Publicaciones Científicas

Rotter A, Bacu A, Barbier M, Bertoni F, Bones A M, Cancela M L, Carlsson J, Carvalho M F, Cegłowska M, Dalay M C, Dailianis T, Deniz I, Drakulovic D, Dubnika A, Einarsson H, Erdoğan A, Eroldoğan O T, Ezra D, Fazi S,FitzGerald R J, Gargan L M, Gaudêncio S P, DeNardis N I, Joksimovic D, Kataržytė M, Kotta J, Mandalakis M, Matijošytė I, Mazur-Marzec H, Massa-Gallucci A, Mehiri M, Nielsen S L, Novoveská L, Overlingė D, Portman M E, Pyrc K, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Rudovica V, Sabotič J, Safarik I, Talve S, Tasdemir D, Schneider X T, Thomas OP, Toruńska-Sitarz A, Varese G C, Vasquez . A new network for the advancement of marine biotechnology in Europe and beyond. Front. Mar. Sci., 2020; 7:278. Abstract

Martín-Blázquez A, Jiménez-Luna C,Díaz C, Martínez-Galán J, Prados J, Vicente F, Melguizo C, Genilloud O, Pérez del Palacio J, Caba O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers, 2020, 12(4), 1002. Abstract

Berenguel Hernández A M., De la Cruz M, Alcázar-Fabra M, Prieto-Rodríguez A, Sánchez-Cuesta A, Martin J, Tormo J R, Rodríguez-Aguilera J C, Cortés-Rodríguez A B, Navas P, Reyes F, Vicente F, Genilloud O, Santos-Ocaña C. Design of high-throughput screening of natural extracts to identify molecules bypassing primary coenzyme Q deficiency in Saccharomyces cerevisiae. SLAS Discov., 2020, 25, 299-309. Abstract

Salamanca-Fernández E,Rodríguez-Barranco M, Arrebola JP, Vela F, Díaz C, Chirlaque M D, Colorado-Yohar S, Jiménez-Zabala A, Irizar A, Guevara M, Ardanaz E, Iribarne-Durán LM, Pérez del Palacio J, Olea N, Agudo A, Sánchez MJ. Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors. Environmental Research,2020, 182, 109012. Abstract

Lauritano C, Martínez K A, Battaglia P, Granata A, De la Cruz M, Cautain B, Martín J, Reyes F, Ianora A, Guglielmo L. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Sci Rep., 10, 4929 (2020).  Abstract

Diogo Santos J, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez I, Tormo J R, Martin J, Vicente MF, Lage OM. Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges. Antonie van Leeuwenhoek, (2020). doi: 10.1007/s10482-020-01398-2.   Abstract

Sánchez-Hidalgo M, Martín J, Genilloud O. Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator. Antibiotics, 2020, 9(2), 67.  Abstract

Georgousaki K, Tsafantakis N, Gumeni S, Lambrinidis G, González-Menéndez V, Tormo JR, Genilloud O, Trougakos IP, Fokialakis N. Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules. Molecules, 2020, 25(3), 666. Abstract

Fang Q , Maglangit F , Wu L, Ebel R, Kyeremeh K, Andersen JH, Annang F, Pérez-Moreno G,Reyes F, Deng H. Signalling and Bioactive Metabolites from Streptomyces sp. RK44, Molecules, 2020, 25(3), 460. Abstract

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Generation of new sipanmycin analogues by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway. Appl. Environ. Microbiol., 2020, 86, e02453-19.  Abstract

Georgousaki, K., Tsafantakis, N., Gumeni, S., Gonzalez, I., Andrew Mackenzie, T., Reyes F., Lambert, C., Trougakos, I.P., Genilloud, O., Fokialakis, N., Screening for tyrosinase inhibitors from actinomycetes; Identification of trichostatin derivatives from Streptomyces sp. CA-129531 and scale up production in bioreactor. Bioorg Med Chem Lett., 2020, 15;30(6):126952.  Abstract

Romain Koagne R, Annang F, Cautain B, Martín J, Pérez-Moreno G, Thierry M. Bitchagno G, González-Pacanowska D, Vicente F, Konga Simo I, Reyes F & Tane P. Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae). BMC Complementary Medicine and Therapies, 2020,15;20(1):8.  Abstract

Carretero-Molina D, Ortiz-López F J, Martín J, Oves-Costales D, Díaz C, De la Cruz M, Cautain B, Vicente F, Genilloud O, Reyes F. New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078. Mar. Drugs, 2020, 18(1), 22.  Abstract

Mazzotta S, Marrugal-Lorenzo J A, Vega-Holm M, Serna-Gallego A, Álvarez-Vidal J, Berastegui-Cabrera J, Pérez del Palacio J, Díaz C, Aiello F, Pachón J,Iglesias-Guerra F,Vega-Pérez J M, Sánchez-Céspedes J. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents. Eur J Med Chem., 2020, 1;185. Abstract

 

Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer. Sci Rep., 9, 20198 (2019). Abstract

Almeida C, Mackenzie TA, González-Menendez V, De Pedro N, Pérez-Victoria I, Crespo G, Martín J, Genilloud O, Vicente F, Cautain B, Reyes F. Laccaridione C, a Bioactive Polyketide from the Fungus Montagnula sp. PMIO, 2019; 6(02): e57-e62. Abstract

Barúa JE, De la Cruz M, De Pedro N, Cautain B, Hermosa R, Cardoza RE, Gutiérrez S, Monte E, Vicente F, Collado IG. Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities. Molecules, 2019, 24, 3811 Abstract

Cabello-Donayre M, Orrego LM, Herráez E, Vargas P, Martínez-García M, Campos-Salinas J, Pérez-Victoria I, Vicente B, Marín JJG, Pérez-Victoria JM. Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite. Cell. Mol. Life Sci., 2019. doi: 10.1007/s00018-019-03258-3.  Abstract

Tejman-Yarden N, Robinson A, Davidov Y, Shulman A, Varvak A, Reyes F, Rahav G, Nissan I. Delftibactin-A, a Non Ribosomal Peptide with Broad Antimicrobial Activity. Front. Microbiol., 10:2377  doi: 10.3389/fmicb.2019.02377.  Abstract

Reina JC, Pérez-Victoria I, Martín J, Llamas I. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar. Drugs, 2019, 17: 494. Abstract

González-Menéndez V, Crespo G, Toro C, Martín J, de Pedro N, Tormo JR, Genilloud O. Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani. Metabolites, 2019, 9: 197. Abstract

Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, González I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J. Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. Molecules, 2019, 24: 2239. Abstract

Peyrat L-A, Tsafantakis N, Georgousaki K, Ouazzani J, Genilloud O, Trougakos IP, Fokialakis N. Terrestrial Microorganisms: Cell Factories of  Bioactive Molecules with Skin Protecting  Applications. Molecules, 2019, 24: 1836. Abstract

Georgousaki K, Tsafantakis N, Gumeni S, González-Menéndez V, de Pedro N, Tormo JR, Almeida C, Lambert C, Genilloud O, Trougakos IP, Fokialakis N. Cercospora sp. as a source of anti-aging polyketides targeting 26S proteasome and scale-up production in submerged bioreactor. J Biotechnol., 2019, 301: 88-96. Abstract

Martínez KA, Lauritano C, Druka D, Romano G, Grohmann T, Jaspars M, Martín J, Díaz C, Cautain B, de la Cruz M, Ianora A, Reyes F. Amphidinol 22, a new cytotoxic and antifungal amphidinol from the dinoflagellate Amphidinium carterae. Mar. Drugs, 2019, 17: 385. Abstract

Díaz C, Pérez del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J. Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate. ACS Infectious Diseases., 2019, 5: 1317-1326. Abstract

Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez Martinez I, Tormo JR, Martín JM, Urbatzka R, Vicente FM, Lage OM. Bioactivities and Extract Dereplication of Actinomycetales isolated from Marine Sponges. Front Microbiol., 2019, 10: 727. Abstract

Pérez del Palacio J, Díaz-Navarro C, Martín-Blázquez A, González-Olmedo C, Vergara-Segura N, Algieri F, Rodriguez-Nogales A, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, Rodríguez-Cabez MA. Metabolomic analysis of Lavandula dentata L. and Lavandula stoechas L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool. Plant. Biosyst., 2019, 154:231-240.  Abstract

Butassi E, Svetaz LA, Zhou S, Wolfender JL, G. Cortés JC, Ribas JC, Díaz-Navarro C, Pérez del Palacio J, Vicente F, Zacchino SA. The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera.  Phytomedicine, 2019, 60: 152884.  Abstract

Martín J, Reyes F, Vicente F, Gamboa-Angulo M, Escalante-Réndiz D, De la Rosa García S, Tapia-Tussell R. Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity. Int J. Environ. Res. Public Health, 2019, 16: 1913. Abstract

Khentoul H, Bensouici C, Reyes F, Albanese D, Sarri D, Mekkiou R, Benayache F, Seghiri R, Boumaza O. Chemical constituents and HRESI-MS analysis of an Algerian endemic plant-Verbascum atlanticum Batt.- extracts and their antioxidant activity. Nat. Prod. Res., 2019, 22: 1-5.  Abstract

Guillen PO, Jaramillo KB, Jennings L, de la Cruz M, Cautain B, Reye Fs, Rodríguez J, Thomas OP. Halogenated tyrosine derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini. J. Nat. Prod., 2019, 82: 1354-1360. Abstract

Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P. Activation of secondary metabolite gene clusters in Streptomyces clavuligerus by the PimM regulator of Streptomyces natalensis. Front. Microbiol., 2019, 10: 580. Abstract

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Caniferolide A, a macrolide from Streptomyces caniferus, attenuates neuroinflammation, oxidative stress, amyloid-beta and tau pathology in vitro. Mol. Pharm., 2019, 16: 1456-1466.   Abstract

Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Diaz C, Cautain B,   Vicente F, Genilloud O, Reyes F. Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive glycosylated 36-membered polyol macrolides from the marine-derived Streptomyces caniferus CA-271066. Org. Biomol. Chem., 2019, 17:2954-2971.  Abstract

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Gloria Blanco. Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva spMar. Drugs, 2019, 17 (2) : 114. Abstract

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J,  Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M,  Specker E, Bartunek P, Simova S, Les´nikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, and Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discover., 2019, 24: 398-413.  Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2019, 33: 66-73 Abstract

Castillo F., Mackenzie T.A., Cautain B. Immunofluorescence Analysis by Confocal Microscopy for Detecting Endogenous FOXO. Link W. (eds) FOXO Transcription Factors. Methods in Molecular Biology, 2019, 1890: 143-149. Abstract

Koagne RR, Annang F, de la Cruz M, Bitchagno GTM, Perez-Victoria I, Konga IS, Vicente F, Reyes F, Tane P. Antibacterial Activity of Flavans from Crinum distichum. Natural Product Communications 2018, 13 : 637-1638. Abstract

Genilloud O. Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm? Antibiotics, 2018, 7: 85. Abstract

Calabro K, Chalén BE, Genta-Jouve G, Jaramillo KB, Domínguez C, de la Cruz M, Cautain B, Reyes F, Thomas OP, Rodríguez J. Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californicaJ. Nat. Prod., 2018, 81, 2301-2305. Abstract

Rodríguez V, J. Martín, A. Sarmiento-Vizcaíno, M. de la Cruz, L. A. García, G. Blanco, Reyes F. Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169.Mar. Drugs2018, 16: 406. Full text

