacterial activity of methiosetin, a new tetramic acid from a tropical sooty mold (Capnodium sp.). J Nat Prod 2012, 75: 420–424 – Abstract
Monteiro MC, de la Cruz M, Cantizani J, Moreno C, Tormo JR, Mellado E, de Lucas JR, Asensio F, Valiante V, Brakhage AA, Latgé J-P, Genilloud O and Vicente F A New Approach to Drug Discovery: High-Throughput Screening of Microbial Natural Extracts against Aspergillus fumigatus Using Resazurin. J Biomol Screen 2012, 17: 542-549 – Abstract
Pérez-Victoria I, Martín J, González-Menéndez V, de Pedro N, El Aouad N, Ortiz-López FJ, Tormo JR, Platas G, Vicente F, Bills GF, Genilloud O, Goetz MA and Reyes F Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica. J Nat Prod 2012, 75: 1210-1214 – Abstract
Sánchez-Hidalgo M, Pascual J, de la Cruz M, Martín J, Kath GS, Sigmund JM, Masurekar P, Vicente F, Genilloud O and Bills GF Prescreening bacteria colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system. Antonie van Leeuwenhoek 2012, 102: 361-374 – Abstract
Sánchez Márquez S, Bills GF , Herrero N and Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecol 2012, 5: 289–297 – Abstract
Tormo, JR, Asensio, FJ and Bills (GF) Manipulating filamentous fungus chemical phenotypes by growth in nutritional arrays. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.), Met Mol Biol 2012, vol. 944, 4: 59-78 – Abstract
Oves-Costales D and Challis GL Mining microbial genomes for metabolic products of cryptic pathways. InDrug Discovery from Natural Products, Eds. Genilloud O and Vicente F, RSC series 2012, 8: 140-158 – Abstract
2011
El Aouad N, Monteiro MC, Pérez-Moreno G, Cantizani J, Moreno C, Martín J, González I, Vicente F, Genilloud O, González-Packanowska D, Tormo JR, Reyes F. A new natural Pepstatin from Kitasatospora sp. (Actinomycetales) Planta Medica. 2011, 77: 1345. Abstract
Ferrer M, Guazzaroni ME, Richter M, García-Salamanca A, Yarza P, Suárez-Suárez A, Solano J, Alcaide M, van Dillewijn P, Molina-Henares MA, López-Cortés N, Al-Ramahi Y, Guerrero C, Acosta A, de Eugenio LI, Martínez V, Marques S, Rojo F, Santero E, Genilloud O, Pérez-Pérez J, Rosselló-Móra R, Ramos JL Taxonomic and Functional Metagenomic Profiling of the Microbial Community in the Anoxic Sediment of a Sub-saline Shallow Lake (Laguna de Carrizo, Central Spain). Microb Ecol 2011, 62: 824-37 – Abstract
Cueva C, Moreno-Arribas V, Bartolomé B, Salazar O, Vicente MF & Bills GF Antibiosis of vineyard ecosystem fungi against food-borne microorganisms. Res Microbiol 2011, 162: 1043–1051 – Abstract
Torres MS, Tadych M, White JF Jr. & Bills GF Dilution-to-extinction cultivation of endophytic fungi and isolation and detection of grass endophytic fungi in different plant parts, Isolation and identification of fungal endophytes. Pgs. 13-18, 153-164. In: Prospects and Applications for Plant-Associated Microbes. A Laboratory Manual, Part B: Fungi. Editors Pirttilä AM & Sorvari S. BioBien Innovations 2011, Paimio, Finland
Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho Santiago Castanys L, Gamarro F, Morales JC, Pérez-Victoria JM, Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry. Bioenergetics 2011, 1808: 717–726 – Abstract
Sánchez Márquez S, Bills GF & Zabalgogeazcoa I Fungal species diversity in juvenile and adult leaves of Eucalyptus globulus from plantations affected by Mycosphaerella leaf disease. Ann Appl Biol 2011, 158: 177-187 – Article
Campos-Salinas J, Cabello-Donayre M, García-Hernández R, Pérez-Victoria I, Castanys S, Gamarro F and Pérez-Victoria JM A new ATP binding cassette protein is involved in intracellular haem trafficking in Leishmania. Molecular Microbiology 2011, 79(6): 1430-44- Abstract
