MEDINA Invited Seminar Series – Dr. Paul Jensen
Granada, 6 de mayo, 2026.
Fundación MEDINA co-organiza el próximo seminario de la serie EUREMAP Seminar Series, el próximo 27 de mayo a las 16:00 (CEST) en modalidad online. Esta serie de seminarios tiene como objetivo fomentar el intercambio de conocimientos y el debate en torno a las últimas investigaciones en materia de las plataformas de descubrimiento de productos naturales marinos, su aplicación en biotecnología y en campos científicos relacionados.
El seminario será impartido por el Dr. Paul Jensen, del Scripps Institution of Oceanography, University of California San Diego con una charla titulada “Changing paradigms in Natural Product discovery”.
Para asistir al seminario será necesario el registro previo mediante el siguiente link
Abstract
Marine microbes have proven to be a prolific source of novel natural products. Yet the compounds discovered to date largely originate from the relatively few taxa that can be obtained in culture. This suggests that much of the ocean metabolome has yet to be accessed, which is supported by metagenomic analyses that reveal extensive, unrealized biosynthetic potential across marine microbiomes. Exploiting advances in environmental metabolomics, we developed the Small Molecule In situ Resin Capture (SMIRC) technique to capture natural products directly from the environments in which they are produced. SMIRC represent a molecule first approach that bypasses the need for microbial cultivation. Instead, it relies on nature to provide the conditions needed for growth and natural product biosynthesis. SMIRC metabolomes are distinct across biomes, suggesting significant opportunities for discovery. Extract yields have been sufficient for isolation and NMR-based characterization, yielding an extraordinary wealth of chemical diversity including new carbon skeletons with structural features not previously observed among natural products. SMIRC provides a unique approach to access the biosynthetic potential of marine microbes without cultivation or the need to understand the conditions needed to induce biosynthesis.