Ortiz-López FJ, Alcalde E, Sarmiento-Vizcaíno A, Díaz C, Cautain B, García, Blanco G, Reyes F. New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157Mar. Drugs, 2018, 16: 371. Abstract

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitroNeuropharmacology, 2018, 141: 283-295. Abstract

Solanki H, Angulo-Preckler C, Calabro K, Kaur N, Lasserre P, Cautain B, de la Cruz M, Reyes F, Avila C, Thomas OP. Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905).Tetrahedron Lett., 2018, 59: 3353-3356. Abstract

Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353. J. Nat. Prod., 2018, 81: 1687-1691. Abstract

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Olano C, Salas JA, Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149. Appl Environ Microbiol 84:e01462-18. Abstract

Li F, Janussen D, Peifer C, Pérez-Victoria I, Tasdemir D, Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity. Mar. Drugs 2018, 16, 268. Abstract

Lage OM, Ramos MC, Calisto R, Almeida E, Vasconcelos V, Vicente F. Current Screening Methodologies in Drug Discovery for Selected Human Diseases.Marine Drugs. 2018; 16(8):279. Full article

Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo-Contreras E, Martín J, Machenzie T, Ruiz-Pérez L, González-Packanowska D, Genilloud O, Vicente F, Agyare C, Reyes F. Bioassay-guided isolation of four new antiprotozoal compounds from two Ghanaian mushrooms. Fitoterapia 2018 Jun, 127:341-348. Abstract

González-Menéndez V, Crespo G, De Pedro N, Diaz C, Martín J, Serrano R, Mackenzie TA, Justicia C, González-Tejero MR, Casares M, Vicente F, Reyes F, Tormo JR, Genilloud O. Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents. Nature.com, Scientific Reports, 2018, 8: 9729. Abstract

Almeida C, Silva Pereira C, González-Menéndez V, Bills G, Pascual J, Sánchez-Hidalgo M, Kehraus S, Genilloud O. Unveiling concealed functions of endosymbiotic bacteria harboured in the Ascomycota Stachylidium bicolor.Appl. Environ. Microbiol., 2018, DOI: 10.1128/AEM.00660-18. Abstract

Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O. Unprecedented non-geminal aliphatic dihalogenation pattern in dichlorinated diaporthins from Hamigera fusca NRRL 35721J. Nat. Prod., 2018, DOI:10.1021/acs.jnatprod.8b00041. Abstract

Sarmiento-Vizcaíno A, Espadas J, Martín J, Braña AF, Reyes F, García LA, Blanco G. Atmospheric precipitations, hailstone and rainwater, as a novel source of Streptomyces producing bioactive natural productsFront. Microbiol., 2018, 9:773. Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Natural product Research, 2018, https://doi.org/10.1080/14786419.2018.1434636. Abstract

Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, Díaz-Navarro C, Pérez-Del Palacio J, García-Fernández M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla-Ortega E. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018 May 1;133:189-201. Abstract

Pachón-Ibáñez ME, Labrador-Herrera G, Cebrero-Cangueiro T, Díaz C, Smani Y, del Palacio JP, Rodríguez-Baño J, Pascual A, Pachón J and Conejo MC. Efficacy of Colistin and Its Combination with Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae.Front. Microbiol 2018. 9:912. Abstract

Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N,  Vallorani R, Diaz C, Pérez del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM. Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A, ACS Chem. Neurosci. 2018 DOI10.1021/acschemneuro.8b00060. Abstract

Ramos MC, Genilloud O, Reyes F, Vicente F. Drug Discovery from Natural Products for Pancreatic Cancer. Pancreatic Cancer Book. Intech, 2018. DOI: 10.5772/intechopen.76399 Abstract

Sánchez M, González I, Díaz C, Martínez G and Genilloud O. Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains.Front. Microbiol. 2018, 9:369. doi: 10.3389/fmicb.2018.00369. Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2018, DOI:10.1080/14786419.2018.1434636. Abstract

Lauritano C, Martín J, de la Cruz M, Reyes F, Romano G, Ianora A. First identification of marine diatoms with anti-tuberculosis activity. Sci. Rep., 2018, 8:2284. Abstract

Sánchez L, Ladrón de Guevara D, Mañas MC, Alén F, Moreno RD, Díaz C, Perez del Palacio J, García M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla E, Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects ofethanol on the brain and behavior. Neuropharmacology (2018), doi: 10.1016/j.neuropharm.2018.01.033. Abstract

Pérez-Bonilla M, Oves-Costales D, de la Cruz M, Kokkini M, Martín J, Vicente F, Genilloud O and Reyes F. Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp. Mar. Drugs 2018, 16(3), 95; doi:10.3390/md16030095. Abstract

Castillo F, Mackenzie TA, Cautain B. Immunofluorescence analysis by confocal microscopy for detecting endogenous FOXO. Methods in Molecular Biology, DOI 10.1007/978-1.

Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA. Searching for glycosylated natural products in actinomycetes and identification of novel macrolactams and angucyclines. Front. Microbiol., 2018, 9:39. Abstract

Firsova D, Calabro K, Lasserre P, Reyes F, Thomas OP. Isoguanosine Derivatives from the Northeastern Atlantic Sponge Clathria (Microcionastrepsitoxa. Tetrahedron Lett., 2017, 58:4652-4654. Abstract

Genilloud O. Actinomycetes: still a source of novel antibiotics. Nat. Prod. Rep., 2017,34, 1203-1232, 10.1039/C7NP00026J. Abstract

Genilloud O, Industrial Culture Collections: Gateways from Microbial Diversity to Applications  in Microbial Resources: From Functional Existence in Nature to Applications, Ed J. Wink, 2017, Academic Press 237-256.

Ilic J, Cosic J, Vrandecic K, Dugalic K, Pranjic A, Martin J. Influence of endophytic fungi isolated from symptomless weeds on cherry plants. Mycosphere 2017: 8, 18-30. Full article

Peláez F, de Pedro N, Tormo JR. Chapter 9 of the book: Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Toxicological Implications, in Natural Products Targeting Clinically Relevant Enzymes (eds P. B. Andrade, P. Valentão and D. M. Pereira), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2017, Germany. doi: 10.1002/9783527805921

Braña AF, Sarmiento-Vizcaíno A, Osset M, Pérez-Victoria I, Martín J, de Pedro N, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G.  Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa. Mar. Drugs, 2017, 15:144. Abstract

Calabro K, Kalahroodi EL, Rodrigues D, Díaz C, Cruz M, Cautain B, Laville R, Reyes F, Pérez T, Soussi B, Thomas OP. Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866). Mar Drugs, Jun 15:199, doi: 10.3390/md15070199. Abstract

Pascual J, García-López M, González I, Genilloud O. Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers. International Journal of Systematic and Evolutionary Microbiology, Sept. 67(10), DOI:10.1099/ijsem.0.002227. Abstract

Martínez G, González-Menéndez V, Martín J, Reyes F, Genilloud O, Tormo JR. MASS Studio: A Novel Software Utility to Simplify LC-MS Analyses of Large Sets of Samples for Metabolomics. In: Rojas I., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science, vol 10208. Springer, Cham. Abstract

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Correction for Bertoni-Mann et al., “Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum CF-295141, Isolated from Pinus sylvestris ”. Genome Announcements 2017, 5(43):e01116-17., DOI:10.1128/genomeA.01116-17. Abstract

Almeida C, Bills G, González-Menéndez V, Martin J, Tormo JR, Genilloud O. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04. Fermentation 2017, 3(3):45., DOI:10.3390/fermentation3030045. Full paper

Boulaiz H, Ramos MC, Griñán-Lisón C, García-Rubiño ME, Vicente F, Marchal JA, What’s new in the diagnosis of pancreatic cancer: a patent review (2011-present), Expert Opinion. Expert Opin Ther Pat. 2017, Sept 10: 1-16. Full paper

Gonzalez-Menendez V, Martin J, Siles JA, Gonzalez-Tejero MR, Reyes F, Platas G, Tormo JR, Genilloud O. Biodiversity and chemotaxonomy of Preussia isolates from the Iberian PeninsulaMycol Progress 2017, Vol.16, 7:713 – 728. Full paper

Ramos MC, Boulaiz H, Griñan-Lison C, Marchal JA, Vicente F. What's new in treatment of pancreatic cancer: a patent review (2010-2017). Expert Opin Ther Pat. 2017, Jul 12:1-16, Full paper

Serrano R, González V, Rodríguez L, Martín J, Tormo JR, Genilloud O. Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents. Front. Microbiol., 2017, 649, Full paper

Pérez-del Palacio J, Díaz  C, Vergara N, Algieri F, Rodríguez-Nogales A, de Pedro N, Rodríguez-Cabezas ME, Genilloud O, Gálvez J, Vicente F. Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. Front. Pharmacol, 2017, Full paper

Sonnenschein EC, Stierhof M, Goralczyk S, Vabre FM, Pellissier L, Hanssen KE, de la Cruz M, Díaz C, de Witte P, Copmans D, Andersen JH, Hansen E, Kristoffersen V, Tormo JR, Ebel R, Milne BF, Deng H, Gram L, Jaspars M, Tabudravu JN. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040.Tetrahedron, 2017, Chemical Engineering Journal, 2017, 320: 151-159. Abstract

Vela-Soria F, Gallardo Torres ME, Ballesteros O, Diaz C, Perez J, Navalón A, Fernandez MF, Olea N. Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Cromatography A, 2017, 1487: 153-161. Abstract

Borges-Argáez R, Cáceres-Farfán M, De Pedro N, Cautain B, Pérez del Palacio P, Vicente F, Genilloud O, Melguizo A, Díaz C, Reyes F, El Aouad N, Sansores-Peraza P. Cytotoxic studies and in vitro effects oftrans -3,4,4’,5-Tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth. Polibotanica, 2017, 43: 165-175. Full paper

Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, De Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MJ, Vicente F, Genilloud O, Tormo JR, Reyes F. Hormonemate Derivatives from the Endophytic Fungus Dothiora sp.J. Nat. Prod., 2017, DOI: 10.1021/acs.jnatprod.6b00680. Full paper

Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina spPlanta Med., 2017, 05: 366-491. Abstract

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, De la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Branimycins B and C, Antibiotics Produced by the abyssal Actinobacterium Pseudonocardia carboxydivorans M-227J. Nat. Prod., 2017, 80: 569-573. Abstract

De la Cruz M, González I, Parish C, Onishi R, Tormo JR, Martín J, Peláez F, Zink D, El Aouad N, Reyes F, Genilloud O, Vicente F. Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes.Front. Microbiol., 2017, 8:343. Fullpaper

Paytubi S, De la Cruz M, Tormo JR, Martín J, González I, González-Menéndez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C. Microbial Natural Products High-Throughput Screening Platform for the Discovery of Molecules with Antibiofilm Properties Against Salmonella.Front. Microbiol., 2017, 8: 326. Fullpaper

González A, Gálvez N, Martín J, Reyes F, Pérez-Victoria I, Dominguez-Vera JM. Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption.Food Chem., 2017, 228: 374-380. Abstract

Trabelsi I, Oves D, Manteca A, Genilloud O, Altalhi A, Nour M. Antimicrobial Activities of Some Actinomycetes Isolated from Different Rhizospheric Soils in Tunisia. Current Microbiology 2016, 73:220-227. Abstract

Cautain B, Castillo F, Musso L, Ferreira BI, de Pedro N, Rodríguez Quesada L, Machado L, Vicente F, Dallavalle S, Link W. Discovery of a Novel Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS ONE 2016, 11: e0167491. Abstract