Genilloud O, González I, Salazar O, Martín J, Tormo JR, Vicente F Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol, 38: 375–389 – Abstract
Roemer T, Xu D, Singh SB, Parish CA, Harris G, Wang H, Davies JE and Bills GF Confronting the Challenges of Natural Product-Based Antifungal Discovery. Chem Biol 2011, 18: 148-164 – Abstract
Xu D, Ondeyka J, Harris GH, Zink D, Nielsen Kahn J, Wang H, Bills G, Platas G, Wang W, Szewczak AA, Liberator P, Roemer T, and Singh SB Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test. J Nat Prod 2011, 74 (8): 1721-1730 – Abstract
Gabriel Moreno, Maria-Natividad Blanco, Julia Checa, Gonzalo Platas, Fernando Peláez Taxonomic and phylogenetic revision of three rare irpicoid species within the Meruliaceae. Mycol Progress 2011, 10: 481-491 – Abstract
Peláez F, Collado J, Platas G, Overy DP, Martín J, Vicente F, González del Val A, Basilio A, de la Cruz M, Tormo JR, Fillola A, Arenal F, Villareal M, Rubio V, Baral HO, Galán R and Bills GF The phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensis. Mycology 2011, 2: 1–17 – Abstract
Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, Lee S, Skwish S, de la Cruz M, Martín J, Vicente F, Genilloud O, Lu J, Painter RE, Young K, Overbye K, Donald RGK, and Singh SB Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus. Chem Biol 2011, 18: 955–965 – Abstract
Sánchez Márquez S, Bills GF, Herrero N, Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecology 2011 , 5(3): 289–297 – Abstract
Tijerino A, Cardoza RE, Moraga J, Malmierca MG, Vicente F, Aleu J, Collado IG, Gutiérrez S, Monte E, Hermosa R Overexpression of the trichodiene synthase gene tri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. Fungal Genet Biol 2011, 48: 285–296 – Abstract
2010
El Aouad N, Ortiz-Lopez J, Martín J, Tormo JR, Goetz M and Genilloud O. New semi –automated method for the creation of a microbial fraction collection developed at Fundación MEDINA. Planta Medica 2010, 76: 1319 – Abstract
Ayers S, Zink DL, Mohn K, Powell JS, Brown CM, Bills G, Grund A, Thompson D and Singh SB Anthelmintic constituents of Clonostachys candelabrum. J Antibiot, 2010, 63: 119-122 – Abstract
Cueva C, Victoria Moreno-Arribas M, Martín-Alvarez PJ, Bills G, Vicente F, Basilio A, Lopez Rivas C, Requena T, Rodriguez JM and Bartolome B Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria. Res Microbiol 2010, 161: 372-382 – Abstract
Duetz W, Chase M and Bills G Miniaturization of fermentations. In Manual of Industrial Microbiology and Biotechnology, 3rd ed eds. Demain A, Davies J and Baltz R. pp.99-116. Washington, DC 2010: ASM Press – Book
Goetz MA, Zhang C, Zink DL, Arocho M, Vicente F, Bills GF, Polishook J, Dorso K, Onishi R, Gill C, Hickey E, Lee S, Ball R, Skwish S, Donald RGK, Phillips JW and Singh SB Coelomycin, a highly substituted 2,6-dioxo-pyrazine fungal metabolite antibacterial agent discovered by Staphylococcus aureus fitness test profiling. J Antibiot 2010, 63: 512-518 – Abstract
Márquez SS, Bills GF, Acuna LD and Zabalgogeazcoa I Endophytic mycobiota of leaves and roots of the grass Holcus lanatus. Fungal Diversity 2010, 41: 115-123 – Abstract
Peterson SW, Jurjevic Z, Bills GF, Stchigel AM, Guarro J and Vega FE Genus Hamigera, six new species and multilocus DNA sequence based phylogeny. Mycologia 2010, 102: 847-864 – Abstract
2009
Bills G, Overy DP, Genilloud O and Peláez F Contributions of pharmaceutical antibiotic and secondary metabolite discovery to the understanding of microbial defense and antagonism. In Defensive Mutualism in Microbial Symbiosis eds. White JF and Torres MS. pp.257-297 Boca Raton, USA 2010: CRC Press – Book
Bills GF, Martín J, Collado J, Platas G, Overy D, Tormo JR, Vicente F, Verkleij G and Crous P Measuring the distribution and diversity of antibiosis and secondary metabolites in the filamentous fungi. Society of Industrial Microbiology News 2009, 59: 133-147 – Abstract
Bills GF, Platas G, Overy D, Collado J, Fillola A, Jiménez MR, Martín J, Val AGd, Vicente F, Tormo JR, Peláez F, Calati K, Harris G, Parish C, Xu D and Roemer T Discovery of the parnafungins, antifungal metabolites that inhibit mRNA poly-adenylation, from the Fusarium larvarum complex and other hypocrealean fungi. Mycologia 2009, 101: 445-469 – Abstract
Blanco MN, Moreno G, Checa J, Platas G and Peláez F Taxonomic and phylogenetic revision of Coniophora arachnoidea, C. opuntiae, and C. prasinoides. Mycotaxon 2009, 108: 467-477 – Abstract
Donald RGK, Skwish S, Forsyth RA, Anderson JW, Zhong T, Burns C, Lee S, Meng X, LoCastro L, Jarantow LW, Martin J, Lee SH, Taylor I, Robbins D, Malone C, Wang LS, Zamudio CS, Youngman PJ and Phillips JW AStaphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds. Chem Biol 2009, 16: 826-836 – Abstract
Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu DM, Roemer T and Singh SB (2009) Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp. Bioorg Med Chem 2009, 17: 1361-1369 – Abstract
Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, Platas G, Collado J, González A, de la Cruz M, Martin J, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Jiang B, Xu DM, Roemer T and Singh SB Isolation, structure elucidation, and biological activity of virgineone from Lachnum virgineum using the genome-wide Candida albicans fitness fest. J Nat Prod 2009, 72: 136-141
Overy D, Calati K, Kahn JN, Hsu M-J, Martin J, Collado J, Roemer T, Harris G and Parish CA Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products. Bioorg Med Chem Lett 2009, 19: 1224-1227 – Abstract
Parish CA, de la Cruz M, Smith SK, Zink D, Baxter J, Tucker-Samaras S, Collado J, Platas G, Bills G, Díez MT, Vicente F, Peláez F and Wilson K Antisense-guided isolation and structure elucidation of pannomycin, a substituted cis-decalin from Geomyces pannorum. J Nat Prod 2009, 72: 59-62 – Abstract
Platas G, González V, Collado J, Martín J, Montes C and Peláez F Ascription of poorly defined taxa to taxonomic entities using molecular phylogenies: a case study on Nodulisporium sp producers of nodulisporic acid. Mycotaxon 2009, 109: 443-460 – Abstract
Rojas JL, Martín J, Tormo JR, Vicente F, Brunati M, Ciciliato I, Losi D, Trappen SV, Mergaert J, Swings J, Marinelli F and Genilloud O Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites. Marine Genomics 2009, 2: 33-41 – Abstract
Singh SB, Jayasuriya H, Zink D, Basilio A, Vicente F, Collado J, Bills G, Lee Goldman M, Motyl M, Huber J, Dezeny G & Byrne K Discovery and antibacterial activity of glabramycin A-C from Neosartorya glabra by an antisense strategy. J Antibiot, 2009, 62: 265-269 – Abstract
Singh SB, Genilloud O and Peláez F NP structural diversity II – Secondary metabolite sources, evolution and selected molecular structures: Terrestrial micro-organisms – bacteria. In Comprehensive Natural Products Chemistry II eds. Moore, B and CrewsP., 2009, 109-140. UK: Elsevier – Book
Singh SB, Zink DL, Dorso K, Motyl M, Salazar O, Basilio A, Vicente F, Byrne KM, Ha S and Genilloud O Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered fromStreptomyces lucensis MA7349 using an antisense strategy. J Nat Prod 2009, 72: 345-352 – Abstract
Vicente F, Basilio A, Platas G, Collado J, Bills GF, González del Val A, Martín J, Tormo JR, Harris GH, Zink DL, Justice M, Kahn JN and Peláez F Distribution of the antifungal agents sordarins across filamentous fungi. Mycol Res 2009, 113: 754-770 – Abstract