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Draft Genome Sequence of Phytopathogenic Fungus Fusarium fujikuroi CF-295141, Isolated from Pinus sylvestris.Genome Annoucements 2016, 4: e01163-16. Abstract

Lacret R, Pérez-Victoria I, Oves-Costales D, de la Cruz M, Domingo E, Martín J, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0170, a new napyradiomycin from Streptomyces sp. strain CA-271078.Mar. Drugs 2016, 14: 188. Abstract

Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina spPlanta Med. 2016, 81(S01): S1-S381. Abstract

Stierhof M, Hansen KO, Sharma M, Feussner K, Subko K, Fernandez Díaz-Rullo F, Isaksson J, Pérez-Victoria I, Clarke D, Hansen E, Jaspars M, Tabudravu JN. New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.Tetrahedron 2016, 72: 6929-6934. Abstract

Angulo-Preckler C, Genta-Jouve G, Mahajan N, de la Cruz M, de Pedro N, Reyes F, Iken K, Avila C, Thomas OP. Gersemiols A-C and Eunicellol A, Diterpenoids from the Arctic Soft coral Gersemia fruticosa.J. Nat. Prod. 2016, 79: 1132-1136. Abstract

Pascual J, González I, Estévez M, Benito P, Trujillo ME, Genilloud O. Description of Kibdelosporangium banguiense sp. nov., a novel actinomycete isolated from soil of the forest of Pama, on the plateau of Bangui, Central African Republic.Antoine van Leeuwenhoek 2016, 109: 685-695. Abstract

Pascual J, García-López M, Bills GF, Genilloud O. Longimicrobium terrae gen. nov., sp. nov., a novel oligotrophic bacterium of the underrepresented phylum Gemmatimonadetes isolated through a system of miniaturized diffusion chambers.Int. J. Syst. Evol. Microbiol. 2016, 66: 1976-85. Abstract

García-Fontana B, Morale-Santana S, Díaz Navarro C, Rozas-Moreno P, Genilloud O, Vicente Pérez F, Pérez del Palacio J, Muñoz-Torres M. Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study.Talanta 2016, 148: 135-143. Abstract

Sekurova ON, Pérez-Victoria I, Martin J, Degnes KF, Sletta H, Reyes F, Zotchev SB, New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07, Molecules 2016, 21(9): 1131. Abstract

De Pedro N, Cautain B, Cantizani J, Rodriguez L, Vicente F, Tualsi R and Rao Koyyalamudi S. In vitro Neuroprotective Effects of Seven Natural products Against Rotenone-Induced Toxicity in a SH-SY5Y Neuroblastoma Cells Model for Parkinson’s Disease. Pharmacologia 2016, 7: 361-370. Full paper

Vela-Soria I, Jiménez-DíazC, Díaz J, Pérez LM, Iribarne-Durán L, Serrano-López JP, Arrebola1 MF, Fernández N, Olea. Determination of endocrine disrupting chemicals in human milk by dispersive liquid-liquid microextraction. Bioanalysis 2016, 17: 1777-91. Abstract

Algieri F, Rodriguez-Nogales A, Vezza T, Garrido-Mesa J, Garrido-Mesa N, Utrilla MP, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, del Mar Contreras M, Segura-Carretero A, Pérez-Palacio J, Diaz C, Vergara N, Vicente F, Rodriguez-Cabezas ME, Galvez J: Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.J Ethnopharmacol 2016, 190: 142–158. Abstract

Annang F, Genilloud O, Vicente F. Contribution of Natural Products to Drug Discovery in Tropical Diseases. Chapter · July 2016, In book: Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery, pp.75-104

Vicente F, Reyes F, Genilloud O. Fungal secondary metabolites as source of antifungal compounds. In Fungi: Applications and their Management Strategies. Sunil K. Deshmukh, J. K. Misra, Jalpa P. Tewari, Tamas Papp Eds., CRC Press, 2016. ISBN: 9781498724913, pp. 80-116. Summary

Gonzalez-Menéndez V, Pérez-Bonilla M, Pérez-Victoria I, Martín J, Muñoz F, Reyes F, Tormo JR, Genilloud O. Multicomponent analysis of the differential induction of secondary metabolite profiles in fungal endophytes. Molecules 2016, 21(2): 234 Full paper

Pérez del Palacio I, Díaz C, De la Cruz M, Annang F, Martín J, Pérez-Victoria I, González-Menéndez V, De Pedro N, Tormo JR, Algieri F, Rodriguez-Nogales A, Rodríguez-Cabezas ME, Reyes F, Genilloud O, Vicente F, Gálvez J. High-Throughput Screening Platform for the Discovery of New Immunomodulator Molecules from Natural Product Extract Libraries.J. Biomol. Screen. 2016, 21(6): 567-78. Abstract

Pérez-Victoria I, Martín J, Reyes F. Combined LC/UV/MS and NMR strategies for the dereplication of marine natural products. Planta Med 2016, 82: 857–871. Full paper

De Pedro N, Cantizani J, Ortiz-López FJ, González-Menéndez V, Cautain B, Rodríguez L, Bills GF, Reyes F, Genilloud O and Vicente F. Protective Effects of Isolecanoric Acid on Neurodegenerative Diseases. Neuropharmacology 2016, 101: 538-548. Abstract

Pérez-Moreno G, Cantizani J, Sánchez-Carrasco P, Ruiz-Pérez LM, Martín J, El Aouad N, Pérez-Victoria I, Tormo JR, González V, González I, De Pedro N, Reyes F, Genilloud O, Vicente F, González-Pacanowska D. Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products. PLoS ONE 2016, 11(1): e0145812 Abstract

Jaspars, De Pascale D, Andersen JH, Reyes F, Crawford AD, Iannora A. The Marine Biodiscovery Pipeline and Ocean Medicines of Tomorrow. J. Mar. Biol. Assoc. U.K. 2016, 96: 151-158. Full paper

Pascual J, Blanco S, García-López M, García-Salamanca A, Bursakov SA, Genilloud O, Bills OF, Ramos JL, van Dillewijn P. Assessing Bacterial Diversity in the Rhizosphere of Thymus zygis Growing in the Sierra Nevada National Park (Spain) through Culture-Dependent and Independent Approaches.PLoS ONE 2016, 11: e0146558. Abstract

Parra Millán R, Jiménez Mejías ME, Sánchez Encinales V, Ayerbe Algaba R, Gutiérrez Valencia A, Pachón Ibáñez ME, Díaz C, Pérez del Palacio J, López Cortés LF, Pachón J, Smani Y. Efficacy of Lysophosphatidylcholine in Combination with Antimicrobial Agents against Acinetobacter baumannii in Experimental Murine Peritoneal Sepsis and Pneumonia Models.Antimicrob Agents Chemother 2016, 60: 4464–4470.2. Abstract

Fernández-Cruz ML, Martín-Cabrejas I, Pérez-del Palacio J, Gaya P, Díaz-Navarro C, Navas JM, Medina M, Arqués JL. In vitro toxicity of reuterin, a potential food biopreservative.Food Chem Toxicol 2016, 96: 155–159.5. Abstract

Ríos Peces S, Díaz Navarro C, Márquez López C, Caba O, Jiménez-Luna C, Melguizo C, Prados JC, Genilloud O, Vicente Pérez F, Pérez del Palacio J. Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma.J Biomol Screen 2016: 1087057116671490.8. Abstract

N’Ait Ousidi A, Ait Itto MY, Auhmani A, Barakate M, Riahi A, Ben El Ayouchia H, Anane H, El Aouad N, De La Cruz M, Díaz C, Vicente F. Synthesis, theoretical and biological studies of some novel Monoterpenic thiazolidin-4-ones. IOSR Journal of Applied Chemistry. Volume 9, Issue 11 Ver. II 2016, 52-61. Full paper

Painter RE, Adam GC, Arocho M, DiNunzio E, Donald RG, Dorso K, Genilloud O, Gill C, Goetz M, Hairston NN,Murgolo N, Nare B, Olsen D.B, Powles M, Racine F, Su J, Vicente F, Wisniewski D, Xiao L, Hammond M, Young K. Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin. Chem Biol. 2015, 22(10): 1362-73 Abstract

Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, De Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA. Hitting the Caspofungin Salvage Pathway of Human-Pathogenic Fungi with the Novel Lasso Peptide Humidimycin (MDN-0010). Antimicrob Agents Chemother. 2015, 59 (9): 5145-53. Full paper

Muñoz-Sáeza E, De Munck Garcíab S, Arahuetes Porterob RM, Vicente F, Ortiz-López FJ, Cantizani J, Gómez Miguel B. Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). Neuroscience Letters 2015, 593: 83–89. Abstract

Molina-Santiago C, Udaondo Z, Daddaoua A, Roca A, Martín J, Pérez-Victoria I, Reyes F, Ramos JL. Efflux pump deficient mutants as a platform to search for microbes that produce antibiotics. Microb. Biotechnol. 2015, 8: 716-725. Abstract

Tormo JR, Oves D, Lacret D, Moreno C, DeLa Cruz M, Díaz C, González I, Martín J, Pérez-Victoria, Vicente F, Reyes F, Genilloud O. Marine natural products drug discovery from actinomycetes at Fundacion MEDINA. Planta Medica 2015, 81:11. Abstract

Cautain B, De Pedro N, Schulz C, Pascual J, Sousa TS, Martin J, Pérez-Victoria I, Asensio F, González I, Bills G.F, Reyes F, Genilloud O, Vicente F Identification of the lipodepsipeptide MDN-0066, a novel inhibitor of VHL/HIF pathway produced by a new Pseudomonas species.  PLOS ONE 2015, 10(5): e0125221 Abstract

Figueroa L, Jiménez C, Rodríguez J, Areche C, Chávez R, Heríquez M, De la Cruz M, Díaz C, Segade Y, Vaca I.  3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus. J. Nat Prod. 2015, 78 (4): 919–923 - Abstract

Ortiz-López FJ, Monteiro MC, González-Menéndez V, Tormo JR, Genilloud O, Bills GF, Vicente F, Zhang C, Roemer T, Singh SB, Reyes F. Cyclic Colisporifungin and Linear Cavinafungins, three Antifungal Lipopeptides Isolated from Colispora cavincola. J. Nat. Prod. 2015, 78 (3): 468–475 - Abstract

Pascual J, García-López M, Bills GF, Genilloud O Pseudomonas granadensis sp. nov., a new bacterial species isolated from the Tejeda, Almijara and Alhama Natural Park, Granada, Spain. Int. J. Syst. Evol. Microbiol. 2015, 65: 625-632 - Asbtract

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. ACS Infect. Dis. 2015, 1: 59-72 - Full Paper

Cautain B, De Pedro N, Reyes F, Link W  Image-Based Identification of Nuclear Export Inhibitors from Natural Products. Methods Mol. Biol. 2015, 1270: 307-319 - Abstract

Lacret R, Oves-Costales D, Gómez C, Díaz C, de la Cruz M, Pérez-Victoria I,  Vicente F, Genilloud O, Reyes F New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis. Mar. Drugs 2015, 13: 128-140 - Full Paper

Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo J R, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez L M, Navarro M, Gamarro F, González-Pacanowska D High throughput screening platform for Natural Product-based drug discovery against three Neglected Tropical Diseases: human African trypanosomiasis, leishmaniasis and Chagas disease. J. Biomol. Screen. 2015, 20: 82-91 - Abstract

Perez J, Díaz C, Asensio F, Palafox A, Genilloud O, Vicente F A Novel In Vitro Approach for Simultaneous Evaluation of CYP3A4 Inhibition and Kinetic Aqueous Solubility. J. Biomol. Screen. 2015, 20(2): 254-264 - Abstract

Cautain B, Hill R, de Pedro N, Link W Components and regulation of nuclear transport processes. FEBS J. 2015, 282(3): 445-462 - Full Paper


Castillo Correa FJ, De Pedro N, Rodriguez Quesada L, Oves Costales D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014; 50 supplement: 6-24

Cantizani J, Ortiz J, Ravipati AS, Rodrigueza L, Cautain B, Zhang L, Reddy N, Nath CE, Vicente F, De Pedro N., and Koyyalamudi SR Screening for Natural Inhibitors in Chinese medicinal plants against Glycogen Synthase Kinase 3β (GSK-3β) Pharmacologia 2014, 5: 205-214

Ondeyka JG, Smith SK, Zink DL, Vicente F, Basilio A, Bills GF, Polishook JD, Garlisi C, Mcguinness D, Smith E, Qiu H, Gill CJ, Donald RGK, Phillips JW, Goetz MA, Singh SB Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin. J. Antibiot 2014, 67(7): 527-531

Castillo FJ, De Pedro N, Rodriguez L, Oves D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B. Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014, 50 supplement: 6-24. Abstract

Castillo FJ, De Pedro N, Rodriguez L, Oves D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B. Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014, 50 supplement: 6-24. Abstract

Genilloud O The re-emerging role of microbial natural products in antibiotic discovery. Antoine van Leeuwenhoek 2014, 106: 173-188

Castillo FJ, De Pedro N, Rodriguez L, Oves D, Tormo JR, Martin J, Reyes F, Genilloud O, Vicente F, Link W, Cautain B. Discovery of novel inhibitor of FOXO nuclear–cytoplasmic shuttling from natural products of marine origin. European Journal of Cancer Nov 2014, 50 supplement: 6-24. Abstract

Martín-Rodríguez A J, Reyes F, Martín J, Pérez-Yépez J, León-Barrios M, Couttolenc A, Espinoza C, Trigos Á, Martín V, M. Norte, Fernández J J Inhibition of Bacterial Quorum Sensing by Extracts from Aquatic Fungi: First Report from Marine Endophytes. Mar. Drugs 2014, 12(11): 5503-5526 - Full Paper

Guimarães L A, Jimenez P C, Sousa T da S, Freitas H P S, Rocha D D, Wilke D V, Martín J, Reyes F, Pessoa O D L, Costa-Lotufo L V Chromomycin A2 induces autophagy in melanoma cells Mar. Drugs 2014, 12(12): 5839-55 - Full Paper

Martín J, Crespo G, González-Menéndez V, Pérez-Moreno G, Sánchez-Carrasco P, Pérez-Victoria I, Ruiz-Pérez L M, González-Packanowska D, Vicente F, Genilloud O, Bills G F, Reyes F  MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodiiJ. Nat. Prod. 2014, 77(9): 2118-23. - Abstract

Pascual J, García-López M, Carmona C, da S. Sousa T, de Pedro N, Cautain B, Martín J, Vicente F, Reyes F, F. Bills G, Genilloud O Pseudomonas soli sp. nov., a novel producer of xantholysin congeners. Syst. Appl. Microbiol 2014, 37(6): 412-6 - Abstract

González-Menéndez V, Asensio F, Moreno C, de Pedro N, Monteiro MC, de la Cruz M, Vicente F, Bills G, Reyes F, Genilloud O & Tormo JR Assessing the effects of adsorptive polymeric resin additions on fungal secondary metabolite chemical diversity. Micology 2014, 5(3): 179-191 - Full Paper

Montiel R, Martín-Cabrejas I, Langa S, El Aouad N, Arqués J L, Reyes F, Medina M. Antimicrobial activity of reuterin produced by Lactobacillus reuteri on Listeria monocytogenes in cold-smoked salmon.Food Microbiol. 2014, 44: 1-5 - Abstract

Almeida C, El Aouad N, Martín J, Pérez-Victoria I, González-Menéndez V, Platas G, de la Cruz M, Monteiro MC, de Pedro N, Bills GF, Vicente F, Genilloud O, and Reyes F Graminin B, a furanone from the fungus Paraconiothyrium sp. J Antibiot 2014, 67: 421-423 - Abstract

Singh S, Ondeyka J, Buevich A, Williamson R, Zink D, Polishook J, Occi J, Vicente F, Basilio A, Bills G, Donald R, Phillips J, Goetz M Isolation, Structure Elucidation and Biological Activity of Altersolanol P using Staphylococcus aureus Fitness Test Based Genome-wide Screening. J. Nat. Prod. 2014, 77(3): 497-502

Siles JA, Pascual J, González-Menéndez V, Sampedro I, García-Romera I, Bills GF  Short-term dynamics of culturable bacteria in a soil amended with biotransformed dry olive residue. Syst Appl Microbiol 2014, 37(2): 113-20

Siles JA, González-Menéndez V, Platas G, Sampedro I, García-Romera I, Bills GF Effects of Dry Olive Residue Transformed by Coriolopsis floccosa (Polyporaceae) on the Distribution and Dynamic of a Culturable Fungal Soil Community. Microb Ecol 2014, 67(3): 648-58

Hill R, Cautain B, de Pedro N & Link W  Targeting Nucleocytoplasmic Transport in Cancer Therapy. Oncotarget 2014, 5(1): 11-28 - Abstract

Castelli MV, Butassi C, Monteiro MC, Svetaz LA, Vicente F, Zacchino SA Novel antifungal agents: a patent review (2011 - 2014), Exp Op Ther Pat: 24 (3): 1-16 - Abstract

Cautain B, de Pedro N, Murillo Garzón V, Muñoz de Escalona M, González Menéndez C, Tormo JR, Martin J, El Aouad N, Reyes F, Asensio F, Genilloud O, Vicente F and Link W A cell-based strategy using high-content imaging for the discovery of novel nuclear export inhibitors from natural products. J Biomol Screen 2014, 19: 57-65

Chen L, Yue Q, Zhang X, Xiang M, Wang C, Li S, Che Y, Ortiz-López FJ, Bills GF, Liu X and An Z Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC Genomics 2013, 14: 339 - Abstract

Gracia AP, Bondoso J, Gaspar H, Xavier JR, Monteiro MC, de la Cruz M, Oves-Costales D, Vicente F, Lage OM Antimicrobial Activity of Heterotrophic Bacterial, Communities from the Marine Sponge Erylus discophorus (Astrophorida, Geodiidae). Plos One 2013, 8: 11, e78992 - Abstract

Cautain B, de Pedro N, Muñoz de Escalona M, Tormo JR, Genilloud O, Vicente F HCS Strategy Targeting Dysregulation Of The VHL/HIF Pathway For Drug Discovery. Adv Biosci and Biotechnol 2013, 4: 398-405 - Abstract

Singh SB, Zhang C, Zink DL, Herath K, Ondeyka J, Masurekar P, Jayasuriya H, Goetz MA, Tormo JR, Vicente F, Martín J, González I, Genilloud O Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening. J Antibiot 2013, 66: 599-607 - Abstract

Audoin C, Bonhomme D, Ivanisevic J, de la Cruz M, Cautain B, Monteiro MC, Reyes F, Rios L, Perez T and Thomas OP Balibalosides, an Original Family of Glucosylated Sesterterpenes Produced by the Mediterranean Sponge Oscarella balibaloi. Mar Drugs 2013, 11: 1477-1489 - Abstract

Martín MJ, Coello L, Fernández R, Reyes F, Rodríguez A, Murcia C, Garranzo M, Mateo C, Sánchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, and Cuevas C Isolation and First Total Synthesis of PM050489 and PM060184, Two New Marine Anticancer Compounds. J Am Chem Soc 2013, 135: 10164-10171 - Abstract

Palomo S, González I, Martín J, de la Cruz M, Vicente F, Reyes F, Tormo JR, Anderson M, Hill RT, Genilloud O Sponge-derived Kocuria and Micrococcus spp. as new sources of thiazolylpeptide antibiotics. Mar Drugs 2013, 11: 1071-1086 - Abstract

Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de la Cruz M, Monteiro MC, Melguizo A, Jiménez E, Vicente F Anti-fungal and anti-bacterial activities of ethanol extracts of selected traditional Chinese medicinal herbs. Asian Pacific J Trop Med 2013, 6(9): 673-81 - Abstract

Sheo B. Singh John Ondeyka, Harris G, Herath K, Zink D, Vicente F, Bills G, Collado J, Platas G, González de Val A, Martin J, Reyes F, Wang H, Nielsen Kahn J, Galuska S, Giacobbe R, Abruzzo G, Roemer T, Xu D. Isolation, structure and biological activity of a cyclic lipodepsipeptide phaeofungin from a Phaeosphaeria sp. using the genome-wide Candida albicans Fitness Test.  J Nat Prod 2013, 76: 334-345 - Abstract

García E, Alonso A, Platas G and Sacristán S. The endophytic mycobiota of Arabidopsis thaliana. Fungal divers 2013, 60: 71-89 - Abstract

de Pedro N, Cautain B, Melguizo A, Vicente F, Genilloud O, Peláez F, Tormo JR Mitochondrial complex I inhibitors, acetogenins, induce 5 HepG2 cell death through the induction of the complete 6 apoptotic mitochondrial pathway. J Bioenerg Biomembr 2013, 45: 153-164 - Abstract

de Pedro Montejo N, Cautain B, Melguizo A, Cortes D, Vicente F, Genilloud O, Tormo JR, Peláez F Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I. J Bioenerg Biomembr 20013, 45(1-2): 145-152 - Abstract

Martin J, da S Sousa T, Crespo G, Palomo S, Gonzalez I, Tormo JR, de la Cruz M, Anderson M, Hill RT, Vicente F, Genilloud O, Reyes F Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris. Mar Drugs 2013, 11: 387-98 - Abstract

Ravipati AS, Zhang L, Koyyalamudi SR, Jeong SC, Reddy N, Bartlett J, Smith PT, de Pedro N, Melguizo A, Cantizani J, Asensio F, Vicente F Anti-proliferative activities of selected Chinese medicinal herbs against human cancer cell lines. Phytopharmacology 2013, 4(2): 206-219 - Abstract

Baral HO, Galán R, Platas G & Tena R Phaeohelotium undulatum comb. nov. and Phaeoh. succineoguttulatum sp. nov., two segregates of the Discinella terrestris aggregate found under Eucalyptus in Spain: taxonomy, molecular biology, ecology and distribution.  Mycosystema 2013, 32(3): 386-428 - Abstract

Pérez J, Díaz C, Salado IG, Pérez DI, Peláez F, Genilloud O, Vicente F Evaluation of the effect of compound aqueous solubility in cytochrome P450 inhibition assays. Adv Biosci Biotechnol 2013, 4: 628-639 - Abstract

Singh SB,  Goetz MA,  Smith SK,  Zink DL,  Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, de la Cruz M, Martín J , Vicente F, Genilloud O,  Donald RGK,  Phillips JW Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities. Bioorg Med Chem letters 2012, 22: 7127-7130 - Abstract

Fernández-Acero T, Rodríguez-Escudero I, Vicente F,  Monteiro MC, Tormo JR, Cantizani J, Molina M,  Cid VJ A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors. J Biomol Screening 2012, 17(8): 1018-1029 - Abstract