Zhang C, Ondeyka JG, Zink DL, Basilio A, Vicente F, Salazar O, Genilloud O, Dorso K, Motyl M, Byrne K and Singh SB Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4. J Antibiot 2009, 62: 55-61 – Abstract
Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy. Bioorg Med Chem 2009, 17: 2162-2166 – Abstrac
2008
Ayers S, Zink DL, Powell JS, Brown CM, Grund A, Bills GF, Platas G, Thompson D and Singh SB Noreupenifeldin, a tropolone from an unidentified ascomycete. J Nat Prod 2008, 71: 457-459 – Abstract
Bills GF, Platas G, Fillola A, Jiménez MR, Collado J, Vicente F, Martín J, González A, Bur-Zimmermann J, Tormo JR and Peláez F Enhancement of antibiotic and secondary metabolite detection from filamentous fungi by growth on nutritional arrays. J Appl Microbiol 2008, 104: 1644-1658 – Abstract
Jiang B, Xu DM, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu WQ, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Peláez F, Díez MT, Kauffman S, Becker J, Harris G, Liberator P and Roemer T PAP inhibitor with in vivo efficacy identified byCandida albicans genetic profiling of natural products. Chem Biol 2008, 15: 363-374 – Abstract
Moreno G, Platas G, Peláez F, Bernedo M, Vargas A, Daza A, Santamaria C, Camacho M, de la Osa LR and Manjon JL Molecular phylogenetic analysis shows that Amanita ponderosa and A. curtipes are distinct species. Mycol Prog 2008, 7: 41-47 – Abstract
Ortega A, Moreno G, Platas G and Peláez F A new Armillaria mellea variant from tops of coastal sand dunes in southern Spain. Mycotaxon2008, 104: 349–364 – Abstract
Parish CA, Smith SK, Calati K, Zink D, Wilson K, Roemer T, Jiang B, Xu DM, Bills G, Platas G, Peláez F, Díez MT, Tsou N, McKeown AE, Ball RG, Powles MA, Yeung L, Liberator P and Harris G Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation. J Am Chem Soc 2008, 130: 7060-7066 – Abstract
Peláez F, González V, Platas G, Sánchez-Ballesteros J and Rubio V Molecular phylogenetic studies within the Xylariaceae based on ribosomal DNA sequences. Fungal Divers 2008, 31: 111-134 – Abstract
Rincón A, Arenal F, González I, Manrique E, Lucas MM Pueyo JJ Diversity of rhizobial bacteria isolated from nodules of the gypsophyte Ononis tridentata L. growing in Spanish soils. Microb Ecol 2008, 56: 223-233 Abstract
Rossman AY, Farr DF, Platas G and Newcombe G Hydropisphaera fungicola Rossman, Farr & Newcombe sp. nov. Fungal Planet 2008, 24 – Article
Ruibal C, Platas G and Bills GF High diversity and morphological convergence among melanised fungi from rock formations in the Central Mountain System of Spain. Persoonia 2008, 21: 93-110 – Article
Sánchez S, Bills GF and Zabalgogeazcoa I Fungal endophytes from two sympatric coastal grasses. Fungal Divers 2008, 33: 87-100 – Article
Singh SB, Zink DL, Herath KB, Salazar O and Genilloud O Discovery and antibacterial activity of lucensimycin C from Streptomyces lucensis. Tetrahedron Lett 2008, 49: 2616-2619 – Abstract
Zhang CW, Occi J, Masurekar P, Barrett JF, Zink DL, Smith S, Onishi R, Ha SH, Salazar O, Genilloud O, Basilio A, Vicente F, Gill C, Hickey EJ, Dorso K, Motyl M and Singh SB Isolation, structure, and antibacterial activity of philipimycin, a thiazolyl peptide discovered from Actinoplanes philippinensis MA7347. J Am Chem Soc 2008, 130: 12102-12110 – Abstract
Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Bills G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure, and antibacterial activity of phaeosphenone from a Phaeosphaeria sp discovered by antisense strategy. J Nat Prod 2008, 71: 1304-1307 – Abstract