Vicente MF, Bills G, Reyes F, Genilloud O Fundación MEDINA - Investigación en Terapias Innovadoras a partir de Productos Naturales aislados de Microorganismos. Especial Microbiología Industrial y Biotecnología Microbiana. Actualidad SEM 2012,  53: 32-35 - Article

Kai M, González I, Genilloud O, Singh SB, Svatoš A Direct mass spectrometric screening of antibiotics from bacterial surfaces using liquid extraction surface analysis. Rapid Commun. Mass Spectrom. 2012, 26(20): 2477-2482 - Abstract

Genilloud O Current Challenges in the Discovery of Novel Antibacterials from Microbial Natural Products. Recent Pat Antiinfect Drug Discov.  2012, 7(3): 189-204(16) - Abstract

Bills GF, Dombrowski AW and Goetz MA The “FERMEX” method for metabolite-enriched fungal extracts. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.). Meth Mol Biol 2012, 944(5): 79-96 - Abstract

Bills GF, González-Menéndez V, Martin J, Platas G, Fournier J, Peršoh D and Stadler M. Hypoxylon pulicicidumsp. nov. (Ascomycota, Xylariales), a Pantropical Insecticide-Producing Endophyte. PLOS One 2012, 7: e46687 - Abstract

Bills GF, González-Menéndez V and Platas G Kabatiella bupleuri sp. nov. (Dothideales), a pleomorphic epiphyte and endophyte of the Mediterranean plant, Bupleurum gibraltarium (Apiaceae). Mycologia 2012, 104: 962-973 - Abstract

Cueva C, Garcia Ruiz A, González-Rompinelli Bartolomé EB, Martín-Álvarez PJ, Salazar O, Vicente MF,  Bills G and  Moreno-Arribas V Degradation of biogenic amines by vineyard ecosystem fungi. Potential use in winemaking. J Appl Microbiol 2012, 112: 672-682 - Abstract

De la Cruz M, Martín J, González-Menéndez V,  Pérez-Victoria I, Moreno C, Tormo JR, El Aouad N, Guarro J, Vicente F, Reyes F and Bills GF Chemical and physical modulation of antibiotic activity in Emericella species. Chem Biodiv 2012, 9: 1095-1113 - Abstract

El Aouad N, Pérez-Moreno G, Sánchez P, Cantizani J, Ortiz-López FJ, Martín J, González-Menéndez V, Ruiz-Pérez LM, González-Pacanowska D, Vicente F, Bills G and Reyes F Lasionectrin, a Naphthopyrone from a Lasionectria sp. J Nat Prod 2012, 75: 1228-1230 - Abstract

Genilloud O and Vicente F Novel approaches to exploit natural products from microbial resources. InDrug Discovery from Natural Products, Eds. O. Genilloud and F. Vicente, RSC series. 2012, Ch. 11: 221-248 - Book

Genilloud O Genus Micromonospora. In Bergey's Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012, vol 5 B: 1039-1057 - Book

Genilloud O Suborder XI. Micromonosporineae and The family Micromonosporaceae. In Bergey's Manual of Systematic Bacteriology, Volume 5 (Actinobacteria) eds. Busse H-J, Goodfellow M, Kämpfer P, Ludwig W, Suzuki K and Whitman WB. 2012, vol 5 B: 1035-1038 - Book

Herath K, Jayasuriya H, Zink DL,  Sigmund J, Vicente F, de la Cruz M,  Basilio A, Bills GF, Polishook JD,DonaldR, Phillips J,  Goetz M and Singh SB Isolation, structure elucidation and antibacterial activity of methiosetin, a new tetramic acid from a tropical sooty mold (Capnodium sp.). J Nat Prod 2012, 75: 420–424 - Abstract

Monteiro MC, de la Cruz M, Cantizani J, Moreno C, Tormo JR, Mellado E,  de Lucas JR, Asensio F,  Valiante V, Brakhage AA, Latgé J-P, Genilloud O and Vicente F A New Approach to Drug Discovery: High-Throughput Screening of Microbial Natural Extracts against Aspergillus fumigatus Using Resazurin. J Biomol Screen 2012, 17: 542-549 - Abstract

Pérez-Victoria I, Martín J, González-Menéndez V, de Pedro N, El Aouad N, Ortiz-López FJ, Tormo JR, Platas G, Vicente F, Bills GF, Genilloud O, Goetz MA and Reyes F Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica. J Nat Prod 2012, 75: 1210-1214 - Abstract

Sánchez-Hidalgo M, Pascual J, de la Cruz M, Martín J, Kath GS, Sigmund JM, Masurekar P, Vicente F, Genilloud O and Bills GF Prescreening bacteria colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system. Antonie van Leeuwenhoek 2012, 102: 361-374 - Abstract

Sánchez Márquez S, Bills GF , Herrero N and Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecol 2012, 5: 289–297 - Abstract

Tormo, JR, Asensio, FJ and Bills (GF) Manipulating filamentous fungus chemical phenotypes by growth in nutritional arrays. In Methods in Molecular Biology Fungal Secondary Metabolism: Methods and Protocols, Nancy P. Keller and Geoffrey Turner (eds.), Met Mol Biol 2012, 944 (4): 59-78 - Abstract

Oves-Costales D and Challis GL Mining microbial genomes for metabolic products of cryptic pathways. InDrug Discovery from Natural Products, Eds. Genilloud O and Vicente F, RSC series 2012, 8: 140-158 - Abstract

El Aouad N,  Monteiro MC, Pérez-Moreno G, Cantizani J, Moreno C, Martín J, González I, Vicente F, Genilloud O,  González-Packanowska D, Tormo JR,  Reyes F. A new natural Pepstatin from Kitasatospora sp. (Actinomycetales) Planta Medica. 2011, 77: 1345

Ferrer M, Guazzaroni ME, Richter M, García-Salamanca A, Yarza P, Suárez-Suárez A, Solano J, Alcaide M, van Dillewijn P, Molina-Henares MA, López-Cortés N, Al-Ramahi Y, Guerrero C, Acosta A, de Eugenio LI, Martínez V, Marques S, Rojo F, Santero E, Genilloud O, Pérez-Pérez J, Rosselló-Móra R, Ramos JL Taxonomic and Functional Metagenomic Profiling of the Microbial Community in the Anoxic Sediment of a Sub-saline Shallow Lake (Laguna de Carrizo, Central Spain). Microb Ecol 2011, 62: 824-37 - Abstract

Cueva C, Moreno-Arribas V, Bartolomé B, Salazar O, Vicente MF & Bills GF  Antibiosis of vineyard ecosystem fungi against food-borne microorganisms. Res Microbiol 2011, 162: 1043–1051 - Abstract

Torres MS, Tadych M, White JF Jr. & Bills GF Dilution-to-extinction cultivation of endophytic fungi and isolation and detection of grass endophytic fungi in different plant parts, Isolation and identification of fungal endophytes. Pgs. 13-18, 153-164. In: Prospects and Applications for Plant-Associated Microbes. A Laboratory Manual, Part B: Fungi. Editors Pirttilä AM & Sorvari S. BioBien Innovations 2011, Paimio, Finland

Pérez-Victoria I, Pérez-Victoria FJ, Roldán-Vargas S, García-Hernández R, Carvalho  Santiago Castanys L, Gamarro F, Morales JC, Pérez-Victoria JM, Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry. Bioenergetics 2011, 1808: 717–726 - Abstract

Sánchez Márquez S, Bills GF & Zabalgogeazcoa I Fungal species diversity in juvenile and adult leaves of Eucalyptus globulus from plantations affected by Mycosphaerella leaf disease. Ann Appl Biol 2011, 158: 177-187 - Article

Campos-Salinas J, Cabello-Donayre M, García-Hernández R, Pérez-Victoria I, Castanys S, Gamarro F and Pérez-Victoria JM A new ATP binding cassette protein is involved in intracellular haem trafficking in Leishmania. Molecular Microbiology 2011, 79(6): 1430-44- Abstract

Genilloud O, González I, Salazar O, Martín J, Tormo JR, Vicente F Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol, 38: 375–389 - Abstract

Roemer T, Xu D, Singh SB, Parish CA, Harris G, Wang H, Davies JE and Bills GF Confronting the Challenges of Natural Product-Based Antifungal Discovery. Chem Biol 2011, 18: 148-164 - Abstract

Xu D, Ondeyka J, Harris GH, Zink D, Nielsen Kahn J, Wang H, Bills G, Platas G, Wang W, Szewczak AA, Liberator P, Roemer T, and Singh SB Isolation, Structure, and Biological Activities of Fellutamides C and D from an Undescribed Metulocladosporiella (Chaetothyriales) Using the Genome-Wide Candida albicans Fitness Test. J Nat Prod 2011, 74 (8): 1721-1730 - Abstract

Gabriel Moreno, Maria-Natividad Blanco, Julia Checa,  Gonzalo Platas,  Fernando Peláez Taxonomic and phylogenetic revision of three rare irpicoid species within the Meruliaceae. Mycol Progress 2011, 10: 481-491 - Abstract

Peláez F, Collado J, Platas G, Overy DP, Martín J, Vicente F, González del Val A, Basilio A, de la Cruz M, Tormo JR, Fillola A, Arenal F, Villareal M, Rubio V, Baral HO, Galán R and Bills GF The phylogeny and intercontinental distribution of the pneumocandin-producing anamorphic fungus Glarea lozoyensis. Mycology 2011, 2: 1–17 - Abstract

Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, Lee S, Skwish S, de la Cruz M, Martín J, Vicente F, Genilloud O, Lu J, Painter RE, Young K, Overbye K, Donald RGK, and Singh SB Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus. Chem Biol 2011, 18: 955–965 - Abstract

Sánchez Márquez S, Bills GF, Herrero N, Zabalgogeazcoa I Non-systemic fungal endophytes of grasses. Fungal Ecology 2011 , 5(3): 289–297 - Abstract

Tijerino A, Cardoza RE, Moraga J, Malmierca MG, Vicente F, Aleu J, Collado IG, Gutiérrez S, Monte E, Hermosa R Overexpression of the trichodiene synthase gene tri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum. Fungal Genet Biol 2011, 48: 285–296 - Abstract

El Aouad N, Ortiz-Lopez J, Martín J, Tormo JR, Goetz M and Genilloud O. New semi –automated method for the creation of a microbial fraction collection developed at Fundación MEDINA. Planta Medica 2010, 76: 1319 - Abstract

Ayers S, Zink DL, Mohn K, Powell JS, Brown CM, Bills G, Grund A, Thompson D and Singh SB Anthelmintic constituents of Clonostachys candelabrum. J  Antibiot, 2010, 63: 119-122 - Abstract

Cueva C, Victoria Moreno-Arribas M, Martín-Alvarez PJ, Bills G, Vicente F, Basilio A, Lopez Rivas C, Requena T, Rodriguez JM and Bartolome B Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria. Res Microbiol 2010, 161: 372-382 - Abstract

Duetz W, Chase M and Bills G Miniaturization of fermentations. In Manual of Industrial Microbiology and Biotechnology, 3rd ed eds. Demain A, Davies J and Baltz R. pp.99-116. Washington, DC 2010: ASM Press - Book

Goetz MA, Zhang C, Zink DL, Arocho M, Vicente F, Bills GF, Polishook J, Dorso K, Onishi R, Gill C, Hickey E, Lee S, Ball R, Skwish S, Donald RGK, Phillips JW and Singh SB Coelomycin, a highly substituted 2,6-dioxo-pyrazine fungal metabolite antibacterial agent discovered by Staphylococcus aureus fitness test profiling. J Antibiot 2010, 63: 512-518 - Abstract

Márquez SS, Bills GF, Acuna LD and Zabalgogeazcoa I Endophytic mycobiota of leaves and roots of the grass Holcus lanatus. Fungal Diversity 2010, 41: 115-123 - Abstract

Peterson SW, Jurjevic Z, Bills GF, Stchigel AM, Guarro J and Vega FE Genus Hamigera, six new species and multilocus DNA sequence based phylogeny. Mycologia 2010, 102: 847-864 - Abstract

Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Diaz C, Cautain B,   Vicente F, Genilloud O, Reyes F. Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive glycosylated 36-membered polyol macrolides from the marine-derived Streptomyces caniferus CA-271066. Org. Biomol. Chem., 2019 Abstract

Bills G, Overy DP, Genilloud O and Peláez F Contributions of pharmaceutical antibiotic and secondary metabolite discovery to the understanding of microbial defense and antagonism. In Defensive Mutualism in Microbial Symbiosis eds. White JF and Torres MS. pp.257-297 Boca Raton, USA 2010: CRC Press - Book

Bills GF, Martín J, Collado J, Platas G, Overy D, Tormo JR, Vicente F, Verkleij G and Crous P Measuring the distribution and diversity of antibiosis and secondary metabolites in the filamentous fungi. Society of Industrial Microbiology News 2009, 59: 133-147 - Abstract

Bills GF, Platas G, Overy D, Collado J, Fillola A, Jiménez MR, Martín J, Val AGd, Vicente F, Tormo JR, Peláez F, Calati K, Harris G, Parish C, Xu D and Roemer T Discovery of the parnafungins, antifungal metabolites that inhibit mRNA poly-adenylation, from the Fusarium larvarum complex and other hypocrealean fungi. Mycologia 2009, 101: 445-469 - Abstract

Blanco MN, Moreno G, Checa J, Platas G and Peláez F Taxonomic and phylogenetic revision of Coniophora arachnoidea, C. opuntiae, and C. prasinoides. Mycotaxon 2009, 108: 467-477 - Abstract

Donald RGK, Skwish S, Forsyth RA, Anderson JW, Zhong T, Burns C, Lee S, Meng X, LoCastro L, Jarantow LW, Martin J, Lee SH, Taylor I, Robbins D, Malone C, Wang LS, Zamudio CS, Youngman PJ and Phillips JW  AStaphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds. Chem Biol 2009, 16: 826-836 - Abstract

Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu DM, Roemer T and Singh SB (2009) Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp. Bioorg Med Chem 2009, 17: 1361-1369 - Abstract

Ondeyka J, Harris G, Zink D, Basilio A, Vicente F, Bills G, Platas G, Collado J, González A, de la Cruz M, Martin J, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Jiang B, Xu DM, Roemer T and Singh SB Isolation, structure elucidation, and biological activity of virgineone from Lachnum virgineum using the genome-wide Candida albicans fitness fest. J Nat Prod 2009, 72: 136-141

Overy D, Calati K, Kahn JN, Hsu M-J, Martin J, Collado J, Roemer T, Harris G and Parish CA Isolation and structure elucidation of parnafungins C and D, isoxazolidinone-containing antifungal natural products. Bioorg Med Chem Lett  2009, 19: 1224-1227 - Abstract

Parish CA, de la Cruz M, Smith SK, Zink D, Baxter J, Tucker-Samaras S, Collado J, Platas G, Bills G, Díez MT, Vicente F, Peláez F and Wilson K Antisense-guided isolation and structure elucidation of pannomycin, a substituted cis-decalin from Geomyces pannorum. J Nat Prod 2009, 72: 59-62 - Abstract

Platas G, González V, Collado J, Martín J, Montes C and Peláez F Ascription of poorly defined taxa to taxonomic entities using molecular phylogenies: a case study on Nodulisporium sp producers of nodulisporic acid. Mycotaxon 2009, 109: 443-460 - Abstract

Rojas JL, Martín J, Tormo JR, Vicente F, Brunati M, Ciciliato I, Losi D, Trappen SV, Mergaert J, Swings J, Marinelli F and Genilloud O Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites. Marine Genomics 2009, 2: 33-41 - Abstract

Singh SB, Jayasuriya H, Zink D, Basilio A, Vicente F, Collado J, Bills G, Lee Goldman M, Motyl M, Huber J, Dezeny G & Byrne K Discovery and antibacterial activity of glabramycin A-C from Neosartorya glabra by an antisense strategy. J Antibiot, 2009, 62: 265-269 - Abstract

Singh SB, Genilloud O and Peláez F NP structural diversity II - Secondary metabolite sources, evolution and selected molecular structures: Terrestrial micro-organisms – bacteria. In Comprehensive Natural Products Chemistry II eds. Moore, B and CrewsP., 2009, pp.109-140. UK: Elsevier - Book

Singh SB, Zink DL, Dorso K, Motyl M, Salazar O, Basilio A, Vicente F, Byrne KM, Ha S and Genilloud O Isolation, structure, and antibacterial activities of lucensimycins D-G, discovered fromStreptomyces lucensis MA7349 using an antisense strategy. J Nat Prod 2009, 72: 345-352 - Abstract

Vicente F, Basilio A, Platas G, Collado J, Bills GF, González del Val A, Martín J, Tormo JR, Harris GH, Zink DL, Justice M, Kahn JN and Peláez F Distribution of the antifungal agents sordarins across filamentous fungi. Mycol Res 2009, 113: 754-770 - Abstract

Zhang C, Ondeyka JG, Zink DL, Basilio A, Vicente F, Salazar O, Genilloud O, Dorso K, Motyl M, Byrne K and Singh SB Discovery of okilactomycin and congeners from Streptomyces scabrisporus by antisense differential sensitivity assay targeting ribosomal protein S4. J Antibiot 2009, 62: 55-61 - Abstract

Zhang CW, Ondeyka JG, Zink DL, Basilio A, Vicente F, Collado J, Platas G, Huber J, Dorso K, Motyl M, Byrne K and Singh SB Isolation, structure and antibacterial activity of pleosporone from a pleosporalean ascomycete discovered by using antisense strategy. Bioorg Med Chem 2009, 17: 2162-2166 - Abstract

2020

Rotter A, Bacu A, Barbier M, Bertoni F, Bones A M, Cancela M L, Carlsson J, Carvalho M F, Cegłowska M, Dalay M C, Dailianis T, Deniz I, Drakulovic D, Dubnika A, Einarsson H, Erdoğan A, Eroldoğan O T, Ezra D, Fazi S,FitzGerald R J, Gargan L M, Gaudêncio S P, DeNardis N I, Joksimovic D, Kataržytė M, Kotta J, Mandalakis M, Matijošytė I, Mazur-Marzec H, Massa-Gallucci A, Mehiri M, Nielsen S L, Novoveská L, Overlingė D, Portman M E, Pyrc K, Rebours C, Reinsch T, Reyes F, Rinkevich B, Robbens J, Rudovica V, Sabotič J, Safarik I, Talve S, Tasdemir D, Schneider X T, Thomas OP, Toruńska-Sitarz A, Varese G C, Vasquez . A new network for the advancement of marine biotechnology in Europe and beyond. Front. Mar. Sci., 2020; 7:278. Abstract

Martín-Blázquez A, Jiménez-Luna C,Díaz C, Martínez-Galán J, Prados J, Vicente F, Melguizo C, Genilloud O, Pérez del Palacio J, Caba O. Discovery of Pancreatic Adenocarcinoma Biomarkers by Untargeted Metabolomics. Cancers, 2020, 12(4), 1002. Abstract

Berenguel Hernández A M., De la Cruz M, Alcázar-Fabra M, Prieto-Rodríguez A, Sánchez-Cuesta A, Martin J, Tormo J R, Rodríguez-Aguilera J C, Cortés-Rodríguez A B, Navas P, Reyes F, Vicente F, Genilloud O, Santos-Ocaña C. Design of high-throughput screening of natural extracts to identify molecules bypassing primary coenzyme Q deficiency in Saccharomyces cerevisiae. SLAS Discov., 2020, 25, 299-309. Abstract

Salamanca-Fernández E,Rodríguez-Barranco M, Arrebola JP, Vela F, Díaz C, Chirlaque M D, Colorado-Yohar S, Jiménez-Zabala A, Irizar A, Guevara M, Ardanaz E, Iribarne-Durán LM, Pérez del Palacio J, Olea N, Agudo A, Sánchez MJ. Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors. Environmental Research,2020, 182, 109012. Abstract

Lauritano C, Martínez K A, Battaglia P, Granata A, De la Cruz M, Cautain B, Martín J, Reyes F, Ianora A, Guglielmo L. First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species. Sci Rep., 10, 4929 (2020).  Abstract

Diogo Santos J, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez I, Tormo J R, Martin J, Vicente MF, Lage OM. Diketopiperazines and other bioactive compounds from bacterial symbionts of marine sponges. Antonie van Leeuwenhoek, (2020). doi: 10.1007/s10482-020-01398-2.   Abstract

Sánchez-Hidalgo M, Martín J, Genilloud O. Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Lasso Peptide Humidimycin, a Caspofungin Activity Potentiator. Antibiotics, 2020, 9(2), 67.  Abstract

Georgousaki K, Tsafantakis N, Gumeni S, Lambrinidis G, González-Menéndez V, Tormo JR, Genilloud O, Trougakos IP, Fokialakis N. Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules. Molecules, 2020, 25(3), 666. Abstract

Fang Q , Maglangit F , Wu L, Ebel R, Kyeremeh K, Andersen JH, Annang F, Pérez-Moreno G,Reyes F, Deng H. Signalling and Bioactive Metabolites from Streptomyces sp. RK44, Molecules, 2020, 25(3), 460. Abstract

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Salas JA, Olano C. Generation of new sipanmycin analogues by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway. Appl. Environ. Microbiol., 2020, 86, e02453-19.  Abstract

Georgousaki, K., Tsafantakis, N., Gumeni, S., Gonzalez, I., Andrew Mackenzie, T., Reyes F., Lambert, C., Trougakos, I.P., Genilloud, O., Fokialakis, N., Screening for tyrosinase inhibitors from actinomycetes; Identification of trichostatin derivatives from Streptomyces sp. CA-129531 and scale up production in bioreactor. Bioorg Med Chem Lett., 2020, 15;30(6):126952.  Abstract

Romain Koagne R, Annang F, Cautain B, Martín J, Pérez-Moreno G, Thierry M. Bitchagno G, González-Pacanowska D, Vicente F, Konga Simo I, Reyes F & Tane P. Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae). BMC Complementary Medicine and Therapies, 2020,15;20(1):8.  Abstract

Carretero-Molina D, Ortiz-López F J, Martín J, Oves-Costales D, Díaz C, De la Cruz M, Cautain B, Vicente F, Genilloud O, Reyes F. New Napyradiomycin Analogues from Streptomyces sp. Strain CA-271078. Mar. Drugs, 2020, 18(1), 22.  Abstract

Mazzotta S, Marrugal-Lorenzo J A, Vega-Holm M, Serna-Gallego A, Álvarez-Vidal J, Berastegui-Cabrera J, Pérez del Palacio J, Díaz C, Aiello F, Pachón J,Iglesias-Guerra F,Vega-Pérez J M, Sánchez-Céspedes J. Optimization of piperazine-derived ureas privileged structures for effective antiadenovirus agents. Eur J Med Chem., 2020, 1;185. Abstract

2019

Martín-Blázquez A, Díaz C, González-Flores E, Franco-Rivas D, Jiménez-Luna C, Melguizo C, Prados J, Genilloud O, Vicente F, Caba O, Pérez Del Palacio J. Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer. Sci Rep., 9, 20198 (2019). Abstract

Almeida C, Mackenzie TA, González-Menendez V, De Pedro N, Pérez-Victoria I, Crespo G, Martín J, Genilloud O, Vicente F, Cautain B, Reyes F. Laccaridione C, a Bioactive Polyketide from the Fungus Montagnula sp. PMIO, 2019; 6(02): e57-e62. Abstract

Barúa JE, De la Cruz M, De Pedro N, Cautain B, Hermosa R, Cardoza RE, Gutiérrez S, Monte E, Vicente F, Collado IG. Synthesis of Trichodermin Derivatives and Their Antimicrobial and Cytotoxic Activities. Molecules, 2019, 24, 3811 Abstract

Cabello-Donayre M, Orrego LM, Herráez E, Vargas P, Martínez-García M, Campos-Salinas J, Pérez-Victoria I, Vicente B, Marín JJG, Pérez-Victoria JM. Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite. Cell. Mol. Life Sci., 2019. doi: 10.1007/s00018-019-03258-3.  Abstract

Tejman-Yarden N, Robinson A, Davidov Y, Shulman A, Varvak A, Reyes F, Rahav G, Nissan I. Delftibactin-A, a Non Ribosomal Peptide with Broad Antimicrobial Activity. Front. Microbiol., 10:2377  doi: 10.3389/fmicb.2019.02377.  Abstract

Reina JC, Pérez-Victoria I, Martín J, Llamas I. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar. Drugs, 2019, 17: 494. Abstract

González-Menéndez V, Crespo G, Toro C, Martín J, de Pedro N, Tormo JR, Genilloud O. Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani. Metabolites, 2019, 9: 197. Abstract

Samy MN, Le Goff G, Lopes P, Georgousaki K, Gumeni S, Almeida C, González I, Genilloud O, Trougakos I, Fokialakis N, Ouazzani J. Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. Molecules, 2019, 24: 2239. Abstract

Peyrat L-A, Tsafantakis N, Georgousaki K, Ouazzani J, Genilloud O, Trougakos IP, Fokialakis N. Terrestrial Microorganisms: Cell Factories of  Bioactive Molecules with Skin Protecting  Applications. Molecules, 2019, 24: 1836. Abstract

Georgousaki K, Tsafantakis N, Gumeni S, González-Menéndez V, de Pedro N, Tormo JR, Almeida C, Lambert C, Genilloud O, Trougakos IP, Fokialakis N. Cercospora sp. as a source of anti-aging polyketides targeting 26S proteasome and scale-up production in submerged bioreactor. J Biotechnol., 2019, 301: 88-96. Abstract

Martínez KA, Lauritano C, Druka D, Romano G, Grohmann T, Jaspars M, Martín J, Díaz C, Cautain B, de la Cruz M, Ianora A, Reyes F. Amphidinol 22, a new cytotoxic and antifungal amphidinol from the dinoflagellate Amphidinium carterae. Mar. Drugs, 2019, 17: 385. Abstract

Díaz C, Pérez del Palacio J, Valero-Guillén PL, Mena García P, Pérez I, Vicente F, Martín C, Genilloud O, Sánchez Pozo A, Gonzalo-Asensio J. Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate. ACS Infectious Diseases., 2019, 5: 1317-1326. Abstract

Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Pérez-Moreno G, Gonzalez Martinez I, Tormo JR, Martín JM, Urbatzka R, Vicente FM, Lage OM. Bioactivities and Extract Dereplication of Actinomycetales isolated from Marine Sponges. Front Microbiol., 2019, 10: 727. Abstract

Pérez del Palacio J, Díaz-Navarro C, Martín-Blázquez A, González-Olmedo C, Vergara-Segura N, Algieri F, Rodriguez-Nogales A, González-Tejero MR, Casares-Porcel M, Molero-Mesa J, Rodríguez-Cabez MA. Metabolomic analysis of Lavandula dentata L. and Lavandula stoechas L. extracts by LC-QTOF/MS experiments and multivariate analysis techniques as a chemotaxonomical tool. Plant. Biosyst., 2019, 154:231-240.  Abstract

Butassi E, Svetaz LA, Zhou S, Wolfender JL, G. Cortés JC, Ribas JC, Díaz-Navarro C, Pérez del Palacio J, Vicente F, Zacchino SA. The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera.  Phytomedicine, 2019, 60: 152884.  Abstract

Martín J, Reyes F, Vicente F, Gamboa-Angulo M, Escalante-Réndiz D, De la Rosa García S, Tapia-Tussell R. Molecular Identification of Selected Streptomyces Strains Isolated from Mexican Tropical Soils and their Anti-Candida Activity. Int J. Environ. Res. Public Health, 2019, 16: 1913. Abstract

Khentoul H, Bensouici C, Reyes F, Albanese D, Sarri D, Mekkiou R, Benayache F, Seghiri R, Boumaza O. Chemical constituents and HRESI-MS analysis of an Algerian endemic plant-Verbascum atlanticum Batt.- extracts and their antioxidant activity. Nat. Prod. Res., 2019, 22: 1-5.  Abstract

Guillen PO, Jaramillo KB, Jennings L, de la Cruz M, Cautain B, Reye Fs, Rodríguez J, Thomas OP. Halogenated tyrosine derivatives from the Tropical Eastern Pacific Zoantharians Antipathozoanthus hickmani and Parazoanthus darwini. J. Nat. Prod., 2019, 82: 1354-1360. Abstract

Martínez-Burgo Y, Santos-Aberturas J, Rodríguez-García A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P. Activation of secondary metabolite gene clusters in Streptomyces clavuligerus by the PimM regulator of Streptomyces natalensis. Front. Microbiol., 2019, 10: 580. Abstract

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Caniferolide A, a macrolide from Streptomyces caniferus, attenuates neuroinflammation, oxidative stress, amyloid-beta and tau pathology in vitro. Mol. Pharm., 2019, 16: 1456-1466.   Abstract

Pérez-Victoria I, Oves-Costales D, Lacret R, Martín J, Sánchez-Hidalgo M, Diaz C, Cautain B,   Vicente F, Genilloud O, Reyes F. Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive glycosylated 36-membered polyol macrolides from the marine-derived Streptomyces caniferus CA-271066. Org. Biomol. Chem., 2019, 17:2954-2971.  Abstract

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Martín J, Otero L, Palacios-Gutiérrez JJ, Fernández J, Mohamedi Y, Fontanil T, Salmón M, Cal S, Reyes F, García LA, Gloria Blanco. Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva spMar. Drugs, 2019, 17 (2) : 114. Abstract

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J,  Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M,  Specker E, Bartunek P, Simova S, Les´nikowski Z, Krauss S, Lehtiö L, Bilitewski U, Brönstrup M, Taskén K, Jirgensons A, Lickert H, Clausen MH, Andersen JH, Vicent MJ, Genilloud O, Martinez A, Nazaré M, Fecke W, and Gribbon P. EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS Discover., 2019, 24: 398-413.  Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2019, 33: 66-73 Abstract

Castillo F., Mackenzie T.A., Cautain B. Immunofluorescence Analysis by Confocal Microscopy for Detecting Endogenous FOXO. Link W. (eds) FOXO Transcription Factors. Methods in Molecular Biology, 2019, 1890: 143-149. Abstract

2018

Koagne RR, Annang F, de la Cruz M, Bitchagno GTM, Perez-Victoria I, Konga IS, Vicente F, Reyes F, Tane P. Antibacterial Activity of Flavans from Crinum distichumNatural Product Communications 2018, 13 : 637-1638. Abstract

Genilloud O. Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm? Antibiotics, 2018, 7: 85. Abstract

Calabro K, Chalén BE, Genta-Jouve G, Jaramillo KB, Domínguez C, de la Cruz M, Cautain B, Reyes F, Thomas OP, Rodríguez J. Callyspongidic Acids: Amphiphilic Diacids from the Tropical Eastern Pacific Sponge Callyspongia cf. californicaJ. Nat. Prod., 2018, 81, 2301-2305. Abstract

Rodríguez V, J. Martín, A. Sarmiento-Vizcaíno, M. de la Cruz, L. A. García, G. Blanco, Reyes F. Anthracimycin B, a Potent Antibiotic against Gram-Positive Bacteria Isolated from Cultures of the Deep-Sea Actinomycete Streptomyces cyaneofuscatus M-169. Mar. Drugs2018, 16: 406. Full text

Ortiz-López FJ, Alcalde E, Sarmiento-Vizcaíno A, Díaz C, Cautain B, García, Blanco G, Reyes F. New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157Mar. Drugs, 2018, 16: 371. Abstract

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM. Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitroNeuropharmacology, 2018, 141: 283-295. Abstract

Solanki H, Angulo-Preckler C, Calabro K, Kaur N, Lasserre P, Cautain B, de la Cruz M, Reyes F, Avila C, Thomas OP. Suberitane sesterterpenoids from the Antarctic sponge Phorbas areolatus (Thiele, 1905). Tetrahedron Lett., 2018, 59: 3353-3356. Abstract

Annang F, Pérez-Victoria I, Pérez-Moreno G, Domingo E, González I, Tormo JR, Martín J, Ruiz-Pérez LM, Genilloud O, González-Pacanowska D, Vicente F, Reyes F. MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353. J. Nat. Prod., 2018, 81: 1687-1691. Abstract

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Olano C, Salas JA, Cooperative involvement of glycosyltransferases in the transfer of amino sugars during the biosynthesis of the macrolactam sipanmycin by Streptomyces sp. strain CS149. Appl Environ Microbiol 84:e01462-18. Abstract

Li F, Janussen D, Peifer C, Pérez-Victoria I, Tasdemir D, Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity. Mar. Drugs 2018, 16, 268. Abstract

Lage OM, Ramos MC, Calisto R, Almeida E, Vasconcelos V, Vicente F. Current Screening Methodologies in Drug Discovery for Selected Human Diseases. Marine Drugs. 2018; 16(8):279. Full article

Annang F, Pérez-Victoria I, Appiah T, Pérez-Moreno G, Domingo-Contreras E, Martín J, Machenzie T, Ruiz-Pérez L, González-Packanowska D, Genilloud O, Vicente F, Agyare C, Reyes F. Bioassay-guided isolation of four new antiprotozoal compounds from two Ghanaian mushrooms. Fitoterapia 2018 Jun, 127:341-348. Abstract

González-Menéndez V, Crespo G, De Pedro N, Diaz C, Martín J, Serrano R, Mackenzie TA, Justicia C, González-Tejero MR, Casares M, Vicente F, Reyes F, Tormo JR, Genilloud O. Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents. Nature.com, Scientific Reports, 2018, 8: 9729. Abstract

Almeida C, Silva Pereira C, González-Menéndez V, Bills G, Pascual J, Sánchez-Hidalgo M, Kehraus S, Genilloud O. Unveiling concealed functions of endosymbiotic bacteria harboured in the Ascomycota Stachylidium bicolor. Appl. Environ. Microbiol., 2018, DOI: 10.1128/AEM.00660-18. Abstract

Almeida C, Pérez-Victoria I, González-Menéndez V, de Pedro N, Martín J, Crespo G, Mackenzie T, Cautain B, Reyes F, Vicente F, Genilloud O. Unprecedented non-geminal aliphatic dihalogenation pattern in dichlorinated diaporthins from Hamigera fusca NRRL 35721J. Nat. Prod., 2018, DOI:10.1021/acs.jnatprod.8b00041. Abstract

Sarmiento-Vizcaíno A, Espadas J, Martín J, Braña AF, Reyes F, García LA, Blanco G. Atmospheric precipitations, hailstone and rainwater, as a novel source of Streptomyces producing bioactive natural productsFront. Microbiol., 2018, 9:773. Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Natural product Research, 2018, https://doi.org/10.1080/14786419.2018.1434636. Abstract

Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, Díaz-Navarro C, Pérez-Del Palacio J, García-Fernández M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla-Ortega E. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018 May 1;133:189-201. Abstract

Pachón-Ibáñez ME, Labrador-Herrera G, Cebrero-Cangueiro T, Díaz C, Smani Y, del Palacio JP, Rodríguez-Baño J, Pascual A, Pachón J and Conejo MC. Efficacy of Colistin and Its Combination with Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. Front. Microbiol 2018. 9:912. Abstract

Copmans D, Rateb M, Tabudravu JN, Pérez-Bonilla M, Dirkx N,  Vallorani R, Diaz C, Pérez del Palacio J, Smith AJ, Ebel R, Reyes F, Jaspars M, de Witte PAM. Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A, ACS Chem. Neurosci. 2018 DOI10.1021/acschemneuro.8b00060. Abstract

Ramos MC, Genilloud O, Reyes F, Vicente F. Drug Discovery from Natural Products for Pancreatic Cancer. Pancreatic Cancer Book. Intech, 2018. DOI: 10.5772/intechopen.76399 Abstract

Sánchez M, González I, Díaz C, Martínez G and Genilloud O. Comparative Genomics and Biosynthetic Potential Analysis of Two Lichen-Isolated Amycolatopsis Strains. Front. Microbiol. 2018, 9:369. doi: 10.3389/fmicb.2018.00369. Abstract

Lacret R, Oves-Costales D, Pérez-Victoria I, de la Cruz M, Díaz C, Vicente F, Genilloud O, Reyes F. MDN-0171, a new medermycin analogue from Streptomyces albolongus CA-186053. Nat. Prod. Res., 2018, DOI:10.1080/14786419.2018.1434636. Abstract

Lauritano C, Martín J, de la Cruz M, Reyes F, Romano G, Ianora A. First identification of marine diatoms with anti-tuberculosis activity. Sci. Rep., 2018, 8:2284. Abstract

Sánchez L, Ladrón de Guevara D, Mañas MC, Alén F, Moreno RD, Díaz C, Perez del Palacio J, García M, Pedraza C, Pavón FJ, Rodríguez de Fonseca F, Santín LJ, Serrano A, Castilla E, Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology (2018), doi: 10.1016/j.neuropharm.2018.01.033. Abstract

Pérez-Bonilla M, Oves-Costales D, de la Cruz M, Kokkini M, Martín J, Vicente F, Genilloud O and Reyes F. Phocoenamicins B and C, New Antibacterial Spirotetronates Isolated from a Marine Micromonospora sp. Mar. Drugs 2018, 16(3), 95; doi:10.3390/md16030095. Abstract

Castillo F, Mackenzie TA, Cautain B. Immunofluorescence analysis by confocal microscopy for detecting endogenous FOXO. Methods in Molecular Biology, DOI 10.1007/978-1.

Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA. Searching for glycosylated natural products in actinomycetes and identification of novel macrolactams and angucyclines. Front. Microbiol., 2018, 9:39. Abstract

2017

Firsova D, Calabro K, Lasserre P, Reyes F, Thomas OP. Isoguanosine Derivatives from the Northeastern Atlantic Sponge Clathria (Microcionastrepsitoxa. Tetrahedron Lett., 2017, 58:4652-4654. Abstract

Genilloud O. Actinomycetes: still a source of novel antibiotics. Nat. Prod. Rep., 2017,34, 1203-1232, 10.1039/C7NP00026J. Abstract

Genilloud O, Industrial Culture Collections: Gateways from Microbial Diversity to Applications  in Microbial Resources: From Functional Existence in Nature to Applications, Ed J. Wink, 2017, Academic Press 237-256.

Ilic J, Cosic J, Vrandecic K, Dugalic K, Pranjic A, Martin J. Influence of endophytic fungi isolated from symptomless weeds on cherry plants. Mycosphere 2017: 8, 18-30. Full article

Peláez F, de Pedro N, Tormo JR. Chapter 9 of the book: Natural Inhibitors of Mitochondrial Respiratory Chain: Therapeutic and Toxicological Implications, in Natural Products Targeting Clinically Relevant Enzymes (eds P. B. Andrade, P. Valentão and D. M. Pereira), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2017, Germany. doi: 10.1002/9783527805921

Braña AF, Sarmiento-Vizcaíno A, Osset M, Pérez-Victoria I, Martín J, de Pedro N, de la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G.  Lobophorin K, a new natural product with cytotoxic activity produced by Streptomyces sp. M-207 associated with the deep-sea coral Lophelia pertusa. Mar. Drugs, 2017, 15:144. Abstract

Calabro K, Kalahroodi EL, Rodrigues D, Díaz C, Cruz M, Cautain B, Laville R, Reyes F, Pérez T, Soussi B, Thomas OP. Poecillastrosides, Steroidal Saponins from the Mediterranean Deep-Sea Sponge Poecillastra compressa (Bowerbank, 1866). Mar Drugs, Jun 15:199, doi: 10.3390/md15070199. Abstract

Pascual J, García-López M, González I, Genilloud O. Luteolibacter gellanilyticus sp. nov., a gellan-gum-degrading bacterium of the phylum Verrucomicrobia isolated from miniaturized diffusion chambers. International Journal of Systematic and Evolutionary Microbiology, Sept. 67(10), DOI:10.1099/ijsem.0.002227. Abstract

Martínez G, González-Menéndez V, Martín J, Reyes F, Genilloud O, Tormo JR. MASS Studio: A Novel Software Utility to Simplify LC-MS Analyses of Large Sets of Samples for Metabolomics. In: Rojas I., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2017. Lecture Notes in Computer Science, vol 10208. Springer, Cham. Abstract

Bertoni-Mann M, Sánchez-Hidalgo M, González-Menéndez V, Genilloud O. Correction for Bertoni-Mann et al., “Draft Genome Sequence of Phytopathogenic Fungus Fusarium proliferatum CF-295141, Isolated from Pinus sylvestris ”. Genome Announcements 2017, 5(43):e01116-17., DOI:10.1128/genomeA.01116-17. Abstract

Almeida C, Bills G, González-Menéndez V, Martin J, Tormo JR, Genilloud O. Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04. Fermentation 2017, 3(3):45., DOI:10.3390/fermentation3030045. Full paper

Boulaiz H, Ramos MC, Griñán-Lisón C, García-Rubiño ME, Vicente F, Marchal JA, What’s new in the diagnosis of pancreatic cancer: a patent review (2011-present), Expert Opinion. Expert Opin Ther Pat. 2017, Sept 10: 1-16. Full paper

Gonzalez-Menendez V, Martin J, Siles JA, Gonzalez-Tejero MR, Reyes F, Platas G, Tormo JR, Genilloud O. Biodiversity and chemotaxonomy of Preussia isolates from the Iberian PeninsulaMycol Progress 2017, Vol.16, 7:713 – 728. Full paper

Ramos MC, Boulaiz H, Griñan-Lison C, Marchal JA, Vicente F. What's new in treatment of pancreatic cancer: a patent review (2010-2017). Expert Opin Ther Pat. 2017, Jul 12:1-16, Full paper

Serrano R, González V, Rodríguez L, Martín J, Tormo JR, Genilloud O. Co-culturing of Fungal Strains Against Botrytis cinerea as a Model for the Induction of Chemical Diversity and Therapeutic Agents. Front. Microbiol., 2017, 649, Full paper

Pérez-del Palacio J, Díaz  C, Vergara N, Algieri F, Rodríguez-Nogales A, de Pedro N, Rodríguez-Cabezas ME, Genilloud O, Gálvez J, Vicente F. Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. Front. Pharmacol, 2017, Full paper

Sonnenschein EC, Stierhof M, Goralczyk S, Vabre FM, Pellissier L, Hanssen KE, de la Cruz M, Díaz C, de Witte P, Copmans D, Andersen JH, Hansen E, Kristoffersen V, Tormo JR, Ebel R, Milne BF, Deng H, Gram L, Jaspars M, Tabudravu JN. Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron, 2017, Chemical Engineering Journal, 2017, 320: 151-159. Abstract

Vela-Soria F, Gallardo Torres ME, Ballesteros O, Diaz C, Perez J, Navalón A, Fernandez MF, Olea N. Assessment of parabens and ultraviolet filters in human placenta tissue by ultrasound-assisted extraction and ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Cromatography A, 2017, 1487: 153-161. Abstract

Borges-Argáez R, Cáceres-Farfán M, De Pedro N, Cautain B, Pérez del Palacio P, Vicente F, Genilloud O, Melguizo A, Díaz C, Reyes F, El Aouad N, Sansores-Peraza P. Cytotoxic studies and in vitro effects oftrans -3,4,4’,5-Tetramethoxystilbene, a bioactive compound isolated from Lonchocarpus punctatus Kunth. Polibotanica, 2017, 43: 165-175. Full paper

Pérez-Bonilla M, González-Menéndez V, Pérez-Victoria I, De Pedro N, Martín J, Molero-Mesa J, Casares-Porcel M, González-Tejero MJ, Vicente F, Genilloud O, Tormo JR, Reyes F. Hormonemate Derivatives from the Endophytic Fungus Dothiora sp. J. Nat. Prod., 2017, DOI: 10.1021/acs.jnatprod.6b00680. Full paper

Crespo G, González-Menéndez V, de la Cruz M, Martín J, Cautain B, Sánchez P, Pérez-Victoria I, Vicente F, Genilloud O, Reyes F. Antifungal long-chain alkenyl sulphates isolated from culture broths of the fungus Chaetopsina spPlanta Med., 2017, 05: 366-491. Abstract

Braña AF, Sarmiento-Vizcaíno A, Pérez-Victoria I, Otero L, Fernández J, Palacios JJ, Martín J, De la Cruz M, Díaz C, Vicente F, Reyes F, García LA, Blanco G. Branimycins B and C, Antibiotics Produced by the abyssal Actinobacterium Pseudonocardia carboxydivorans M-227J. Nat. Prod., 2017, 80: 569-573. Abstract

De la Cruz M, González I, Parish C, Onishi R, Tormo JR, Martín J, Peláez F, Zink D, El Aouad N, Reyes F, Genilloud O, Vicente F. Production of Ramoplanin and Ramoplanin Analogs by Actinomycetes. Front. Microbiol., 2017, 8:343. Fullpaper

Paytubi S, De la Cruz M, Tormo JR, Martín J, González I, González-Menéndez V, Genilloud O, Reyes F, Vicente F, Madrid C, Balsalobre C. Microbial Natural Products High-Throughput Screening Platform for the Discovery of Molecules with Antibiofilm Properties Against Salmonella. Front. Microbiol., 2017, 8: 326. Fullpaper

González A, Gálvez N, Martín J, Reyes F, Pérez-Victoria I, Dominguez-Vera JM. Identification of the key excreted molecule by Lactobacillus fermentum related to host iron absorption. Food Chem., 2017, 228: 374-380. Abstract

2016